Tetrahydrochrysene
Tetrahydrochrysene (THC) may refer to: * (''R'',''R'')-Tetrahydrochrysene ((''R'',''R'')-THC) * (''S'',''S'')-Tetrahydrochrysene ((''S'',''S'')-THC) {{Short pages monitor ...
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(R,R)-Tetrahydrochrysene
(''R'',''R'')-Tetrahydrochrysene ((''R'',''R'')-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (''R'',''R'')-THC is a silent antagonist of ERβ, and, uniquely relative to other known ERβ antagonists, a passive antagonist of the receptor. (''S'',''S'')-Tetrahydrochrysene ((''S'',''S'')-THC) also binds to the ERs, but in contrast to (''R'',''R'')-THC, (''S'',''S'')-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (''R'',''R'')-THC. See also * Propylpyrazoletriol (PPT) * PHTPP * Methylpiperidinopyrazole (MPP) * Diarylpropionitrile (DPN) * Prinaberel (ERB-041) * Liquiritigenin * Menerba * 2,8-DHHHC * Chrysene Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula that consists of four fused benzene rings. It is a natural constituent of coal tar, from which it was first isola ...
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