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Thomas McPherson Brown
Thomas McPherson Brown (1906–1989) was a rheumatologist who held unorthodox views about the basis of rheumatoid arthritis (RA), and believed it could be cured with antibiotics. Brown graduated from Swarthmore College then attended Johns Hopkins Medical School. He did his medical residency at the hospital associated with the Rockefeller Institute.At Rockefeller he did research on synovial fluid from people with RA and in 1937 found ''Mycoplasma'' in the fluid from some patients, leading him to believe that RA might be an infectious disease. His work was interrupted by service in World War II; after the war he obtained a position at George Washington University and began to experimentally treat some people with RA with antibiotics, which at the time were a new class of drugs. Some of the people he treated were members of Congress or ambassadors, and some of them responded positively. He presented his work at a conference in 1949; at the same conference, the new drug cortisone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body, including skin, eyes, lungs, heart, nerves and blood. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months. While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swarthmore College
Swarthmore College ( , ) is a Private college, private Liberal arts colleges in the United States, liberal arts college in Swarthmore, Pennsylvania. Founded in 1864, with its first classes held in 1869, Swarthmore is one of the earliest coeducational colleges in the United States. It was established as a college "under the care of Quakers, Friends, [and] at which an education may be obtained equal to that of the best institutions of learning in our country." By 1906, Swarthmore had dropped its religious affiliation and officially became non-sectarian. Swarthmore is a member of the Tri-College Consortium, a cooperative academic arrangement with Bryn Mawr College, Bryn Mawr and Haverford College. Swarthmore also is affiliated with the University of Pennsylvania through the Quaker Consortium, which allows for students to cross-register for classes at all four institutions. Swarthmore offers over 600 courses per year in more than 40 areas of study, including an ABET-accredited engin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins Medical School
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospital and Johns Hopkins Children's Center, established in 1889. It has consistently ranked among the top medical schools in the United States in terms of the number/amount of research grants/funding awarded by the National Institutes of Health, among other measures. History The founding physicians (the "Four Doctors") of the Johns Hopkins School of Medicine included pathologist William Henry Welch (1850–1934), the first dean of the school and a mentor to generations of research scientists; a Canadian, internist Sir William Osler (1849–1919), regarded as the ''Father of Modern Medicine'', having been perhaps the most influential physician of the late 19th and early 20th centuries as author of '' The Principles and Practice of Medicine'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synovial Fluid
Synovial fluid, also called synovia, elp 1/sup> is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With its egg white–like consistency, the principal role of synovial fluid is to reduce friction between the articular cartilage of synovial joints during movement. Synovial fluid is a small component of the transcellular fluid component of extracellular fluid. Structure The inner membrane of synovial joints is called the synovial membrane and secretes synovial fluid into the joint cavity. Synovial fluid is an ultrafiltrate from plasma, and contains proteins derived from the blood plasma and proteins that are produced by cells within the joint tissues. The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma. This fluid forms a thin layer (roughly 50 μm) at the surface of c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycoplasma
''Mycoplasma'' is a genus of bacteria that, like the other members of the class ''Mollicutes'', lack a cell wall around their cell membranes. Peptidoglycan (murein) is absent. This characteristic makes them naturally resistant to antibiotics that target cell wall synthesis (like the beta-lactam antibiotics). They can be parasitic or saprotrophic. Several species are pathogenic in humans, including '' M. pneumoniae'', which is an important cause of "walking" pneumonia and other respiratory disorders, and '' M. genitalium'', which is believed to be involved in pelvic inflammatory diseases. ''Mycoplasma'' species (like the other species of the class ''Mollicutes'') are among the smallest organisms yet discovered, can survive without oxygen, and come in various shapes. For example, ''M. genitalium'' is flask-shaped (about 300 x 600 nm), while ''M. pneumoniae'' is more elongated (about 100 x 1000 nm), many ''Mycoplasma'' species are coccoid. Hundreds of ''Mycoplasma'' species i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Washington University
, mottoeng = "God is Our Trust" , established = , type = Private federally chartered research university , academic_affiliations = , endowment = $2.8 billion (2022) , president = Mark S. Wrighton , provost = Christopher Bracey , students = 27,159 (2016) , undergrad = 11,244 (2016) , postgrad = 15,486 (2016) , other = 429 (2016) , faculty = 2,663 , city = Washington, D.C. , country = U.S. , campus = Urban, , former_names = Columbian College (1821–1873)Columbian University (1873–1904) , sports_nickname = Colonials , mascot = George , colors = Buff & blue , sporting_affiliations = NCAA Division I – A-10 , website = , free_label = Newspaper , ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cortisone
Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enzyme corticosteroid 11-beta-dehydrogenase isozyme 2 into the inactive metabolite cortisone, particularly in the kidneys. Cortisone is converted back to the active steroid cortisol by the action of the enzyme 11β-Hydroxysteroid dehydrogenase type 1, particularly in the liver. The term "cortisone" is frequently misused to mean either any corticosteroid or hydrocortisone, which is actually another name for cortisol. Many who speak of receiving a "cortisone shot" or taking "cortisone" are actually receiving hydrocortisone or one of many other, much more potent synthetic corticosteroids; it is unlikely that the drug administered is actually cortisone. Cortisone can be administered as a prodrug, meaning it has to be converted by the body (speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1906 Births
Events January–February * January 12 – Persian Constitutional Revolution: A nationalistic coalition of merchants, religious leaders and intellectuals in Persia forces the shah Mozaffar ad-Din Shah Qajar to grant a constitution, and establish a national assembly, the Majlis. * January 16–April 7 – The Algeciras Conference convenes, to resolve the First Moroccan Crisis between France and Germany. * January 22 – The strikes a reef off Vancouver Island, Canada, killing over 100 (officially 136) in the ensuing disaster. * January 31 – The Ecuador–Colombia earthquake (8.8 on the Moment magnitude scale), and associated tsunami, cause at least 500 deaths. * February 7 – is launched, sparking a naval race between Britain and Germany. * February 11 ** Pope Pius X publishes the encyclical ''Vehementer Nos'', denouncing the 1905 French law on the Separation of the Churches and the State. ** Two British members of a poll tax collecting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1989 Deaths
File:1989 Events Collage.png, From left, clockwise: The Cypress Street Viaduct, Cypress structure collapses as a result of the 1989 Loma Prieta earthquake, killing motorists below; The proposal document for the World Wide Web is submitted; The Exxon Valdez oil tanker runs aground in Prince William Sound, Alaska, causing a large Exxon Valdez oil spill, oil spill; The Fall of the Berlin Wall begins the downfall of Communism in Eastern Europe, and heralds German reunification; The United States United States invasion of Panama, invades Panama to depose Manuel Noriega; The Singing Revolution led to the independence of the Baltic states of Estonia, Latvia, and Lithuania from the Soviet Union; The stands of Hillsborough Stadium in Sheffield, Yorkshire, where the Hillsborough disaster occurred; 1989 Tiananmen Square protests and massacre, Students demonstrate in Tiananmen Square, Beijing; many are killed by forces of the Chinese Communist Party., 300x300px, thumb rect 0 0 200 200 1989 Loma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Rheumatologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * Ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
