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Stria Terminalis
The stria terminalis (or terminal stria) is a structure in the brain consisting of a band of fibers running along the lateral margin of the ventricular surface of the thalamus. Serving as a major output pathway of the amygdala, the stria terminalis runs from its centromedial division to the ventromedial nucleus of the hypothalamus. Anatomy The stria terminalis covers the superior thalamostriate vein, marking a line of separation between the thalamus and the caudate nucleus as seen upon gross dissection of the ventricles of the brain, viewed from the superior aspect. The stria terminalis extends from the region of the interventricular foramina to the temporal horn of the lateral ventricle, carrying fibers from the amygdala to the septal nuclei, hypothalamic, and thalamic areas of the brain. It also carries fibers projecting from these areas back to the amygdala. Bed nucleus of the stria terminalis (BNST) The activity of the bed nucleus of the stria terminalis correlate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mouse Brain
The mouse brain refers to the brain of Mus musculus. Various brain atlases exist. For reasons of reproducibility, genetically characterized, stable strains like C57BL/6 were chosen to produce high-resolution images and databases. Well known online resources include: *Allen Brain Atlas * Mouse Brain LibraryHigh resolution mouse brain atlas* BrainMaps High-Resolution Brain Maps and Brain Atlases of ''Mus musculus'' Despite superficial differences, especially in size and weight, the mouse brain and its function can serve as a powerful animal model for study of human brain diseases or mental disorders (see e.g. Reeler, Chakragati mouse). This is because the genes responsible for building and operating both mouse and human brain are 90% identical. Transgenic mouse lines also allow neuroscientists to specifically target the labeling of certain cell types to probe the neural basis of fundamental processes. Anatomy The cerebral cortex of a mouse has around 8–14 million neurons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optogenetics
Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individual cells, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. In systems neuroscience, the ability to control the activity of a genetically defined set of neurons has been used to understand their contribution to decision making, learning, fear memory, mating, addiction, feeding, and locomotion. In a first medical application of optogenetic technology, vision was partially restored in a blind patient. Optogenetic techniques have also been introduced to map the functional connectivity of the brain''.'' By altering the activity of genetically labelled neurons with light and using imaging and electrophysiology techniques to record the activity of other cells, researchers can identify ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania
The University of Pennsylvania (also known as Penn or UPenn) is a Private university, private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universities by numerous organizations and scholars. While the university dates its founding to 1740, it was created by Benjamin Franklin and other Philadelphia citizens in 1749. It is a member of the Ivy League. The university has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the University of Pennsylvania College of Arts & Sciences, College of Arts and Sciences, the University of Pennsylvania School of Engineering and Applied Science, School of Engineering and Applied Science, the Wharton School of the University of Pennsylvania, Wharton School, and the University of Pennsylvania School of Nursing, School of Nursing. Among its highly ranked graduate schoo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paedophilia
Pedophilia ( alternatively spelt paedophilia) is a psychiatric disorder in which an adult or older adolescent experiences a primary or exclusive sexual attraction to prepubescent children. Although girls typically begin the process of puberty at age 10 or 11, and boys at age 11 or 12, criteria for pedophilia extend the cut-off point for prepubescence to age 13. According to DSM-5-TR, a person must be at least 16 years old, and at least five years older than the prepubescent child, for the attraction to be diagnosed as pedophilic disorder. Pedophilia is distinguished from pedophilic disorder in the current version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-5-TR) . The DSM-5-TR defines it as a paraphilic disorder involving intense and recurrent sexual urges, fantasies or behaviors about prepubescent children that have either been acted upon or which cause the person with the attraction distress or interpersonal difficulty. Similar to DSM-5-TR, the ICD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Startle Response
In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative affect.Rammirez-Moreno, David. "A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex". ''Biological Cybernetics'', 2012, p. 169 Usually the onset of the startle response is a startle reflex reaction. The startle reflex is a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli. It is found across many different species, throughout all stages of life. A variety of responses may occur depending on the affected individual's emotional state, body posture, preparation for execution of a motor task, or other activities. The startle response is implicated in the formation of specific phobias. Startl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormone Replacement Therapy
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal atrophy, accelerated skin aging, vaginal dryness, decreased muscle mass, sexual dysfunction, and bone loss or osteoporosis. They are in large part related to the diminished levels of sex hormones that occur during menopause. Estrogens and progestogens are the main hormone drugs used in HRT. Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens, unless the uterus has been removed, to avoid the increased risk of endometrial cancer. Unopposed estrogen therapy promotes endometrial hyperplasia and increases the risk of cancer, while p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gender Identity
