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Strategies For Engineered Negligible Senescence
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease.de Grey, Aubrey; Rae, Michael (September 2007). ''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime''. New York, NY: St. Martin's Press, 416 pp. . SENS was first defined by British biogerontologist Aubrey de Grey. While some biogerontologists support the SENS program, others contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology. The 31-member Research Advisory Board of de Grey's SENS Research Foundation have signed an endorsement of the plausibility of the SENS approach. Framework The term "negligible senescence" was first used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differenti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Damage Theory Of Aging
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context is a DNA alteration that has an abnormal structure. Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell dysfunction). Several review articles have shown that deficient DNA repair, allowing greater accumulation of DNA damage, causes premature aging; and that increased DNA repair facilitates greater longevity. Mouse models of nucleotide-excision–repair syndromes reveal a striking correlation between the degree to which specific DNA repair pathways are compromised and the severity of accelerated aging, strongly suggesting a causal relationship. Human population studies show that single-nucleotide polymorphisms in D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Craig Venter
John Craig Venter (born October 14, 1946) is an American biotechnologist and businessman. He is known for leading one of the first draft sequences of the human genome and assembled the first team to transfect a cell with a synthetic chromosome. Venter founded Celera Genomics, the Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). He was the co-founder of Human Longevity Inc. and Synthetic Genomics. He was listed on ''Time'' magazine's 2007 and 2008 ''Time'' 100 list of the most influential people in the world. In 2010, the British magazine ''New Statesman'' listed Craig Venter at 14th in the list of "The World's 50 Most Influential Figures 2010". In 2012, Venter was honored with Dan David Prize for his contribution to genome research. He was elected to the American Philosophical Society in 2013. He is a member of the USA Science and Engineering Festival's advisory board. retrieved 2010-07-05 Early life and education Venter was born in Salt Lake ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vikram Sheel Kumar
Vikram Sheel Kumar (born 1976) is an American engineer, doctor, and entrepreneur. Early life and education Vikram Kumar was born in the United States to an Indian-American family. His father was a neurosurgeon. As a child, the family returned to India, where Kumar attended the Modern School in New Delhi. After graduation, he studied engineering at the Indian Institute of Technology. In 1996, Kumar returned to the United States, and received a BS in operations research from Columbia University in 1999. He then studied medicine and business at the Harvard-MIT Division of Health Sciences and Technology, which was supported by The Paul & Daisy Soros Fellowships for New Americans. Career In 2002, Kumar co-founded Dimagi, a for-profit software company which develops open-source software technology for doctors in impoverished areas. Kumar currently serves as the company's Chief Medical Officer (CMO). He also co-founded Cogito Corp, a startup which uses a mobile-phone based voice anal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nathan Myhrvold
Nathan Paul Myhrvold (born August 3, 1959), formerly Chief Technology Officer at Microsoft, is co-founder of Intellectual Ventures and the principal author of ''Modernist Cuisine'' and its successor books. Myhrvold was listed as co-inventor on 17 U.S. patents at Microsoft and is co-inventor on over 900 other U.S. patents issued to his corporation and its affiliates. Early life and education Myhrvold was born on August 3, 1959 in Seattle, Washington to Norwegian American parents. He was raised in Santa Monica, California, where he attended Mirman School and Santa Monica High School, graduating in 1974, and began college at age 14. Transferring from Santa Monica College, he studied mathematics (B.Sc.), and geophysics and space physics (Master's) at UCLA. He was awarded a Hertz Foundation Fellowship for graduate study and studied at Princeton University, where he earned a master's degree in mathematical economics and completed a Ph.D. in applied mathematics after completing a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anita Goel
Anita Goel is an American physicist, physician, and scientist in the emerging field of Nanobiophysics. At the Nanobiosym Research Institute (NBS), Goel examines the physics of life and the way nanomotors read and write information into DNA. Education Goel received a PhD and M.A. in physics from Harvard University, where she was worked with Nobel laureate Dudley R. Herschbach. Her thesis was entitled ''Single Molecule Dynamics of Motor Enzymes Along DNA''. She received a BS in physics with honors and distinction from Stanford University, where her honors thesis mentor was Nobel laureate Steven Chu. She also earned in parallel an M.D. from the Harvard–MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ... Joint Division of Health Sciences and Technology (HST). Career Go ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodney Brooks
