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Sérgio Henrique Ferreira
Sérgio Henrique Ferreira (October 4, 1934 – July 17, 2016) was a Brazilian physician and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti- hypertension drugs — the ACE inhibitors. Biography Ferreira received his M.D. from the Faculty of Medicine of Ribeirão Preto of the University of São Paulo (USP) and soon became staff member of the same school, where he was a member of the Department of Pharmacology. His research training in pharmacology initiated in this Department with Prof. Maurício Rocha e Silva, the discoverer of bradykinin. While working on this subject, he discovered a family of peptides present in the venom of a Brazilian snake, '' Bothrops jararaca'', which inhibited kininase activity and strongly potentiated the effects of bradykinin ''in vivo'' and ''in vitro''. This factor was named bradykinin potentiating factor, BPF. In 1968, with the collaboration of Dr. Lewis Joel Greene, from the Bro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franca
Franca is a municipality in the São Paulo (state), state of São Paulo, Brazil. The city is located in the northeastern portion of the state, distant 401 km (249 mi) from the state capital (São Paulo), and 676 km (420 mi) from Brasília, Brasilia. It covers a total area of 605,679 km² of which 86,92 km² comprises the urban area. As of the 2021 Census, the city's population was 358,539. In Brazil, the city is known as ''The National Capital of Footwear'', and ''The National Capital of Basketball''. The city is the industrial and economic center of an urban agglomerate comprising 19 municipalities with a total of 672.053 inhabitants, being consecutively among the top brazilian cities with the best urban sanitation. The parish of Franca was founded in 1805, being part of Mogi Mirim until 1824. The city status was received in 1856. History The history of Franca begins with the Bandeirantes, bandeiras of ''Bartolomeu Bueno da Silva'' (Bartolomeu Bueno da Silva, The Anhanguera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Medicine
Doctor of Medicine (abbreviated M.D., from the Latin language, Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. This generally arose because many in 18th-century medical professions trained in Scotland, which used the M.D. degree nomenclature. In England, however, Bachelor of Medicine, Bachelor of Surgery was used and eventually in the 19th century became the standard in Scotland too. Thus, in the United Kingdom, Republic of Ireland, Ireland and other countries, the M.D. is a research doctorate, honorary degree, honorary doctorate or applied clinical degree restricted to those who already hold a professional degree (Bachelor's/Master's/Doctoral) in medicine. In those countries, the equivalent professional degree to the North American, and some others use of M.D., is still typically titled Bachelor of Medicine, Bachelor of Surgery (M.B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London
London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a major settlement for two millennia. The City of London, its ancient core and financial centre, was founded by the Romans as '' Londinium'' and retains its medieval boundaries.See also: Independent city § National capitals The City of Westminster, to the west of the City of London, has for centuries hosted the national government and parliament. Since the 19th century, the name "London" has also referred to the metropolis around this core, historically split between the counties of Middlesex, Essex, Surrey, Kent, and Hertfordshire, which largely comprises Greater London, governed by the Greater London Authority.The Greater London Authority consists of the Mayor of London and the London Assembly. The London Mayor is distinguished fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novartis
Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-locations It is one of the largest pharmaceutical companies in the world. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; production ceased 2020), terbinafine (Lamisil), deferasirox (Exjade), and others. In March 1996, the companies Ciba-Geigy and Sandoz merged to form Novartis; the pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. Other Ciba-Geigy and Sandoz businesses were sold, or, like Ciba Specialty Chemicals, spun off as independent companies. The Sandoz brand ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bothrops
''Bothrops'' is a genus of highly venomous pit vipers endemic to Central and South America.McDiarmid RW, Campbell JA, Touré T. 1999. ''Snake Species of the World: A Taxonomic and Geographic Reference, vol. 1''. Herpetologists' League. 511 pp. (series). (volume). The generic name, ''Bothrops'', is derived from the Greek words βόθρος, ''bothros'', meaning "pit", and ώπς, ''ops'', meaning "eye" or "face", together an allusion to the heat-sensitive loreal pit organs. Members of this genus are responsible for more human deaths in the Americas than any other group of venomous snakes.Campbell JA, Lamar WW. 2004. ''The Venomous Reptiles of the Western Hemisphere''. Comstock Publishing Associates, Ithaca and London. 870 pp. 1500 plates. . Currently, 48 species are recognized. Description These snakes range from small, never growing to more than , to large at over in total length. Most are characterized by having a sharp ''canthus rostralis'' and an unelevated snout. The arra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bristol-Myers Squibb
