T Maze Test
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T Maze Test
In behavioral science, a T-maze (or the variant Y-maze) is a simple forked passage used in animal cognition experiments.Olton, D.S. (1979). Mazes, maps, and memory. ''American Psychologist'', 34, 583–596). It is shaped like the letter T (or Y), providing the subject, typically a rodent, with a straightforward choice. T-mazes are used to study how the rodents function with memory and spatial learning through applying various stimuli. Starting in the early 20th century, rodents were used in experiments such as the T-maze. These concepts of T-mazes are used to assess rodent behavior. The different tasks, such as left-right discrimination and forced alternation, are mainly used with rodents to test reference and working memory. Apparatus The T-maze is one of a group of various mazes of differing sizes and many shapes. It is one of the most simple, consisting of just two turns – right or left. The maze is only able to be altered by blocking one of the two paths. The basis ...
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202109 T Maze Test Mouse Placed In One Arm With Food
1 (one, unit, unity) is a number representing a single or the only entity. 1 is also a numerical digit and represents a single unit of counting or measurement. For example, a line segment of ''unit length'' is a line segment of length 1. In conventions of sign where zero is considered neither positive nor negative, 1 is the first and smallest positive integer. It is also sometimes considered the first of the infinite sequence of natural numbers, followed by  2, although by other definitions 1 is the second natural number, following  0. The fundamental mathematical property of 1 is to be a multiplicative identity, meaning that any number multiplied by 1 equals the same number. Most if not all properties of 1 can be deduced from this. In advanced mathematics, a multiplicative identity is often denoted 1, even if it is not a number. 1 is by convention not considered a prime number; this was not universally accepted until the mid-20th century. Additionally, 1 is the s ...
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Behavioral Science
Behavioral sciences explore the cognitive processes within organisms and the behavioral interactions between organisms in the natural world. It involves the systematic analysis and investigation of human and animal behavior through naturalistic observation, controlled scientific experimentation and mathematical modeling. It attempts to accomplish legitimate, objective conclusions through rigorous formulations and observation.Klemke, E. D., Hollinger, R., and Kline, A. D., (1980), Introduction to the book in 'Introductory Readings in the Philosophy of Science': Buffalo, New York, Prometheus Books p 11-12 Examples of behavioral sciences include psychology, psychobiology, anthropology, economics, and cognitive science. Generally, behavioral science primarily has shown how human action often seeks to generalize about human behavior as it relates to society and its impact on society as a whole. Categories Behavioral sciences include two broad categories: neural ''Information science ...
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Animal Cognition
Animal cognition encompasses the mental capacities of non-human animals including insect cognition. The study of animal conditioning and learning used in this field was developed from comparative psychology. It has also been strongly influenced by research in ethology, behavioral ecology, and evolutionary psychology; the alternative name cognitive ethology is sometimes used. Many behaviors associated with the term ''animal intelligence'' are also subsumed within animal cognition. Researchers have examined animal cognition in mammals (especially primates, cetaceans, elephants, dogs, cats, pigs, horses, cattle, raccoons and rodents), birds (including parrots, fowl, corvids and pigeons), reptiles ( lizards, snakes, and turtles), fish and invertebrates (including cephalopods, spiders and insects). Historical background Earliest inferences The mind and behavior of non-human animals has captivated the human imagination for centuries. Many writers, such as Descart ...
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American Psychologist
''American Psychologist'' is a peer-reviewed academic journal published by the American Psychological Association. The journal publishes articles of broad interest to psychologists, including empirical reports and scholarly reviews covering science, practice, education, and policy, and occasionally publishes special issues on relevant topics in the field of psychology. The editor-in-chief is Harris Cooper (Duke University). The journal has implemented the Transparency and Openness Promotion (TOP) Guidelines that provide structure to research planning and reporting and aim to make research more transparent, accessible, and reproducible. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 16.358. See also * ''Developmental Psychology'' *''Journal of Abnormal Psychology'' *''Journal of Experimental Psychology The ''Journal of Experimental Psychology'' was a bimonthly peer-reviewed ...
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Spatial Learning
In cognitive psychology and neuroscience, spatial memory is a form of memory responsible for the recording and recovery of information needed to plan a course to a location and to recall the location of an object or the occurrence of an event. Spatial memory is necessary for orientation in space. Spatial memory can also be divided into egocentric and allocentric spatial memory. A person's spatial memory is required to navigate around a familiar city. A rat's spatial memory is needed to learn the location of food at the end of a maze. In both humans and animals, spatial memories are summarized as a cognitive map. Spatial memory has representations within working, short-term memory and long-term memory. Research indicates that there are specific areas of the brain associated with spatial memory. Many methods are used for measuring spatial memory in children, adults, and animals. Short-term spatial memory Short-term memory (STM) can be described as a system allowing one to tempora ...