Rodney Allen Brooks (born 30 December 1954) is an Australian roboticist, Fellow of the Australian Academy of Science, author, and robotics entrepreneur, most known for popularizing the actionist approach to robotics. He was a Panasonic Professor of Robotics at the Massachusetts Institute of Technology and former director of the MIT Computer Science and Artificial Intelligence Laboratory. He is a founder and former Chief Technical Officer of iRobot and co-Founder, Chairman and Chief Technical Officer of Rethink Robotics (formerly Heartland Robotics) and currently is the co-founder and Chief Technical Officer of Robust.AI (founded in 2019). Life Brooks received a M.A. in pure mathematics from Flinders University of South Australia. In 1981, he received a PhD in Computer Science from Stanford University under the supervision of Thomas Binford. He has held research positions at Carnegie Mellon University and MIT and a faculty position at Stanford University. He joined the faculty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methuselah Foundation
The Methuselah Foundation is an American-based global non-profit organization, based in Springfield, Virginia, with a declared mission to "make 90 the new 50 by 2030" by supporting tissue engineering and regenerative medicine therapies. The organization was originally incorporated by David Gobel in 2001 as the Performance Prize Society, a name inspired by the British governments Longitude Act, which offered monetary rewards for anyone who could devise a portable, practical solution for determining a ship's longitude. Founding In 2003, David Gobel, Aubrey de Grey, and Dane Gobel rebranded the organization Methuselah Foundation, named after Methuselah, the grandfather of Noah in the Hebrew Bible, whose lifespan was recorded as 969 years. The new name was introduced at the 32nd Annual Meeting of the American Aging Association, where they awarded the first Methuselah Mouse Prize to Andrej Bartke for his work on mice that lived the equivalent of 180 human years. The Foundation's wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Gobel
David Gobel (born 1952 in Baltimore, Maryland) is an American philanthropist, entrepreneur, inventor, and futurist. He is and CEO of the Methuselah Foundation, CEO of the Methuselah Fund, and one of the first to publicly advance the idea of longevity escape velocity, even before this term was formulate Career Methuselah Foundation David Gobel heads the Methuselah Foundation, a medical charity that was organized in 2000 and is based in Springfield, Virginia, Springfield, VA. Under Gobel's leadership, Methuselah has invested millions of dollars to support research and development in regenerative medicine, regenerative medicine, and is actively involved in efforts to change how the public thinks about extending the healthy human lifespan. With co-founders Dane Gobel and Aubrey de Grey, Gobel established Methuselah in order to, as stated on its original website, "shed light on the processes of aging and find ways to extend healthy life." The organization works in a variety of wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cambridge
, mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Scholars of the University of Cambridge , type = Public research university , endowment = £7.121 billion (including colleges) , budget = £2.308 billion (excluding colleges) , chancellor = The Lord Sainsbury of Turville , vice_chancellor = Anthony Freeling , students = 24,450 (2020) , undergrad = 12,850 (2020) , postgrad = 11,600 (2020) , city = Cambridge , country = England , campus_type = , sporting_affiliations = The Sporting Blue , colours = Cambridge Blue , website = , logo = University of Cambridge logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sherwin Nuland
Sherwin may refer to: Surname: * A. N. Sherwin-White (1911–1993), British historian of Ancient Rome *Adam Sherwin, journalist and a former media correspondent for The Times between 1999 and 2010 * Amy Sherwin (1855–1935), the 'Tasmanian Nightingale', an Australian soprano singer *Arthur Sherwin (1879–1947), English cricketer who played first-class cricket for Derbyshire *Belle Sherwin (1869–1955), American Women's rights activist *Brent Sherwin (born 1978), Australian professional rugby league player *Brian Sherwin (born 1980), American art critic, writer, and blogger with a degree from Illinois College *Byron Sherwin, Jewish scholar and author with expertise in theology, inter-religious dialogue, mysticism and Jewish ethics *Charles Sherwin (1877–1950), English cricketer who played first-class cricket for Derbyshire * David Sherwin (born 1942), British screenwriter * Derrick Sherwin (1936–2018), British television producer, writer, and actor *Emily Sherwin, American law ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