Gender identity is the personal sense of one's own gender. Gender identity can correlate with a person's assigned sex or can differ from it. In most individuals, the various biological determinants of sex are congruent, and consistent with the individual's gender identity. Gender expression typically reflects a person's gender identity, but this is not always the case. While a person may express behaviors, attitudes, and appearances consistent with a particular gender role, such expression may not necessarily reflect their gender identity. The term ''gender identity'' was coined by psychiatry professor Robert J. Stoller in 1964 and popularized by psychologist John Money. In most societies, there is a basic division between gender attributes assigned to males and females, a gender binary to which most people adhere and which includes expectations of masculinity and femininity in all aspects of sex and gender: biological sex, gender identity, and gender expression. Some pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transsexual
Transsexual people experience a gender identity that is inconsistent with their assigned sex, and desire to permanently transition to the sex or gender with which they identify, usually seeking medical assistance (including sex reassignment therapies, such as hormone replacement therapy and sex reassignment surgery) to help them align their body with their identified sex or gender. The term ''transsexual'' is a subset of ''transgender'', but some transsexual people reject the label of ''transgender''. A medical diagnosis of gender dysphoria can be made if a person experiences marked and persistent incongruence between their experienced their personal sense of their own and their assigned sex. Understanding of transsexuality has changed very quickly in the 21st century. Many 20th century medical beliefs and practices around transsexuality are now considered deeply outdated. It was once classified as a mental disorder and subject to extensive gatekeeping by the medical est ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dick Swaab
Dick Ferdinand Swaab (born 17 December 1944) is a Dutch physician and neurobiologist (brain researcher). He is a professor of neurobiology at the University of Amsterdam and was until 2005 Director of the Netherlands Institute for Brain Research (Nederlands Instituut voor Hersenonderzoek) of the Royal Netherlands Academy of Arts and Sciences (Koninklijke Nederlandse Akademie van Wetenschappen). Life Swaab graduated at the Amsterdams Lyceum in 1963. He received his doctorate of medicine at the University of Amsterdam in 1968, and his Ph.D. in 1970 with professor J. Ariëns Kappers on a neuroendocrine thesis, and in 1972 he received his medical degree. He was from 1978 the director of the Netherlands Institute for Brain Research. In 1979 he was appointed professor of neurobiology at the University of Amsterdam. In 1985 he founded the Nederlandse Hersenbank—known in English as The Netherlands Brain Bank—to facilitate international research on brain diseases. Swaab is an atheist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trans Man
A trans man is a man who was assigned female at birth. The label of transgender man is not always interchangeable with that of transsexual man, although the two labels are often used in this way. ''Transgender'' is an umbrella term that includes different types of gender variant people (including transsexual people). Trans men have a male gender identity, and many trans men choose to undergo surgical or hormonal transition, or both (see sex reassignment therapy), to alter their appearance in a way that aligns with their gender identity or alleviates gender dysphoria. Although the literature indicates that most trans men identify as heterosexual (meaning they are sexually attracted to women), trans men, like cisgender men, can have any sexual orientation or sexual identity, and some trans men might consider conventional sexual orientation labels inadequate or inapplicable to them, in which case they may elect to use labels like '' queer.'' Terminology The umbrella ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trans Woman
A trans woman or a transgender woman is a woman who was assigned male at birth. Trans women have a female gender identity, may experience gender dysphoria, and may transition; this process commonly includes hormone replacement therapy and sometimes sex reassignment surgery, which can bring relief and resolve feelings of gender dysphoria. Like cisgender women, trans women may have any sexual orientation. The term '' transgender woman'' is not always interchangeable with '' transsexual woman'', although the terms are often used interchangeably. ''Transgender'' is an umbrella term that includes different types of gender variant people (including transsexual people). Trans women face significant discrimination in many areas of life, including in employment and access to housing, and face physical and sexual violence and hate crimes, including from partners; in the United States, discrimination is particularly severe towards trans women who are members of a racial minority, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormone Replacement Therapy
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal atrophy, accelerated skin aging, vaginal dryness, decreased muscle mass, sexual dysfunction, and bone loss or osteoporosis. They are in large part related to the diminished levels of sex hormones that occur during menopause. Estrogens and progestogens are the main hormone drugs used in HRT. Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens, unless the uterus has been removed, to avoid the increased risk of endometrial cancer. Unopposed estrogen therapy promotes endometrial hyperplasia and increases the risk of cancer, while p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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