T-Distributed Stochastic Neighbour Embedding
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T-Distributed Stochastic Neighbour Embedding
t-distributed stochastic neighbor embedding (t-SNE) is a statistical method for visualizing high-dimensional data by giving each datapoint a location in a two or three-dimensional map. It is based on Stochastic Neighbor Embedding originally developed by Geoffrey Hinton and Sam Roweis, where Laurens van der Maaten and Hinton proposed the ''t''-distributed variant. It is a nonlinear dimensionality reduction technique for embedding high-dimensional data for visualization in a low-dimensional space of two or three dimensions. Specifically, it models each high-dimensional object by a two- or three-dimensional point in such a way that similar objects are modeled by nearby points and dissimilar objects are modeled by distant points with high probability. The t-SNE algorithm comprises two main stages. First, t-SNE constructs a probability distribution over pairs of high-dimensional objects in such a way that similar objects are assigned a higher probability while dissimilar points are ...
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Bioinformatics
Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, chemistry, physics, computer science, data science, computer programming, information engineering, mathematics and statistics to analyze and interpret biological data. The process of analyzing and interpreting data can sometimes be referred to as computational biology, however this distinction between the two terms is often disputed. To some, the term ''computational biology'' refers to building and using models of biological systems. Computational, statistical, and computer programming techniques have been used for In silico, computer simulation analyses of biological queries. They include reused specific analysis "pipelines", particularly in the field of genomics, such as by the identification of genes and single nucleotide polymorphis ...
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R (programming Language)
R is a programming language for statistical computing and Data and information visualization, data visualization. It has been widely adopted in the fields of data mining, bioinformatics, data analysis, and data science. The core R language is extended by a large number of R package, software packages, which contain Reusability, reusable code, documentation, and sample data. Some of the most popular R packages are in the tidyverse collection, which enhances functionality for visualizing, transforming, and modelling data, as well as improves the ease of programming (according to the authors and users). R is free and open-source software distributed under the GNU General Public License. The language is implemented primarily in C (programming language), C, Fortran, and Self-hosting (compilers), R itself. Preprocessor, Precompiled executables are available for the major operating systems (including Linux, MacOS, and Microsoft Windows). Its core is an interpreted language with a na ...
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Spectral Clustering
In multivariate statistics, spectral clustering techniques make use of the spectrum (eigenvalues) of the similarity matrix of the data to perform dimensionality reduction before clustering in fewer dimensions. The similarity matrix is provided as an input and consists of a quantitative assessment of the relative similarity of each pair of points in the dataset. In application to image segmentation, spectral clustering is known as segmentation-based object categorization. Definitions Given an enumerated set of data points, the similarity matrix may be defined as a symmetric matrix A, where A_\geq 0 represents a measure of the similarity between data points with indices i and j. The general approach to spectral clustering is to use a standard clustering method (there are many such methods, ''k''-means is discussed below) on relevant eigenvectors of a Laplacian matrix of A. There are many different ways to define a Laplacian which have different mathematical interpretatio ...
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Cluster Analysis
Cluster analysis or clustering is the data analyzing technique in which task of grouping a set of objects in such a way that objects in the same group (called a cluster) are more Similarity measure, similar (in some specific sense defined by the analyst) to each other than to those in other groups (clusters). It is a main task of exploratory data analysis, and a common technique for statistics, statistical data analysis, used in many fields, including pattern recognition, image analysis, information retrieval, bioinformatics, data compression, computer graphics and machine learning. Cluster analysis refers to a family of algorithms and tasks rather than one specific algorithm. It can be achieved by various algorithms that differ significantly in their understanding of what constitutes a cluster and how to efficiently find them. Popular notions of clusters include groups with small Distance function, distances between cluster members, dense areas of the data space, intervals or pa ...
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Gradient Descent
Gradient descent is a method for unconstrained mathematical optimization. It is a first-order iterative algorithm for minimizing a differentiable multivariate function. The idea is to take repeated steps in the opposite direction of the gradient (or approximate gradient) of the function at the current point, because this is the direction of steepest descent. Conversely, stepping in the direction of the gradient will lead to a trajectory that maximizes that function; the procedure is then known as ''gradient ascent''. It is particularly useful in machine learning for minimizing the cost or loss function. Gradient descent should not be confused with local search algorithms, although both are iterative methods for optimization. Gradient descent is generally attributed to Augustin-Louis Cauchy, who first suggested it in 1847. Jacques Hadamard independently proposed a similar method in 1907. Its convergence properties for non-linear optimization problems were first studied by Has ...