The Bristol Myers Squibb Company (BMS) is an American multinational pharmaceutical company. Headquartered in New York City, BMS is one of the world's largest pharmaceutical companies and consistently ranks on the ''Fortune'' 500 list of the largest U.S. corporations. For fiscal 2021, it had a total revenue of $46.4 billion. Bristol Myers Squibb manufactures prescription pharmaceuticals and biologics in several therapeutic areas, including cancer, HIV/AIDS, cardiovascular disease, diabetes, hepatitis, rheumatoid arthritis, and psychiatric disorders. BMS's primary research and development (R&D) sites are located in Lawrence, New Jersey (formerly Squibb, near Princeton), Summit, New Jersey, formerly HQ of Celgene, New Brunswick, New Jersey, Redwood City, California, and Seville in Spain, with other sites in Devens and Cambridge, Massachusetts, East Syracuse, New York, Braine-l'Alleud, Belgium, Tokyo, Japan, Bangalore, India, and Wirral, United Kingdom. BMS previously had ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiotensin
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys. An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named 'angiotonin' or 'hypertensin') and subsequently characterized and synthesized by groups at the Cleveland Clinic and Ciba laboratories. Precursor and types Angiotensinogen Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as having many other roles not related to angiotensin peptides. It is a member of the serpin family of proteins, leading to another name: Serpin A8, although it is not known to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment camp. Its name stems from its location within the Town of Brookhaven, approximately 60 miles east of New York City. It is managed by Stony Brook University and Battelle Memorial Institute. Research at BNL includes nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. The 5,300 acre campus contains several large research facilities, including the Relativistic Heavy Ion Collider and National Synchrotron Light Source II. Seven Nobel Prizes have been awarded for work conducted at Brookhaven Lab. Overview BNL is staffed by approximately 2,750 scientists, engineers, technicians, and support personnel, and hosts 4,000 guest investigators every year. The laboratory has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewis Joel Greene
Lewis Joel Greene (born August 10, 1934) is an American Brazilian biochemist, scientist, university professor and editor of the '' Brazilian Journal of Medical and Biological Research''. Greene received a BA in liberal arts from Amherst College in 1955 and a PhD in biochemistry and cell biology at Rockefeller University in 1962. After his doctorate, he went to work for 12 years as a tenured researcher in the department of biology at Brookhaven National Laboratory. Upon an invitation to become a visiting scientist as a Fulbright scholar for a year at the department of pharmacology of the Faculty of Medicine of Ribeirão Preto of the University of São Paulo (USP) in 1968, Greene and his family decided to return and stay in the country in 1974 and was hired as a professor at the same school, where he is a full professor of cell and molecular biology and head of the Center for Protein Chemistry of Hemocentro de Ribeirão Preto. Greene has trained more than 40 masters and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bothrops Jararaca
''Bothrops jararaca'' — known as the ''jararaca'' or ''yarara'' — is a highly venomous pit viper species endemic to South America in southern Brazil, Paraguay, and northern Argentina. The specific name, ''jararaca'', is derived from the Tupi words and , which mean "large snake". Within its geographic range, it is often abundant and is an important cause of snakebite. No subspecies are currently recognized. The drugs known as angiotensin converting enzyme (ACE) inhibitors, used for the treatment of hypertension and some types of congestive heart failure, were developed from a peptide found in the venom of this species. Description This is a slender and terrestrial species that grows to a maximum total length of 160 cm (63 in), although the average total length is much less. The head scalation includes 5-12 intersupraoculars that are weakly keeled, 7-9 supralabials (usually 8) of which the second is fused with the prelacunal to form a lacunolabial, and 9-13 sub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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