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Splashed White
Splashed white or splash is a horse coat color pattern in the "overo" group of spotting patterns that produces pink-skinned, white markings. Many splashed whites have very modest markings, while others have the distinctive "dipped in white paint" pattern. Blue eyes are a hallmark of the pattern, and splash may account for otherwise "solid" blue-eyed horses. Splashed white occurs in a variety of geographically divergent breeds, from Morgans in North America to Kathiawari horses in India. The splashed white pattern is also associated with congenital deafness, though most splashed whites have normal hearing. Splashed white can be caused by multiple variants across two different genes, for which genetic testing is available. Characteristics The splashed white pattern is characterized by the appearance of having been dipped, feet-first, into white paint. Blue eyes are common, but not universal. The margins of the white markings are crisp, smooth, blocky, and well-defined.Brooks, S. ' ...
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Chestnut Splash White
The chestnuts are the deciduous trees and shrubs in the genus ''Castanea'', in the beech family Fagaceae. They are native to temperate regions of the Northern Hemisphere. The name also refers to the edible nuts they produce. The unrelated horse chestnuts (genus ''Aesculus'') are not true chestnuts, but are named for producing nuts of similar appearance that are mildly poisonous to humans. True chestnuts should also not be confused with water chestnuts, which are tubers of an aquatic herbaceous plant in the sedge family Cyperaceae. Other species commonly mistaken for chestnut trees are the chestnut oak (''Quercus prinus'') and the American beech (''Fagus grandifolia''),Chestnut Tree
in chestnuttree.net.
both of which are also in the Fagaceae family.

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American Quarter Horse
The American Quarter Horse, or Quarter Horse, is an American breed of horse that excels at sprinting short distances. Its name is derived from its ability to outrun other horse breeds in races of a quarter mile or less; some have been clocked at speeds up to 44 mph (70.8 km/h). The development of the Quarter Horse traces to the 1600s. The American Quarter Horse is the most popular breed in the United States today, and the American Quarter Horse Association is the largest breed registry in the world, with almost three million living American Quarter Horses registered in 2014. The American Quarter Horse is well known both as a race horse and for its performance in rodeos, horse shows, and as a working ranch horse. The compact body of the American Quarter Horse is well suited for the intricate and quick maneuvers required in reining, cutting, working cow horse, barrel racing, calf roping, and other western riding events, especially those involving live cattle. The Americ ...
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Welsh Pony
The Welsh Pony and Cob is a group of four closelyrelated horse breeds including both pony and cob types, which originated in Wales in the United Kingdom. The four sections within the breed society for the Welsh breeds are primarily distinguished by height, and also by variations in type: the smallest Welsh Mountain Pony (Section A); the slightly taller but refined Welsh Pony of riding type (Section B) popular as a children's show mount; the small but stocky Welsh Pony of Cob Type (Section C), popular for riding and competitive driving; and the tallest, the Welsh Cob (Section D), which can be ridden by adults. Welsh ponies and cobs in all sections are known for their good temperament, hardiness, and free-moving gaits. Native ponies existed in Wales before 1600 BC, and a Welsh-type cob was known as early as the Middle Ages. They were influenced by the Arabian horse, and possibly also by the Thoroughbred and the Hackney horse. In 1901, the first stud book for the Welsh breeds ...
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Finnhorse
The Finnhorse or Finnish Horse ( fi, suomenhevonen, literally "horse of Finland"; nickname: ''suokki'', or sv, finskt kallblod, literally "finnish cold-blood") is a horse breed with both riding horse and draught horse influences and characteristics, and is the only breed developed fully in Finland. In English it is sometimes called the Finnish Universal, as the Finns consider the breed capable of fulfilling all of Finland's horse needs, including agricultural and forestry work, harness racing, and riding. In 2007, the breed was declared the official national horse breed of Finland. The Finnhorse is claimed to be among the fastest and most versatile "coldblood" breeds in the world. In Finland, the term "universal horse" is used to describe the Finnhorse and breeds such as the Fjord horse that are relatively small with a body type that is heavy for a riding horse but light for a draught. There are four separate sections within the Finnhorse stud book, each with different goals: ...
