TrueAllele
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TrueAllele
TrueAllele is a software program by Cybergenetics that analyzes DNA using statistical methods, a process called probabilistic genotyping. It is used in forensic identification. The program can be used in situations unsuited to traditional methods, such as when a mixture of multiple people's DNA is in a sample. Some studies, mostly conducted by Cybergenetics' Chief Scientific Officer Mark W. Perlin, have validated the program's accuracy. In one study, TrueAllele distinguished between the genetic code of first-degree relatives with "great accuracy". The President's Council of Advisors on Science and Technology has noted that many validation studies were made by people affiliated with TrueAllele and are therefore not independent, demanding more independent research. In one case, TrueAllele's results differed from the results of STRMix, another probabilistic genotyping program, leading to the judge rejecting the DNA evidence. The proprietary nature of the code has led to concerns ov ...
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Probabilistic Genotyping
Probabilistic genotyping is the use of statistical methods and mathematical algorithms in DNA Profiling. It may be used instead of manual methods in difficult situations, such as when a DNA sample is very small or includes a mixture of multiple individuals' DNA. Probabilistic genotyping, unlike traditional methods, avoids the need for subjective judgment. The reliability of the method has been questioned by some defense lawyers because the source code of some probabilistic genotyping programs is proprietary {{Short pages monitor [Baidu]  


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Forensic Identification
Forensic identification is the application of forensic science, or "forensics", and technology to identify specific objects from the trace evidence they leave, often at a crime scene or the scene of an accident. Forensic means "for the courts". Human identification People can be identified by their fingerprints. This assertion is supported by the philosophy of friction ridge identification, which states that friction ridge identification is established through the agreement of friction ridge formations, in sequence, having sufficient uniqueness to individualize. Friction ridge identification is also governed by four premises or statements of facts: # Friction ridges develop on the fetus in their definitive form prior to birth. # Friction ridges are persistent throughout life except for permanent scarring, disease, or decomposition after death. # Friction ridge paths and the details in small areas of friction ridges are unique and never repeated. # Overall, friction ridge patterns ...
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Open Source
Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use the source code, design documents, or content of the product. The open-source model is a decentralized software development model that encourages open collaboration. A main principle of open-source software development is peer production, with products such as source code, blueprints, and documentation freely available to the public. The open-source movement in software began as a response to the limitations of proprietary code. The model is used for projects such as in open-source appropriate technology, and open-source drug discovery. Open source promotes universal access via an open-source or free license to a product's design or blueprint, and universal redistribution of that design or blueprint. Before the phrase ''open source'' became widely adopted, developers and producers have used a variety of other terms. ''Open source'' gained ...
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Probabilistic Software
Probability is the branch of mathematics concerning numerical descriptions of how likely an event is to occur, or how likely it is that a proposition is true. The probability of an event is a number between 0 and 1, where, roughly speaking, 0 indicates impossibility of the event and 1 indicates certainty."Kendall's Advanced Theory of Statistics, Volume 1: Distribution Theory", Alan Stuart and Keith Ord, 6th Ed, (2009), .William Feller, ''An Introduction to Probability Theory and Its Applications'', (Vol 1), 3rd Ed, (1968), Wiley, . The higher the probability of an event, the more likely it is that the event will occur. A simple example is the tossing of a fair (unbiased) coin. Since the coin is fair, the two outcomes ("heads" and "tails") are both equally probable; the probability of "heads" equals the probability of "tails"; and since no other outcomes are possible, the probability of either "heads" or "tails" is 1/2 (which could also be written as 0.5 or 50%). These conce ...
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