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TAVI
Percutaneous aortic valve replacement (PAVR), also known as percutaneous aortic valve implantation (PAVI), transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR), is the replacement of the aortic valve of the heart through the blood vessels (as opposed to valve replacement by open heart surgery, surgical aortic valve replacement, SAVR). The replacement valve is delivered via one of several access methods: transfemoral (in the upper leg), transapical (through the wall of the heart), subclavian (beneath the collar bone), direct aortic (through a minimally invasive surgical incision into the aorta), and transcaval (from a temporary hole in the aorta near the navel through a vein in the upper leg), among others. Severe symptomatic aortic stenosis carries a poor prognosis. At present there is no treatment via medication, making the timing of aortic valve replacement the most important decision to make for these patients. Until recently, surgi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aortic Stenosis
Aortic stenosis (AS or AoS) is the narrowing of the exit of the left ventricle of the heart (where the aorta begins), such that problems result. It may occur at the aortic valve as well as above and below this level. It typically gets worse over time. Symptoms often come on gradually with a decreased ability to exercise often occurring first. If heart failure, loss of consciousness, or heart related chest pain occur due to AS the outcomes are worse. Loss of consciousness typically occurs with standing or exercising. Signs of heart failure include shortness of breath especially when lying down, at night, or with exercise, and swelling of the legs. Thickening of the valve without narrowing is known as aortic sclerosis. Causes include being born with a bicuspid aortic valve, and rheumatic fever; a normal valve may also harden over the decades. A bicuspid aortic valve affects about one to two percent of the population. As of 2014 rheumatic heart disease mostly occurs in the dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aortic Valve Replacement
Aortic valve replacement is a procedure whereby the failing aortic valve of a patient's heart is replaced with an artificial heart valve. The aortic valve may need to be replaced because: * The valve is leaky (aortic insufficiency, also known as aortic regurgitation) * The valve is narrowed and doesn't open fully (aortic stenosis) Current methods for aortic valve replacement include open-heart surgery, termed ''minimally invasive cardiac surgery (MICS)'' or ''surgical aortic valve replacement'' (SAVR) and percutaneous or transcatheter aortic valve replacement (TAVR; also PAVR, PAVI, TAVI). A competent practising cardiologist can evaluate whether a patient could benefit from heart valve repair. History During the late 1940s and early 1950s, the first surgical approaches towards treating aortic valve stenosis had limited success. The first attempts were valvotomies, (i.e. cutting the valve while the heart is pumping). A ball valve prosthesis placed on the descending thoraci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aortic Valve Replacement
Aortic valve replacement is a procedure whereby the failing aortic valve of a patient's heart is replaced with an artificial heart valve. The aortic valve may need to be replaced because: * The valve is leaky (aortic insufficiency, also known as aortic regurgitation) * The valve is narrowed and doesn't open fully (aortic stenosis) Current methods for aortic valve replacement include open-heart surgery, termed ''minimally invasive cardiac surgery (MICS)'' or ''surgical aortic valve replacement'' (SAVR) and percutaneous or transcatheter aortic valve replacement (TAVR; also PAVR, PAVI, TAVI). A competent practising cardiologist can evaluate whether a patient could benefit from heart valve repair. History During the late 1940s and early 1950s, the first surgical approaches towards treating aortic valve stenosis had limited success. The first attempts were valvotomies, (i.e. cutting the valve while the heart is pumping). A ball valve prosthesis placed on the descending thoraci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alain Cribier
Alain Cribier, FACC, FESC (born 1945) is a French interventional cardiologist, who is a Professor of Medicine and Director of Cardiology at the University of Rouen's Charles Nicolle Hospital. Alain Cribier is best known for performing the world's first transcatheter aortic valve implantation in 2002, the first mitral commissurotomy in 1995 and the first balloon aortic valvuloplasty in 1986. Education Cribier obtained his MD medical degree at the University of Paris and completed his early residency training there. Cribier began his cardiology residency at the University of Rouen in 1972 and in 1976 he spent a year in an interventional cardiology fellowship at the Cedars-Sinai Hospital in Los Angeles, California. Career In 1983, Cribier was promoted to a Professor of Medicine and the Director of the Catheterization Lab at the University of Rouen. He developed and performed the world's first balloon aortic valvuloplasty in 1986. He performed the world's first mitral commissurot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interventional Cardiology
Interventional cardiology is a branch of cardiology that deals specifically with the catheter based treatment of structural heart diseases. Andreas Gruentzig is considered the father of interventional cardiology after the development of angioplasty by interventional radiologist Charles Dotter. Many procedures can be performed on the heart by catheterization. This most commonly involves the insertion of a sheath into the femoral artery (but, in practice, any large peripheral artery or vein) and cannulating the heart under X-ray visualization (most commonly fluoroscopy). The radial artery may also be used for cannulation; this approach offers several advantages, including the accessibility of the artery in most patients, the easy control of bleeding even in anticoagulated patients, the enhancement of comfort because patients are capable of sitting up and walking immediately following the procedure, and the near absence of clinically significant sequelae in patients with a normal All ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aortic Valve
