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Tomáš Cihlář
Tomáš Cihlář (born 1967) is a Czech biochemist known for his role in the development of remdesivir. A specialist in virology, Cihlář holds the positions of Senior Director, Biology, and Vice-President at American pharmaceutical company Gilead Sciences. As a student, Cihlář assisted fellow biochemist Antonín Holý in developing Viread, the primary drug used to fight HIV infection. Education Cihlář graduated from the University of Chemistry and Technology, Prague, majoring in fermentation chemistry and bioengineering under the tutelage of Jan Páca and Vladimír Jirků. He completed his postgraduate studies at the Institute of Organic Chemistry and Biochemistry of the ASCR under Ivan Rosenberg and Ivan Votruba. In 1994 he obtained the title of Candidate of Sciences and was engaged in the research of antiviral agents under the tutelage of Antonín Holý. That same year, he traveled to the United States for a postdoctoral fellowship with Gilead Sciences, where as researche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plzeň
Plzeň (; German and English: Pilsen, in German ) is a city in the Czech Republic. About west of Prague in western Bohemia, it is the Statutory city (Czech Republic), fourth most populous city in the Czech Republic with about 169,000 inhabitants. The city is known worldwide for Pilsner beer, created by Bavarian brewer Josef Groll in the city in 1842. Administrative division Plzeň is divided into ten boroughs, which are further divided into 25 administrative parts (in brackets): *Plzeň 1-Bolevec (Bolevec and Severní Předměstí) *Plzeň 2-Slovany (Božkov, Černice (partly), Doudlevce (partly), Hradiště, Koterov, Lobzy (partly) and Východní Předměstí (partly)) *Plzeň 3-Bory (Doudlevce (partly), Jižní Předměstí, Litice (partly), Nová Hospoda, Radobyčice, Skvrňany, Valcha, Vnitřní Město and Východní Předměstí (partly)) *Plzeň 4-Doubravka (Bukovec, Červený Hrádek, Doubravka, Lobzy (partly), Újezd and Východní Předměstí (partly)) *Plzeň 5-K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MERS
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by ''Middle East respiratory syndrome–related coronavirus'' (MERS-CoV). Symptoms may range from none, to mild, to severe. Typical symptoms include fever, cough, diarrhea, and shortness of breath. The disease is typically more severe in those with other health problems. The first case was identified in June 2012 by Egyptian physician Ali Mohamed Zaki at the Dr. Soliman Fakeeh Hospital in Jeddah, Saudi Arabia, and most cases have occurred in the Arabian Peninsula. Over 2,500 cases have been reported as of January 2021, including 45 cases in the year 2020. About 35% of those who are diagnosed with the disease die from it. Larger outbreaks have occurred in South Korea in 2015 and in Saudi Arabia in 2018. MERS-CoV is a coronavirus believed to be originally from bats. However, humans are typically infected from camels, either during direct contact or indirectly. Spread between humans typically r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronavirus Disease 2019
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickly spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 are variable but often include fever, cough, headache, fatigue, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people are at a higher risk of developing seve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The National Interest
''The National Interest'' (''TNI'') is an American bimonthly international relations magazine edited by American journalist Jacob Heilbrunn and published by the Center for the National Interest, a public policy think tank based in Washington, D.C., that was established by former U.S. President Richard Nixon in 1994 as the Nixon Center for Peace and Freedom. The magazine is associated with the realist school of international studies. History Founded in 1985 by American columnist and neoconservatism advocate Irving Kristol, the magazine was until 2001 edited by Australian academic Owen Harries. In 2001, The National Interest was acquired by The Center for the National Interest, a public policy think tank based in Washington, D.C., that was established by former U.S. President Richard Nixon on January 20, 1994, as the Nixon Center for Peace and Freedom. In 2005, ten editors of ''The National Interest'' resigned due to different viewpoints regarding the magazine's acquisition ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mladá Fronta DNES
''Mladá fronta Dnes'' (''Young Front Today''), also known as ''MF DNES'' or simply ''Dnes'' (''Today''), is a daily newspaper in the Czech Republic.The Czech media landscape - print media Its name could be translated into English as ''Youth Front Today''. As of 2016, it is the second largest Czech newspaper, after the Czech tabloid ''''. History and profile [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Justia
Justia is an American website specializing in legal information retrieval. It was founded in 2003 by Tim Stanley, formerly of FindLaw, and is one of the largest online databases of legal cases. The company is headquartered in Mountain View, California. The website offers free case law, codes, opinion summaries, and other basic legal texts, with paid services for its attorney directory and webhosting. In 2007, ''The New York Times'' reported that Justia was spending around "$10,000 a month" in order "to copy documents" from the United States Supreme Court and publish them online, to be made available without the public paying fees. Law library research guides often refer to Justia. Duke Law School Duke University School of Law (Duke Law School or Duke Law) is the law school of Duke University, a private research university in Durham, North Carolina. One of Duke's 10 schools and colleges, the School of Law is a constituent academic unit th ...'s law library's research guide n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse-transcriptase Inhibitor
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs Enzyme inhibition, inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Mechanism of action When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying. A similar process occurs with other types of viruses. The hepatitis B virus, for example, carries its genetic material in the form of DNA, and employs an RNA-dependent DNA polymerase to replicate. Some of the same compou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Society For Antiviral Research
The International Society for Antiviral Research (ISAR) is a scientific society that focuses on the discovery and clinical application of antiviral agents. It was founded in 1987 to encourage the exchange of information and collaborative research on the development of antiviral, biological and chemical agents. ISAR sponsors the International Conference on Antiviral Research (ICAR), held yearly since 1988 when the second ICAR occurred in Williamsburg, Virginia. ISAR also provides scientific information through peer-reviewed scientific journals and administers several international awards. , the president of the society was Johan Neyts and the president-elect was Kara Carter. Johan Neyts was succeeded as president by Kara Carter, and the president-elect for 2020-2022 became Katherine Seley-Radtke. Founding The foundation for the International Society for Antiviral Research (ISAR) was laid at meetings held in Rotterdam, Netherlands (April 30 – May 3, 1985) and in Il Ciocco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Prusoff
William Herman Prusoff (June 25, 1920 – April 3, 2011) was a pharmacologist who was an early innovator in antiviral drugs, developing idoxuridine, the first antiviral agent approved by the FDA, in the 1950s, and co-developing (with Tai-shun Lin) stavudine, one of the earliest AIDS drugs, in the mid-1980s. Scientific career William Prusoff attended the University of Miami. After receiving his undergraduate degree in chemistry, he obtained his PhD from Columbia University and later completed his postdoctoral training in the laboratory of professor Arnold Welch at Case Western Reserve University. After Welch was recruited by Yale to head the Medical School's pharmacology department, Prusoff was invited to join the same department as an assistant professor and was subsequently promoted to the rank of professor. This relationship at Yale would span over the next 58 years, with William Prusoff becoming one of Yale's most well respected scientists and teachers. Prusoff spent most ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. Endosomes can be classified as early, sorting, or late depending on their stage post internalization. Endosomes represent a major sorting compartment of the endomembrane system in cells. Function Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome. For example, low-density lipoprotein (LDL) is taken into the cell by binding to the LDL receptor at the cell surface. Upon reaching early endosomes, the LDL dissociates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLR7
Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the ''TLR7'' gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA. Function The TLR family plays an important role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from ''Drosophila'' to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on the human X chromosome. TLR7 recognizes single-stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive Types of agonists can be activated by either endogenous agonists (such as |
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