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TEPP
Tetraethyl pyrophosphate, abbreviated TEPP, is an organophosphate compound with the formula . It is the tetraethyl derivative of pyrophosphate (P2O74-). It is a colorless oil that solidifies near room temperature. It is used as an insecticide. The compound hydrolyzes rapidly. Applications TEPP is an insecticide to aphids, mites, spiders, mealybugs, leafhoppers, lygus bugs, thrips, leafminers, and many other pests. TEPP and other organophosphates are the most widely used pesticides in the U.S. due to their effectiveness and relative small impact on the environment because this organophosphate breaks down so easily. TEPP has been used for treatment for myasthenia gravis, an autoimmune disease. The treatment would deliver an increase in strength. Synthesis The synthesis by De Clermont and Moschnin was based on the earlier work by Alexander Williamson (who is well known for the Williamson-synthesis of ethers). Their synthesis made use of ethyl iodide and silver salts to form este ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase Inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippe De Clermont
Philippe de Clermont (1831–1921) was a French organic chemist. He was known for the synthesis of the first organophosphate cholinesterase inhibitor (tetraethyl pyrophosphate, TEPP). He worked in Adolphe Wurtz Charles Adolphe Wurtz (; 26 November 181710 May 1884) was an Alsatian French chemist. He is best remembered for his decades-long advocacy for the atomic theory and for ideas about the structures of chemical compounds, against the skeptical opinio ...'s laboratory in Paris. Published works * ''Recherches sur les composés octyliques'' (1870). * ''Application du sulfure de manganèse comme conleur plastique'' (1890). @ OCLC WorldCat Identities References *[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticholinesterase
Cholinesterase inhibitors (ChEIs), also known as anti-cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine or butyrylcholine. This increases the amount of the acetylcholine or butyrylcholine in the synaptic cleft that can bind to muscarinic receptors, nicotinic receptors and others. This group of inhibitors is divided into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase inhibitors (BChEIs). ChEIs may be used as drugs for Alzheimer's and myasthenia gravis, and also as chemical weapons and insecticides. Side effects when used as drugs may include loss of appetite, nausea, vomiting, loose stools, vivid dreams at night, dehydration, rash, bradycardia, peptic ulcer disease, seizures, weight loss, rhinorrhea, salivation, muscle cramps, and fasciculations. ChEIs are indirect-acting parasympathomimetic drugs. ChEls are widely used as chemical weapons. Since November 2019 the group of ACheIs known as ''Novich ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organophosphate Compound
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or Aryl, aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and adenosine triphosphate, ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The American Chemical Society
The ''Journal of the American Chemical Society'' is a weekly peer-reviewed scientific journal that was established in 1879 by the American Chemical Society. The journal has absorbed two other publications in its history, the ''Journal of Analytical and Applied Chemistry'' (July 1893) and the ''American Chemical Journal'' (January 1914). It covers all fields of chemistry. Since 2021, the editor-in-chief is Erick M. Carreira (ETH Zurich). In 2014, the journal moved to a hybrid open access publishing model. Abstracting and indexing The journal is abstracted and indexed in Chemical Abstracts Service, Scopus, EBSCO databases, ProQuest databases, Index Medicus/MEDLINE/PubMed, and the Science Citation Index Expanded. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 16.383. Editors-in-chief The following people are or have been editor-in-chief: * 1879–1880 – Hermann Endemann * 1880–1881 – Gideon E. Moore * 1881–1882 – Hermann Endemann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atropine
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings. Common side effects include a dry mouth, large pupils, urinary retention, constipation, and a fast heart rate. It should generally not be used in people with angle closure glaucoma. While there is no evidence that its use during pregnancy causes birth defects, that has not been well studied. It is likely safe during breastfeeding. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system. Atropine occurs n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme Inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction. An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. Enzyme inhibitors may bind reversibly or irreversibly. Irreversible inhibitors form a chemical bond with the enzyme such that the enzyme is inhibited until the chemical bond is broken. By contrast, reversible inhibitors bind non-covalently and may spontaneously leave the enzyme, allowing the enzyme to resume its function. Reve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Schrader
Gerhard Schrader (25 February 1903 – 10 April 1990) was a German chemist specializing in the discovery of new insecticides, hoping to make progress in the fight against hunger in the world. Schrader is best known for his accidental discovery of nerve agents such as sarin and tabun, and for this he is sometimes called the "father of the nerve agents". Schrader was born in Bortfeld, near Wendeburg, Germany. He attended gymnasium in Braunschweig and later studied chemistry at Braunschweig University of Technology. He was later employed at the Bayer AG division of IG Farben. Schrader discovered several very effective insecticides, including bladan (the first fully synthetic contact insecticide Hexaethyl tetraphosphate being a constituent), and parathion (E 605). In 1936, while employed by the large German conglomerate IG Farben, he was experimenting with a class of compounds called organophosphates, which killed insects by interrupting their nervous systems. Instead of a new inse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Ministry Of Defence (Germany)
The Federal Ministry of Defence (german: Bundesministerium der Verteidigung, ), abbreviated BMVg, is a top-level federal agency, headed by the Federal Minister of Defence as a member of the Cabinet of Germany. The ministry is headquartered at the Hardthöhe district in Bonn and has a second office in the ''Bendlerblock'' building in Berlin. According to Article 65a of the German Constitution (''Grundgesetz)'', the Federal Minister of Defence is Commander-in-chief of the ''Bundeswehr'', the German armed forces, with around 265,019 active soldiers and civilians. Article 115b decrees that in the state of defence, declared by the Bundestag with consent of the Bundesrat, the command in chief passes to the Chancellor. The ministry currently has approximately 3,730 employees. Of these, 3,230 work in Bonn while around 500 work in the ''Bendlerblock'' building in Berlin. Organization On April 1, 2012, the Federal Ministry of Defence (DEU MOD) changes its organization to the follow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aleksandr Arbuzov
Aleksandr Erminingeldovich Arbuzov (russian: Алекса́ндр Ермининге́льдович Арбу́зов; 12 October 1877 – 22 January 1968) was a Russian and Soviet chemist who discovered the Michaelis–Arbuzov reaction. A native of Bilyarsk, Arbuzov studied in the Kazan University under Alexander Zaytsev. He graduated in 1900 and became professor at the same university in 1911. After World War II he was put in charge of the Soviet Institute of Organic Chemistry. Arbuzov was awarded the Stalin Prize Stalin Prize may refer to: * The State Stalin Prize in science and engineering and in arts, awarded 1941 to 1954, later known as the USSR State Prize The USSR State Prize (russian: links=no, Государственная премия СССР, ... in 1943. In addition to his scientific research, Arbuzov also wrote ''A Brief Sketch of the Development of Organic Chemistry in Russian'' (1948). References Further reading * * 1877 births 1968 deaths ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