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Long-term Potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength. It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength. As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory. LTP was discovered in the rabbit hippocampus by Terje Lømo in 1966 and has remained a popular subject of research since. Many modern LTP studies seek to better understand its basic biology, while others aim to draw a causal link between LTP and behavioral learning. Still, others try to develop methods, pharmacologic or otherwise, of enhanc ...
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Radial Arm Maze
The radial arm maze was designed by Olton and Samuelson in 1976 to measure spatial learning and memory in rats. The original apparatus consists of eight equidistantly spaced arms, each about 4 feet long, and all radiating from a small circular central platform (later versions have used as few as three and as many as 48 arms). At the end of each arm there is a food site, the contents of which are not visible from the central platform. Two types of memory that are assessed during the performance in this task are reference memory and working memory. Reference memory is assessed when the rats only visit the arms of the maze which contains the reward. The failure to do so will result in reference memory error. Working memory is assessed when the rats enter each arm a single time. Re-entry into the arms would result in a working memory error. The design ensures that, after checking for food at the end of each arm, the rat is always forced to return to the central platform before making ...
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Short-term Memory
Short-term memory (or "primary" or "active memory") is the capacity for holding a small amount of information in an active, readily available state for a short interval. For example, short-term memory holds a phone number that has just been recited. The duration of short-term memory (absent rehearsal or active maintenance) is estimated to be on the order of seconds. The commonly cited capacity of 7 items, found in Miller's Law, has been superseded by 4±1 items. In contrast, long-term memory holds information indefinitely. Short-term memory is not the same as working memory, which refers to structures and processes used for temporarily storing and manipulating information. Stores The idea of separate memories for short-term and long-term storage originated in the 19th century. A model of memory developed in the 1960s assumed that all memories are formed in one store and transfer to others store after a small period of time. This model is referred to as the "modal model", most ...
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Hippocampus
The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. The hippocampus is located in the allocortex, with neural projections into the neocortex in humans, as well as primates. The hippocampus, as the medial pallium, is a structure found in all vertebrates. In humans, it contains two main interlocking parts: the hippocampus proper (also called ''Ammon's horn''), and the dentate gyrus. In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of the brain to suffer damage; short-term memory loss and disorientation are included among the early symptoms. Damage to the hippocampus can also result from ...
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Medial Temporal Lobe
The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain. The temporal lobe is involved in processing sensory input into derived meanings for the appropriate retention of visual memory, language comprehension, and emotion association. ''Temporal'' refers to the head's temples. Structure The temporal lobe consists of structures that are vital for declarative or long-term memory. Declarative (denotative) or explicit memory is conscious memory divided into semantic memory (facts) and episodic memory (events). Medial temporal lobe structures that are critical for long-term memory include the hippocampus, along with the surrounding hippocampal region consisting of the perirhinal, parahippocampal, and entorhinal neocortical regions. The hippocampus is critical for memory formation, and the surrounding medial temporal cortex is curre ...
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Barnes Maze
The Barnes maze is a tool used in psychological laboratory experiments to measure spatial learning and memory. The test was first developed by Dr. Carol Barnes in 1979. The test subjects are usually rodents such as mice or lab rats, which either serve as a control or may have some genetic variable or deficiency present in them which will cause them to react to the maze differently. The basic function of Barnes maze is to measure the ability of a mouse to learn and remember the location of a target zone using a configuration of distal visual cues located around the testing area. This noninvasive task is useful for evaluating novel chemical entities for their effects on cognition as well as identifying cognitive deficits in transgenic strains of rodents that model for disease such as Alzheimer's disease. It is also used by neuroscientists to determine whether there is a causative effect after mild traumatic brain injury on learning deficits (acquisition trials) and spatial memory rete ...
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Elevated Plus Maze
The elevated plus maze (EPM) is a test measuring anxiety in laboratory animals that usually uses rodents as a screening test for putative anxiolytic or anxiogenic compounds and as a general research tool in neurobiological anxiety research such as PTSD and TBI. The model is based on the test animal's aversion to open spaces and tendency to be thigmotaxic. In the EPM, this anxiety is expressed by the animal spending more time in the enclosed arms. Method The test uses an elevated, plus-shaped (+) apparatus with two open and two enclosed arms. The behavioral model is based on the general aversion of rodents to open spaces. This aversion leads to thigmotaxis: a preference for remaining in enclosed spaces or close to the edges of a bounded space. In the EPM, this translates into the animals limiting their movement to the enclosed arms. Anxiety reduction is indicated in the plus-maze by an increase in the proportion of time spent in the open arms (time in open arms/total time i ...
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