|
Trihydroxyflavone (6,7,4'-THF)
{{chemistry index ...
Trihydroxyflavone may refer to: * Apigenin (5,7,4'-trihydroxyflavone) * Baicalein (5,6,7-trihydroxyflavone) * Norwogonin (5,7,8-Trihydroxyflavone) * Galangin (3,5,7-trihydroxyflavone) * 7,8,3'-Trihydroxyflavone (7,8,3'-THF) * 6,7,4'-Trihydroxyflavone 6,7,4′-Trihydroxyflavone (6,7,4'-THF) is a flavone, a naturally occurring flavonoid-like chemical compound which is found in heartwood of ''Dalbergia odorifera ''Dalbergia odorifera'', fragrant rosewood or Chinese rosewood (), is a specie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7,8,3'-Trihydroxyflavone
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from tropoflavin (7,8-DHF). Relative to tropoflavin, 7,8,3'-THF is 2–3-fold more potent ''in vitro'' as a TrkB agonist. 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than tropoflavin ''in vitro'', indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity. 7,8,3'-THF has been tested ''in vivo'' and was found to produce TrkB-dependent neuroprotective Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ... effects in mice similarly to tropoflavin. See also * Tropomyosin receptor kinase B § Agonists References Flavones Neuroprotective agents TrkB agonists {{nervous-sys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apigenin
Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool. Sources in nature Apigenin is found in many fruits and vegetables, but parsley, celery, celeriac, and chamomile tea are the most common sources. Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids. Dried parsley can contain about 45 mg apigenin/gram of the herb, and dried chamomile flower about 3-5 mg/gram. The apigenin content of fresh parsley is reportedly 215.5 mg/100 grams, which is much higher than the next highest food source, green celery hearts providing 19.1 mg/100 grams. Biosynthesis Apigenin is biosynthetically derived from the general phenylpropanoid pathway and the flavone synthesis pathway. The phenylpropanoid pathway starts from the aromatic a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norwogonin
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in ''Scutellaria baicalensis'' (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin Tropoflavin, also known as 7,8-dihydroxyflavone, is a naturally occurring flavone found in '' Godmania aesculifolia'', '' Tridax procumbens'', and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of ... (7,8-DHF). See also * Tropomyosin receptor kinase B § Agonists References Flavones TrkB agonists {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galangin
Galangin is a flavonol, a type of flavonoid. Occurrence Galangin is found in high concentrations in plants like ''Alpinia officinarum'' (lesser galangal) and ''Helichrysum aureonitens''. It is also found in the rhizome of ''Alpinia galanga'' and in propolis. Biological activities Galangin has been shown to have ''in vitro'' antibacterial and antiviral activity. It also inhibits the growth of breast tumor cells ''in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...''. References External links Galangin on Chemblink.com {{flavonol Flavonols Resorcinols Steroid sulfotransferase inhibitors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flavon Num
Flavon is a ''frazione'' of the ''comune'' (municipality) of Contà in Trentino in the northern Italian region Trentino-Alto Adige/Südtirol, located about north of Trento Trento ( or ; Ladin and lmo, Trent; german: Trient ; cim, Tria; , ), also anglicized as Trent, is a city on the Adige River in Trentino-Alto Adige/Südtirol in Italy. It is the capital of the autonomous province of Trento. In the 16th centu .... It was an independent commune until 1 January 2016. References {{Authority control Frazioni of Trentino-Alto Adige/Südtirol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baicalein
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of ''Scutellaria baicalensis'' and '' Scutellaria lateriflora''. It is also reported in '' Oroxylum indicum'' (Indian trumpetflower) and ''Thyme''. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, which is a Chinese classic herbal formula, and listed in Japan as Kampo medicine. As a Chinese herbal supplement, it is believed to enhance liver health. Baicalein, along with its analogue baicalin, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. It displays subtype selectivity for α2 and α3 subunit-containing GABAA receptors. In accordance, baicalein shows anxiolytic effects in mice without incidence of sedation or myorelaxation. It is thought that baicalein, along with other flavonoids, may underlie the anxiolytic effects of ''S. baicalensis'' and ''S. late ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
