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Stridex
Stridex (originally spelled Stri-Dex) is an American acne treatment and prevention medicine, originally registered trademark of Bayer Corporation. It comes in the form of fibrous pads saturated with astringents. Most products in the Stridex line contain as the active ingredient salicylic acid (0.5–2.5%); Stridex Power Pads instead contain benzoyl peroxide (2.5%), a nonprescription acne treatment medication. However, they also warn about possible side effects: dryness of the skin, possible burning, and tingling. Patients are advised to apply treatment with caution around lips, nose and mouth, or cuts and scrapes, and also avoid excessive sun exposure. In 2013, FDA started to investigate a possible link between benzoyl peroxide- and/or salicylic acid-based acne prevention medicine with hypersensitivity and anaphylactic reactions without calling off any products or placing warnings. Stridex were the first acne treatment pads to do so without requiring a prescription for purchase an ...
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Acne Vulgaris
Acne, also known as ''acne vulgaris'', is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles. Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily affects skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to anxiety, reduced self-esteem, and, in extreme cases, depression or thoughts of suicide. Susceptibility to acne is primarily genetic in 80% of cases. The roles of diet and cigarette smoking in the condition are unclear, and neither cleanliness nor exposure to sunlight appear to play a part. In both sexes, hormones called androgens appear to be part of the underlying mechanism, by causing increased production of sebum. Another common factor is the excessive growth of the bacterium ''Cutibacterium acnes'', which is present on the skin. Treatments for acne are ava ...
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Bayer Corporation
Bayer Corporation (also known as Bayer USA) is the American subsidiary of Bayer AG. Its main offices are located in Whippany, New Jersey. In addition it has 40 fully consolidated subsidiary companies located in 19 different states. History Bayer AG began marketing in the United States soon after the company's inception in Germany. In the late 1800s, they began to sell their trademark medication, aspirin. While the name "aspirin" became synonymous with Bayer for over a quarter of a century, the company's patents and trademarks were seized by the United States Office of Alien Property Custodian in 1917, due to Germany's enemy status in World War I. These assets were later auctioned and sold to Sterling Drug. Mobay In 1954, Bayer AG and Monsanto reached an agreement for establishment of a joint venture that was to be called Mobay. Initially established in St. Louis, Mobay established its headquarters in Pittsburgh, Pennsylvania in 1958, moving to a location in Robinson Township ...
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Astringents
An astringent (sometimes called adstringent) is a chemical that shrinks or constricts body tissues. The word derives from the Latin ''adstringere'', which means "to bind fast". Calamine lotion, witch hazel, and yerba mansa, a Californian plant, are astringents. Astringency, the dry, puckering or numbing mouthfeel caused by the tannins in unripe fruits, lets the fruit mature by deterring eating. Ripe fruits and fruit parts including blackthorn (sloe berries), ''Aronia'' chokeberry, chokecherry, bird cherry, rhubarb, quince and persimmon fruits (especially those which are unripe), banana skins (or unripe bananas), cashew fruits and acorns are astringent. Citrus fruits, like lemons, are somewhat astringent. Tannins, being a kind of polyphenol, bind salivary proteins and make them precipitate and aggregate, producing a rough, "sandpapery", or dry sensation in the mouth. The tannins in some teas, coffee, and red grape wines like Cabernet Sauvignon and Merlot produce mild astringency ...
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Salicylic Acid
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen. The name is from Latin ''salix'' for willow tree. It is an ingredient in some anti-acne products. Salts and esters of salicylic acid are known as salicylates. Uses Medicine Salicylic acid as a medication is commonly used to remove the outer layer of the skin. As such, it is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis. Similar to other hydroxy acids, salicylic acid is an ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis, and warts. Uses in manufacturing Salicylic acid is used as a food preservative ...
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Benzoyl Peroxide
Benzoyl peroxide is a chemical compound (specifically, an organic peroxide) with structural formula , often abbreviated as (BzO)2. In terms of its structure, the molecule can be described as two benzoyl (, Bz) groups connected by a peroxide (). It is a white granular solid with a faint odour of benzaldehyde, poorly soluble in water but soluble in acetone, ethanol, and many other organic solvents. Benzoyl peroxide is an oxidizer, but it is principally used as in the production of polymers. Benzoyl peroxide is mainly used in production of plastics and for bleaching flour, hair, plastics and textiles. Synthesis, structure, and chemical reactivity The original 1858 synthesis by Liebig reacted benzoyl chloride with barium peroxide, a reaction described by the following idealized equation: : Benzoyl peroxide is usually prepared by treating hydrogen peroxide with benzoyl chloride under alkaline conditions. : As in many other peroxides, the C-O-O-C linkage has a dihedral angle ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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Hypersensitivity
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune system and these reactions may be damaging and uncomfortable. This is an immunologic term and is not to be confused with the psychiatric term of being hypersensitive which implies to an individual who may be overly sensitive to physical (i.e. sound, touch, light, etc.) and/or emotional stimuli. Although there is a relation between the two – studies have shown that those individuals that have ADHD (a psychiatric disorder) are more likely to have hypersensitivity reactions such as allergies, asthma, eczema than those who do not have ADHD. Hypersensitivity reactions can be classified into four types. Type I: IgE mediated immediate reaction Type II: Antibody-mediated reaction (IgG or IgM antibodies) Type III: Immune complex-mediated rea ...
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Anaphylaxis
Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of use of emergency medication on site. It typically causes more than one of the following: an itchy rash, throat closing due to swelling which can obstruct or stop breathing; severe tongue swelling which can also interfere with or stop breathing; shortness of breath, vomiting, lightheadedness, loss of consciousness, low blood pressure, and medical shock. These symptoms typically start in minutes to hours and then increase very rapidly to life-threatening levels. Urgent medical treatment is required to prevent serious harm or death, even if the patient has used an epipen or has taken other medications in response, and even if symptoms appear to be improving. Common causes include allergies to insect bites and stings, allergies to foods – including nuts, milk, fish, shellfish, eggs and some fresh fruits or dried fruits; a ...
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National Museum Of American History
The National Museum of American History: Kenneth E. Behring Center collects, preserves, and displays the heritage of the United States in the areas of social, political, cultural, scientific, and military history. Among the items on display is the original Star-Spangled Banner (flag), Star-Spangled Banner. The museum is part of the Smithsonian Institution and located on the National Mall at 14th Street (Washington, D.C.), 14th Street and Constitution Avenue NW in Washington, D.C. History The museum opened in 1964 as the Museum of History and Technology. It was one of the last structures designed by the renowned architectural firm McKim Mead & White. In 1980, the museum was renamed the National Museum of American History to represent its mission of the collection, care, study, and interpretation of objects that reflect the experience of the American people. The museum site had previously held two Temporary buildings of the National Mall, temporary war buildings constructed in 194 ...
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Smithsonian Institution
The Smithsonian Institution ( ), or simply the Smithsonian, is a group of museums and education and research centers, the largest such complex in the world, created by the U.S. government "for the increase and diffusion of knowledge". Founded on August 10, 1846, it operates as a trust instrumentality and is not formally a part of any of the three branches of the federal government. The institution is named after its founding donor, British scientist James Smithson. It was originally organized as the United States National Museum, but that name ceased to exist administratively in 1967. Called "the nation's attic" for its eclectic holdings of 154 million items, the institution's 19 museums, 21 libraries, nine research centers, and zoo include historical and architectural landmarks, mostly located in the District of Columbia. Additional facilities are located in Maryland, New York, and Virginia. More than 200 institutions and museums in 45 states,States without Smithsonian ...
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