The Hot Zone
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The Hot Zone
''The Hot Zone: A Terrifying True Story'' is a best-selling 1994 nonfiction thriller by Richard Preston about the origins and incidents involving viral hemorrhagic fevers, particularly ebolaviruses and marburgviruses. The basis of the book was Preston's 1992 '' New Yorker'' article "Crisis in the Hot Zone". The filoviruses—including Ebola virus, Sudan virus, Marburg virus, and Ravn virus—are Biosafety Level 4 agents, extremely dangerous to humans because they are very infectious, have a high fatality rate, and most have no known prophylactic measures, treatments, or cures. Along with describing the history of the devastation caused by two of these Central African diseases, Ebola virus disease and Marburg virus disease, Preston described a 1989 incident in which a relative of Ebola virus, Reston virus, was discovered at a primate quarantine facility in Reston, Virginia, less than 15 miles (24 km) away from Washington, D.C. Synopsis The book is in four secti ...
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Reston, Virginia
Reston is a census-designated place in Fairfax County, Virginia and a principal city of the Washington metropolitan area. As of the 2020 U.S. Census, Reston's population was 63,226. Founded in 1964, Reston was influenced by the Garden City movement that emphasized planned, self-contained communities that intermingled green space, residential neighborhoods, and commercial development. The intent of Reston's founder, Robert E. Simon, was to build a town that would revolutionize post–World War II concepts of land use and residential/corporate development in suburban America. In 2018, Reston was ranked as the Best Place to Live in Virginia by ''Money'' magazine for its expanses of parks, lakes, golf courses, and bridle paths as well as the numerous shopping and dining opportunities in Reston Town Center. History In the early days of Colonial America, the land on which Reston sits was part of the Northern Neck Proprietary, a vast grant by King Charles II to Lord Thomas Fairfa ...
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Richard Preston
Richard Preston (born August 5, 1954) is a writer for ''The New Yorker'' and bestselling author who has written books about infectious disease, bioterrorism, redwoods and other subjects, as well as fiction. Biography Preston was born in Cambridge, Massachusetts. He graduated Wellesley High School in Massachusetts in 1972 and attended Pomona College in Claremont, California. He earned a Ph.D. in English from Princeton University in 1983. His 1992 ''New Yorker'' article "Crisis in the Hot Zone" was expanded into his breakout book, ''The Hot Zone'' (1994). It is classified as a "non-fiction thriller" about ebolaviruses. He learned of ebola through such contacts as U.S. Army researchers Drs. C.J. Peters and Nancy Jaax. His fascination began during a visit to Africa where he was an eyewitness to epidemics. The book served as the (very loose) basis of the Hollywood movie ''Outbreak'' (1995) about military machinations surrounding a fictional "Motaba virus". Preston's novel ''The ...
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Central Africa
Central Africa is a subregion of the African continent comprising various countries according to different definitions. Angola, Burundi, the Central African Republic, Chad, the Democratic Republic of the Congo, the Republic of the Congo, Equatorial Guinea, Gabon, Rwanda, and São Tomé and Príncipe are members of the Economic Community of Central African States (ECCAS). Six of those states (the Central African Republic, Chad, the Republic of the Congo, Equatorial Guinea, and Gabon) are also members of the Economic and Monetary Community of Central Africa (CEMAC) and share a common currency, the Central African CFA franc. The African Development Bank defines Central Africa as the Central African Republic, Chad, the Democratic Republic of the Congo, the Republic of the Congo, Equatorial Guinea, and Gabon. Middle Africa is an analogous term used by the United Nations in its geoscheme for Africa. It includes the same countries as the African Development Bank's definiti ...
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United States Army Medical Research Institute Of Infectious Diseases
The United States Army Medical Research Institute of Infectious Diseases (USAMRIID; pronounced: you-SAM-rid) is the U.S Army's main institution and facility for defensive research into countermeasures against biological warfare. It is located on Fort Detrick, Maryland, near Washington, D.C. and is a subordinate lab of the U.S. Army Medical Research and Development Command (USAMRDC), headquartered on the same installation. USAMRIID is the only U.S. Department of Defense (DoD) laboratory equipped to study highly hazardous viruses at Biosafety Level 4 within positive pressure personnel suits. USAMRIID employs both military and civilian scientists as well as highly specialized support personnel, totaling around 800 people. In the 1950s and '60s, USAMRIID and its predecessor unit pioneered unique, state-of-the-art biocontainment facilities which it continues to maintain and upgrade. Investigators at its facilities frequently collaborate with the Centers for Disease Control an ...