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PAX3
The PAX3 (paired box gene 3) gene encodes a member of the paired box or PAX family of transcription factors. The PAX family consists of nine human (PAX1-PAX9) and nine mouse (Pax1-Pax9) members arranged into four subfamilies. Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. The human PAX3 gene is located in the 2q36.1 chromosomal region, and contains 10 exons within a 100 kb region. Transcript splicing Alternative splicing and processing generates multiple PAX3 isoforms that have been detected at the mRNA level. PAX3e is the longest isoform and consists of 10 exons that encode a 505 amino acid protein. In other mammalian species, including mouse, the longest mRNAs correspond to the human PAX3c and PAX3d isoforms, which consist of the first 8 or 9 exons of the PAX3 gene, respectively. Shorter PAX3 isoforms include mRNAs that skip exon 8 (PAX3g and PAX3h) and mRNAs containing 4 or 5 exons (PAX3a and PAX3b). In li ...
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Microphthalmia-associated Transcription Factor
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the ''MITF'' gene. MITF is a basic helix-loop-helix leucine zipper transcription factor involved in lineage-specific pathway regulation of many types of cells including melanocytes, osteoclasts, and mast cells. The term "lineage-specific", since it relates to MITF, means genes or traits that are only found in a certain cell type. Therefore, MITF may be involved in the rewiring of signaling cascades that are specifically required for the survival and physiological function of their normal cell precursors. MITF, together with transcription factor EB (TFEB), TFE3 and TFEC, belong to a subfamily of related bHLHZip proteins, termed the MiT-TFE family of transcription factors. The factors are able to form stable DNA-binding homo- and heterodimers. The gene that encodes for MITF resides at the ''mi'' locus in mice, and its protumor ...
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Reine De Since, Jument Splash White Overo
Reine is the administrative centre of Moskenes Municipality in Nordland county, Norway. The fishing village is located on the island of Moskenesøya in the Lofoten archipelago, above the Arctic Circle, about southwest of the town of Tromsø. Reine Church is located here and it serves the northern part of the municipality. The village has a population (2018) of 314 which gives the village a population density of . The local newspaper is the ''Lofotposten ''Lofotposten'' is a newspaper published in Lofoten, with its headquarters located in Svolvær. It is the biggest publication in Northern Norway. History and profile The newspaper was established by Joh. E. Paulsen in 1896. Following the occupatio ...''. Overview Reine has been a trading post since 1743. It was also a centre for the local fishing industry with a fleet of boats and facilities for fish processing and marketing. There was also a little light industry. In December 1941, the Germans burnt part of Reine in reprisa ...
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Brainstem Auditory Evoked Potentials
In human neuroanatomy, brainstem auditory evoked potentials (BAEPs), also called brainstem auditory evoked responses (BAERs), are very small auditory evoked potentials in response to an auditory stimulus, which are recorded by electrodes placed on the scalp. They reflect neuronal activity in the auditory nerve, cochlear nucleus, superior olive, and inferior colliculus of the brainstem. They typically have a response latency of no more than six milliseconds with an amplitude of approximately one microvolt. Due to their small amplitude, 500 or more repetitions of the auditory stimulus are required in order to average out the random background electrical activity. Although it is possible to obtain a BAEP to a pure tone stimulus in the hearing range, a more effective auditory stimulus contains a range of frequencies in the form of a short sharp click. Long and Allen were the first to report the abnormal BAEPs in an alcoholic woman who recovered from acquired central hypoventilation ...
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Hair Cell
Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. In mammals, the auditory hair cells are located within the spiral organ of Corti on the thin basilar membrane in the cochlea of the inner ear. They derive their name from the tufts of stereocilia called ''hair bundles'' that protrude from the apical surface of the cell into the fluid-filled cochlear duct. The stereocilia number from 50-100 in each cell while being tightly packed together and decrease in size the further away they are located from the kinocilium. The hair bundles are arranged as stiff columns that move at their base in response to stimuli applied to the tips. Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in ...
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Melanocyte
Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart. Melanin is a dark pigment primarily responsible for skin color. Once synthesized, melanin is contained in special organelles called melanosomes which can be transported to nearby keratinocytes to induce pigmentation. Thus darker skin tones have more melanosomes present than lighter skin tones. Functionally, melanin serves as protection against UV radiation. Melanocytes also have a role in the immune system. Function Through a process called melanogenesis, melanocytes produce melanin, which is a pigment found in the skin, eyes, hair, nasal cavity, and inner ear. This melanogenesis leads to a long-lasting pigmentation, which is in contrast to the pigmentation that originates from oxidation of already-existing melanin. There are both ...
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Congenital Deafness
Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language, and in adults it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness. Deaf people usually have little to no hearing. Hearing loss may be caused by a number of factors, including: genetics, ageing, exposure to noise, some infections, birth complications, trauma to the ear, and certain medications or toxins. A common condition that results in hearing loss is chronic ear infections. Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. He ...
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