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TMEM176B
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells. Gene Location TMEM176B is also known as LR8, and MS4B2. The gene is found on the minus end of Chromosome 7, on the long arm at position 7q36.1. The starting position of the gene is at 150,791,287 and goes to 150,801,360. It has 10,074 base pairs and has a total of 11 exons. Gene TMEM176A and LOC105375566 is a neighbor of TMEM176B. Expression The gene is found to be most expressed in the liver with the kidney being the second most expressed tissue. ] Transcript variants There are 3 isoforms (A, B, C) of this gene with variants of isoform A and C. Isoform A variant 1 has 1444 nucleotides that encode 270 amino acids. There are 17 alternatively spliced variants with 1 unspliced transcript variant. Homology Paralogs There is one Sequence homology, paralog of TMEM176B which is TM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TMEM176B Tissue Expression
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells. Gene Location TMEM176B is also known as LR8, and MS4B2. The gene is found on the minus end of Chromosome 7, on the long arm at position 7q36.1. The starting position of the gene is at 150,791,287 and goes to 150,801,360. It has 10,074 base pairs and has a total of 11 exons. Gene TMEM176A and LOC105375566 is a neighbor of TMEM176B. Expression The gene is found to be most expressed in the liver with the kidney being the second most expressed tissue. ] Transcript variants There are 3 isoforms (A, B, C) of this gene with variants of isoform A and C. Isoform A variant 1 has 1444 nucleotides that encode 270 amino acids. There are 17 alternatively spliced variants with 1 unspliced transcript variant. Homology Paralogs There is one Sequence homology, paralog of TMEM176B which is TM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TMEM176B Unrooted Phylogenetic Tree
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells. Gene Location TMEM176B is also known as LR8, and MS4B2. The gene is found on the minus end of Chromosome 7, on the long arm at position 7q36.1. The starting position of the gene is at 150,791,287 and goes to 150,801,360. It has 10,074 base pairs and has a total of 11 exons. Gene TMEM176A and LOC105375566 is a neighbor of TMEM176B. Expression The gene is found to be most expressed in the liver with the kidney being the second most expressed tissue. ] Transcript variants There are 3 isoforms (A, B, C) of this gene with variants of isoform A and C. Isoform A variant 1 has 1444 nucleotides that encode 270 amino acids. There are 17 alternatively spliced variants with 1 unspliced transcript variant. Homology Paralogs There is one Sequence homology, paralog of TMEM176B which is T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TMEM176B Secondary Structure
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells. Gene Location TMEM176B is also known as LR8, and MS4B2. The gene is found on the minus end of Chromosome 7, on the long arm at position 7q36.1. The starting position of the gene is at 150,791,287 and goes to 150,801,360. It has 10,074 base pairs and has a total of 11 exons. Gene TMEM176A and LOC105375566 is a neighbor of TMEM176B. Expression The gene is found to be most expressed in the liver with the kidney being the second most expressed tissue. ] Transcript variants There are 3 isoforms (A, B, C) of this gene with variants of isoform A and C. Isoform A variant 1 has 1444 nucleotides that encode 270 amino acids. There are 17 alternatively spliced variants with 1 unspliced transcript variant. Homology Paralogs There is one Sequence homology, paralog of TMEM176B which is T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 7
Chromosome 7 is one of the 23 pairs of chromosomes in humans, who normally have two copies of this chromosome. Chromosome 7 spans about 159 million base pairs (the building material of DNA) and represents between 5 and 5.5 percent of the total DNA in cells. Genes Number of genes The following are some of the gene count estimates of human chromosome 7. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. Gene list The following is a partial list of genes on human chromosome 7. For complete list, see the link in the infobox on the right. Diseases and disorders The following diseases are some of those related to genes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sperm Whale
The sperm whale or cachalot (''Physeter macrocephalus'') is the largest of the toothed whales and the largest toothed predator. It is the only living member of the genus ''Physeter'' and one of three extant species in the sperm whale family, along with the pygmy sperm whale and dwarf sperm whale of the genus ''Kogia''. The sperm whale is a pelagic mammal with a worldwide range, and will migrate seasonally for feeding and breeding. Females and young males live together in groups, while mature males (bulls) live solitary lives outside of the mating season. The females cooperate to protect and nurse their young. Females give birth every four to twenty years, and care for the calves for more than a decade. A mature sperm whale has few natural predators, although calves and weakened adults are sometimes killed by pods of killer whales (orcas). Mature males average in length, with the head representing up to one-third of the animal's length. Plunging to , it is the third deep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspartic Acid
Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins. Like all other amino acids, it contains an amino group and a carboxylic acid. Its α-amino group is in the protonated –NH form under physiological conditions, while its α-carboxylic acid group is deprotonated −COO− under physiological conditions. Aspartic acid has an acidic side chain (CH2COOH) which reacts with other amino acids, enzymes and proteins in the body. Under physiological conditions (pH 7.4) in proteins the side chain usually occurs as the negatively charged aspartate form, −COO−. It is a non-essential amino acid in humans, meaning the body can synthesize it as needed. It is encoded by the codons GAU and GAC. D-Aspartate is one of two D-amino acids commonly found in mammals. .html" ;"title="/sup>">/sup> In proteins aspartate sidechains are often hydrogen bonded to form asx turns or asx motifs, which frequently occur at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α- carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, beans and legumes. It is encoded by all codons starting with GU (GUU, GUC, GUA, and GUG). History and etymology Valine was first isolated from casein in 1901 by Hermann Emil Fischer. The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of the acid in the roots of the plant. Nomenclature According to IUPAC, carbon atoms forming valine are numbered sequentially s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhesus Macaque
The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally brown or grey in colour, it is in length with a tail and weighs . It is native to South, Central, and Southeast Asia and has the widest geographic range of all non-human primates, occupying a great diversity of altitudes and a great variety of habitats, from grasslands to arid and forested areas, but also close to human settlements. Feral colonies are found in the United States, thought to be either released by humans or escapees after hurricanes destroyed zoo and wildlife park facilities. The rhesus macaque is diurnal, arboreal, and terrestrial. It is mostly herbivorous, mainly eating fruit, but will also consume seeds, roots, buds, bark, and cereals. Studies show almost 100 different plant species in its diet. Rhesus macaques are gener ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northern Pike
The northern pike (''Esox lucius'') is a species of carnivorous fish of the genus '' Esox'' (the pikes). They are typical of brackish and fresh waters of the Northern Hemisphere (''i.e.'' holarctic in distribution). They are known simply as a pike in Britain, Ireland, and most of Eastern Europe, Canada and the United States. Pike can grow to a relatively large size: the average length is about , with maximum recorded lengths of up to and published weights of . The IGFA currently recognizes a pike caught by Lothar Louis on Greffern Lake, Germany, on 16 October 1986, as the all-tackle world-record northern pike. Northern pike grow to larger sizes in Eurasia than in North America, and typically grow to larger sizes in coastal than inland regions of Eurasia. Etymology The northern pike gets its common name from its resemblance to the pole-weapon known as the pike (from the Middle English for 'pointed'). Various other unofficial trivial names are common pike, Lakes pike, great n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asian Arowana
The Asian arowana (''Scleropages formosus'') comprises several phenotypic varieties of freshwater fish distributed geographically across Southeast Asia. While most consider the different varieties to belong to a single species, work by Pouyaud ''et al.'' (2003) differentiates these varieties into multiple species. They have several other common names, including Asian bonytongue, dragonfish, and a number of names specific to the different color varieties. Native to Southeast Asia, Asian arowanas inhabit blackwater rivers, slow-moving waters flowing through forested swamps and wetlands. Adults feed on other fish, while juveniles feed on insects. These popular aquarium fish have special cultural significance in areas influenced by Chinese culture. The name 'dragonfish' stems from their resemblance to the Chinese dragon. This popularity has had both positive and negative effects on their status as endangered species. Evolution and taxonomy Like all members of the Osteoglossidae, As ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Koala
The koala or, inaccurately, koala bear (''Phascolarctos cinereus''), is an arboreal herbivorous marsupial native to Australia. It is the only extant representative of the family Phascolarctidae and its closest living relatives are the wombats. The koala is found in coastal areas of the mainland's eastern and southern regions, inhabiting Queensland, New South Wales, Victoria, and South Australia. It is easily recognisable by its stout, tailless body and large head with round, fluffy ears and large, spoon-shaped nose. The koala has a body length of and weighs . Fur colour ranges from silver grey to chocolate brown. Koalas from the northern populations are typically smaller and lighter in colour than their counterparts further south. These populations possibly are separate subspecies, but this is disputed. Koalas typically inhabit open ''Eucalyptus'' woodland, as the leaves of these trees make up most of their diet. Because this eucalypt diet has limited nutritional and calor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
West Indian Manatee
The West Indian manatee (''Trichechus manatus''), also known as the North American manatee, is a large, aquatic mammal native to warm coastal areas of the Caribbean, from the eastern US to northern Brazil. Living alone or in herds, it feeds on underwater plants and uses its whiskers to navigate. It is divided into two endangered subspecies, the Florida manatee (''T. m. latirostris'') in the US and the Antillean manatee (''T. m. manatus'') in the Caribbean, both of which face pressure from habitat loss, pollution, and other human activity. The West Indian manatee is the largest of the sirenians (order Sirenia), a group of large aquatic mammals that includes the dugong, other manatees, and the extinct Steller's sea cow. Manatees are herbivores, have developed vocal communication abilities, and are covered in highly sensitive whiskers (called vibrissae) that are used for feeding and navigation. In breeding season, several males form mating herds around an individual female; on aver ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