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Cauchy Distribution
The Cauchy distribution, named after Augustin-Louis Cauchy, is a continuous probability distribution. It is also known, especially among physicists, as the Lorentz distribution (after Hendrik Lorentz), Cauchy–Lorentz distribution, Lorentz(ian) function, or Breit–Wigner distribution. The Cauchy distribution f(x; x_0,\gamma) is the distribution of the -intercept of a ray issuing from (x_0,\gamma) with a uniformly distributed angle. It is also the distribution of the Ratio distribution, ratio of two independent Normal distribution, normally distributed random variables with mean zero. The Cauchy distribution is often used in statistics as the canonical example of a "pathological (mathematics), pathological" distribution since both its expected value and its variance are undefined (but see below). The Cauchy distribution does not have finite moment (mathematics), moments of order greater than or equal to one; only fractional absolute moments exist., Chapter 16. The Cauchy dist ...
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Student T-distribution
In probability theory and statistics, Student's  distribution (or simply the  distribution) t_\nu is a continuous probability distribution that generalizes the standard normal distribution. Like the latter, it is symmetric around zero and bell-shaped. However, t_\nu has heavier tails, and the amount of probability mass in the tails is controlled by the parameter \nu. For \nu = 1 the Student's distribution t_\nu becomes the standard Cauchy distribution, which has very "fat" tails; whereas for \nu \to \infty it becomes the standard normal distribution \mathcal(0, 1), which has very "thin" tails. The name "Student" is a pseudonym used by William Sealy Gosset in his scientific paper publications during his work at the Guinness Brewery in Dublin, Ireland. The Student's  distribution plays a role in a number of widely used statistical analyses, including Student's -test for assessing the statistical significance of the difference between two sample means, the cons ...
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Intrinsic Dimension
The intrinsic dimension for a data set can be thought of as the minimal number of variables needed to represent the data set. Similarly, in signal processing of multidimensional signals, the intrinsic dimension of the signal describes how many variables are needed to generate a good approximation of the signal. When estimating intrinsic dimension, however, a slightly broader definition based on manifold dimension is often used, where a representation in the intrinsic dimension does only need to exist locally. Such intrinsic dimension estimation methods can thus handle data sets with different intrinsic dimensions in different parts of the data set. This is often referred to as local intrinsic dimensionality. The intrinsic dimension can be used as a lower bound of what dimension it is possible to compress a data set into through dimension reduction, but it can also be used as a measure of the complexity of the data set or signal. For a data set or signal of ''N'' variables, its int ...
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Curse Of Dimensionality
The curse of dimensionality refers to various phenomena that arise when analyzing and organizing data in high-dimensional spaces that do not occur in low-dimensional settings such as the three-dimensional physical space of everyday experience. The expression was coined by Richard E. Bellman when considering problems in dynamic programming. The curse generally refers to issues that arise when the number of datapoints is small (in a suitably defined sense) relative to the intrinsic dimension of the data. Dimensionally cursed phenomena occur in domains such as numerical analysis, sampling, combinatorics, machine learning, data mining and databases. The common theme of these problems is that when the dimensionality increases, the volume of the space increases so fast that the available data become sparse. In order to obtain a reliable result, the amount of data needed often grows exponentially with the dimensionality. Also, organizing and searching data often relies on detecting a ...
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Perplexity
In information theory, perplexity is a measure of uncertainty in the value of a sample from a discrete probability distribution. The larger the perplexity, the less likely it is that an observer can guess the value which will be drawn from the distribution. Perplexity was originally introduced in 1977 in the context of speech recognition by Frederick Jelinek, Robert Leroy Mercer, Lalit R. Bahl, and James K. Baker. Perplexity of a probability distribution The perplexity ''PP'' of a discrete probability distribution ''p'' is a concept widely used in information theory, machine learning, and statistical modeling. It is defined as :\mathit(p) = \prod_x p(x)^ = b^ where ''x'' ranges over the events, where is defined to be , and where the value of does not affect the result; can be chosen to be 2, 10, , or any other positive value other than . In some contexts, this measure is also referred to as the '' (order-1 true) diversity''. The logarithm is the entropy of the d ...
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Density
Density (volumetric mass density or specific mass) is the ratio of a substance's mass to its volume. The symbol most often used for density is ''ρ'' (the lower case Greek letter rho), although the Latin letter ''D'' (or ''d'') can also be used: \rho = \frac, where ''ρ'' is the density, ''m'' is the mass, and ''V'' is the volume. In some cases (for instance, in the United States oil and gas industry), density is loosely defined as its weight per unit volume, although this is scientifically inaccurate this quantity is more specifically called specific weight. For a pure substance, the density is equal to its mass concentration. Different materials usually have different densities, and density may be relevant to buoyancy, purity and packaging. Osmium is the densest known element at standard conditions for temperature and pressure. To simplify comparisons of density across different systems of units, it is sometimes replaced by the dimensionless quantity "relative den ...
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