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Peter Jahrling
Peter B. Jahrling is chief of the Emerging Viral Pathogens Section of the National Institute of Allergy and Infectious Diseases. Jahrling received his PhD in medical microbiology from Cornell Medical College. He joined the military as an officer at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), and remained employed as a civilian after his service. Since 2005, Jahrling has been the chief scientist of the NIAID Integrated Research Facility in Frederick, Maryland, and chief of the Emerging Viral Pathogens Section. His research focuses on the development of animal models for viruses infecting humans, strategies for vaccination and treatment of serious viral pathogens, and characterization of newly discovered viruses. He oversees BSL-4 labs at Fort Detrick. ''The Hot Zone'' mentions Jahrling's early research in Ebola virus. He is portrayed in the first season of ''The Hot Zone'' television series by Topher Grace. Awards * 2003 Elected fellow of the Am ...
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Centers For Disease Control
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgia. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It especially focuses its attention on infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities designed to improve the health of United States citizens. The CDC also conducts research and provides information on non-infectious diseases, such as obesity and diabetes, and is a founding member of the International Association of National Public Health Institutes.
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Mount Elgon
Mount Elgon is an extinct shield volcano on the border of Uganda and Kenya, north of Kisumu and west of Kitale. The mountain's highest point, named "Wagagai", is located entirely within Uganda."Mount Elgon, Uganda" Peakbagger.com.
Retrieved 11 January 2012
Although there is no verifiable evidence of its earliest volcanic activity, geologists estimate that Mount Elgon is at least 24 million years old, making it the oldest extinct volcano in . The mountain's name originates from its Maasai name, Elgonyi.


Physical features

Mount El ...
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Kitum Cave
Kitum Cave is located in Mount Elgon National Park, Kenya. In the 1980s, two European visitors contracted Marburg virus disease there. It is one of five named “elephant caves” of Mount Elgon where animals, including elephants, “mine” the rock for its sodium-rich salts. Description Kitum Cave is a non-solutional cave developed in pyroclastic (volcanic) rocks (not, as some have presumed, a lava tube). It extends about into the side of Mount Elgon near the Kenyan border with Uganda. The walls are rich in salt, and animals such as elephants have gone deep into the cave for centuries in search of salt. The elephants use their tusks to break off pieces of the cave wall that they then chew and swallow, leaving the walls scratched and furrowed; their actions have likely enlarged the cave over time. When the cave was first discovered, it was thought that ancient Egyptians had made the marks on the cave walls as they attempted to mine with picks for precious metals or gemstones. Ot ...
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Pseudonym
A pseudonym (; ) or alias () is a fictitious name that a person or group assumes for a particular purpose, which differs from their original or true name (orthonym). This also differs from a new name that entirely or legally replaces an individual's own. Many pseudonym holders use pseudonyms because they wish to remain Anonymity, anonymous, but anonymity is difficult to achieve and often fraught with legal issues. Scope Pseudonyms include stage names, User (computing), user names, ring names, pen names, aliases, superhero or villain identities and code names, gamer identifications, and regnal names of emperors, popes, and other monarchs. In some cases, it may also include nicknames. Historically, they have sometimes taken the form of anagrams, Graecisms, and Latinisation (literature), Latinisations. Pseudonyms should not be confused with new names that replace old ones and become the individual's full-time name. Pseudonyms are "part-time" names, used only in certain contexts – ...
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AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to ch ...
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Washington, D
Washington commonly refers to: * Washington (state), United States * Washington, D.C., the capital of the United States ** A metonym for the federal government of the United States ** Washington metropolitan area, the metropolitan area centered on Washington, D.C. * George Washington (1732–1799), the first president of the United States Washington may also refer to: Places England * Washington, Tyne and Wear, a town in the City of Sunderland metropolitan borough ** Washington Old Hall, ancestral home of the family of George Washington * Washington, West Sussex, a village and civil parish Greenland * Cape Washington, Greenland * Washington Land Philippines *New Washington, Aklan, a municipality *Washington, a barangay in Catarman, Northern Samar *Washington, a barangay in Escalante, Negros Occidental *Washington, a barangay in San Jacinto, Masbate *Washington, a barangay in Surigao City United States * Washington, Wisconsin (other) * Fort Washington (other) ...
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