Trichloronate
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Trichloronate
Trichloronate is a highly toxic organophosphate insecticide. It is used against vegetable fly larvae and soil pests. Case reports indicate exposure to the chemical can cause fatal encephalopathy. Its aquatic toxicity has been measured at significantly higher against ''Ceriodaphnia dubia'' and ''Daphnia magna ''Daphnia magna'' is a small planktonic crustacean (adult length 1.5–5.0 mm) that belongs to the subclass Phyllopoda. Description ''D. magna'' is a typical water flea of the genus ''Daphnia''. The females reach up to 5 mm in size, ...''. References Acetylcholinesterase inhibitors Organophosphate insecticides Chlorobenzene derivatives Ethyl esters {{organic-compound-stub ...
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New Jersey Department Of Health And Senior Services
The New Jersey Department of Health (NJDOH) is a governmental agency of the U.S. state of New Jersey. New Jersey's State Board of Health was established in 1877. Its administrative functions were vested in the Department of Health, which was created in 1947. In 1996, the latter was renamed the Department of Health and Senior Services (DHSS). In 2012, senior services programs moved back into the Department of Human Services, and DHSS again became the Department of Health. Overview The department oversees numerous types of health facilities, for example hospitals, family planning, psychiatric hospitals, drug abuse treatment, primary care facilities, nursing homes, hospice care, assisted living, adult day care, and therapies and tests such as hemodialysis. There are four branches: Office of Policy and Strategic Planning, Office of Population Health, Health Systems, and Public Health Services. The department regulates medical marijuana in the state. Although it allows edibles to be c ...
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Toxic
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell ( cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large. Sometimes the word is more or less synonymous with poisoning in everyday usage. A central concept of toxicology is that the effects of a toxicant are dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass ...
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Organophosphate
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physica ...
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Insecticide
Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to be a major factor behind the increase in the 20th-century's agricultural productivity. Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans and/or animals; some become concentrated as they spread along the food chain. Insecticides can be classified into two major groups: systemic insecticides, which have residual or long term activity; and contact insecticides, which have no residual activity. The mode of action describes how the pesticide kills or inactivates a pest. It provides another way of classifying insecticides. Mode of action can be important in understanding whether an insecticide will be toxic to unrelated species, such as fish, birds and mammals. Insecticides may be repellent ...
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Aquatic Toxicity
Aquatic toxicology is the study of the effects of manufactured chemicals and other anthropogenic and natural materials and activities on aquatic organisms at various levels of organization, from subcellular through individual organisms to communities and ecosystems. Aquatic toxicology is a multidisciplinary field which integrates toxicology, aquatic ecology and aquatic chemistry. This field of study includes freshwater, marine water and sediment environments. Common tests include standardized acute and chronic toxicity tests lasting 24–96 hours (acute test) to 7 days or more (chronic tests). These tests measure endpoints such as survival, growth, reproduction, that are measured at each concentration in a gradient, along with a control test. Typically using selected organisms with ecologically relevant sensitivity to toxicants and a well-established literature background. These organisms can be easily acquired or cultured in lab and are easy to handle. History While basic resear ...
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Ceriodaphnia Dubia
''Ceriodaphnia dubia'' is a species of water flea in the class Branchiopoda, living in freshwater lakes, ponds, and marshes in most of the world. They are small, generally less than in length. Males are smaller than females. ''C. dubia'' moves using a powerful set of second antennae, and is used in toxicity testing of wastewater treatment plant effluent water in the United States. Climate change and particularly ultraviolet radiation B may seriously damage ''C. dubia'' populations, as they seems to be more sensitive than other cladocerans such as ''Daphnia pulex ''Daphnia pulex'' is the most common species of water flea. It has a cosmopolitan distribution: the species is found throughout the Americas, Europe, and Australia. It is a model species, and was the first crustacean to have its genome sequenced. ...'' or ''D. pulicaria''''.'' References Cladocera Crustaceans described in 1894 {{branchiopoda-stub ...
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Daphnia Magna
''Daphnia magna'' is a small planktonic crustacean (adult length 1.5–5.0 mm) that belongs to the subclass Phyllopoda. Description ''D. magna'' is a typical water flea of the genus ''Daphnia''. The females reach up to 5 mm in size, the males about 2 mm, thus they are among the largest species in the genus. The body is protected by a translucent carapace made of chitin, a transparent polysaccharide. It has a ventral opening and five pairs of thoracic limbs, used to help the filtering process. Spike rows run along the back of the carapace. The intestine is hook-shaped and has two digestive ceca. The head has two antennae and a large compound eye. Adult females can be distinguished from those of otherwise similar species such as '' D. pulex'' by the absence of a comb on the abdominal claw and the presence of two distinct combs on the abdomen. The males are smaller than the females and have larger first antennas, a diagnostic feature that distinguishes them from s ...
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Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely th ...
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Organophosphate Insecticides
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physica ...
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Chlorobenzene Derivatives
Chlorobenzene is an aromatic organic compound with the chemical formula C6H5Cl. This colorless, flammable liquid is a common solvent and a widely used intermediate in the manufacture of other chemicals. Uses Historical The major use of chlorobenzene is as an intermediate in the production of herbicides, dyestuffs, and rubber. Chlorobenzene is also used as a high-boiling solvent in industrial applications as well as in the laboratory. Chlorobenzene is nitrated on a large scale to give a mixture of 2-nitrochlorobenzene and 4-nitrochlorobenzene, which are separated. These mononitrochlorobenzenes are converted to related 2-nitrophenol, 2-nitroanisole, bis(2-nitrophenyl)disulfide, and 2-nitroaniline by nucleophilic displacement of the chloride, with respectively sodium hydroxide, sodium methoxide, sodium disulfide, and ammonia. The conversions of the 4-nitro derivative are similar. Chlorobenzene once was used in the manufacture of pesticides, most notably DDT, by reaction wit ...
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