The aortic valve is a valve in the heart of humans and most other animals, located between the left ventricle and the aorta. It is one of the four valves of the heart and one of the two semilunar valves, the other being the pulmonary valve. The aortic valve normally has three cusps or leaflets, although in 1–2% of the population it is found to congenitally have two leaflets. The aortic valve is the last structure in the heart the blood travels through before stopping the flow through the systemic circulation. Structure The aortic valve normally has three cusps however there is some discrepancy in their naming. They may be called the left coronary, right coronary and non-coronary cusp. Some sources also advocate they be named as a left, right and posterior cusp. Anatomists have traditionally named them the left posterior (origin of left coronary), anterior (origin of the right coronary) and right posterior. The three cusps, when the valve is closed, contain a sinus called an a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edwards Lifesciences
Edwards Lifesciences is an American medical technology company headquartered in Irvine, California, specializing in artificial heart valves and hemodynamic monitoring. It developed the SAPIEN transcatheter aortic heart valve made of cow tissue within a balloon-expandable, cobalt-chromium frame, deployed via catheter. The company has manufacturing facilities at the Irvine headquarters, as well as in Draper, Utah; Costa Rica; the Dominican Republic; Puerto Rico; and Singapore; and is building a new facility due to be completed in 2021 in Limerick, Ireland. History Edwards was originally founded by engineer Miles “Lowell” Edwards in 1958. Edwards and Dr. Albert Starr, a surgeon at the University of Oregon Medical School, designed, developed, tested and successfully placed in a patient the first Starr-Edwards mitral valve in 1960. As a result of the successful heart surgery, Edwards Laboratories was founded in Santa Ana, California that same year. Edwards was acquired by Baxter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NewYork–Presbyterian
The NewYork-Presbyterian Hospital is a nonprofit academic medical center in New York City affiliated with two Ivy League medical schools, Cornell University and Columbia University. The hospital comprises seven distinct campuses located in the New York metropolitan area. The hospital's two flagship medical centers are Columbia University Irving Medical Center and Weill Cornell Medical Center. , the hospital is ranked as the seventh best hospital in the United States and the second in the New York City metropolitan area by '' U.S. News & World Report''. The hospital has more than 6,500 affiliated physicians, 20,000 employees and 2,600 beds in total. It is one of the largest hospitals in the world. NYPH annually treats about 310,000 patients in its emergency department and delivers about 15,000 babies. History NewYork-Presbyterian Hospital was founded in 1771 as New York Hospital by Edinburgh Medical School graduate Samuel Bard. It received a Royal Charter granted by King Geor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Rouen
The University of Rouen Normandy (''Université de Rouen Normandie'') is a French university, in the Academy of Rouen. History and demographics Located not in Rouen, but in the suburb of Mont-Saint-Aignan (a "township" in the Normandy region), the University of Rouen Normandy opened in 1966 as an off-shoot of the University of Caen. It is a large public university with over 25,000 students enrolled. Ranking According to U.S. News & World Report, University of Rouen Normandy made #835 (in a 3-way tie with Assiut University in Egypt and Universidad de Antioquia in Colombia) on the Best Global Universities list (published October 24, 2017) out of 1,250 universities being judged. University of Rouen Normandy was also compared to 66 other French universities and was ranked #45. These rankings are based on the reputation of the university as well as the extent and quality of the research performed at each location. Achievements *First transcatheter aortic valve implantation in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantitative Research
Quantitative research is a research strategy that focuses on quantifying the collection and analysis of data. It is formed from a deductive approach where emphasis is placed on the testing of theory, shaped by empiricist and positivist philosophies. Associated with the natural, applied, formal, and social sciences this research strategy promotes the objective empirical investigation of observable phenomena to test and understand relationships. This is done through a range of quantifying methods and techniques, reflecting on its broad utilization as a research strategy across differing academic disciplines. The objective of quantitative research is to develop and employ mathematical models, theories, and hypotheses pertaining to phenomena. The process of measurement is central to quantitative research because it provides the fundamental connection between empirical observation and mathematical expression of quantitative relationships. Quantitative data is any data that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticoagulants
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet aggre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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