Spectroscopic Optical Coherence Tomography
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Spectroscopic Optical Coherence Tomography
Spectroscopic optical coherence tomography (SOCT) is an optical imaging and sensing technique, which provides localized spectroscopic information of a sample based on the principles of optical coherence tomography (OCT) and low coherence interferometry. The general principles behind SOCT arise from the large optical bandwidths involved in OCT, where information on the spectral content of backscattered light can be obtained by detection and processing of the interferometric OCT signal. SOCT signal can be used to quantify depth-resolved spectra to retrieve the concentration of tissue chromophores (e.g., hemoglobin and bilirubin), characterize tissue light scattering, and/or used as a functional contrast enhancement for conventional OCT imaging. Theory The following discussion of techniques for quantitatively obtaining localized optical properties using SOCT is a summary of the concepts discussed in Bosscharrt ''et al.'' Localized Spectroscopic Information The general form of ...
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Optical Coherence Tomography
Optical coherence tomography (OCT) is an imaging technique that uses low-coherence light to capture micrometer-resolution, two- and three-dimensional images from within optical scattering media (e.g., biological tissue). It is used for medical imaging and industrial nondestructive testing (NDT). Optical coherence tomography is based on low-coherence interferometry, typically employing near-infrared light. The use of relatively long wavelength light allows it to penetrate into the scattering medium. Confocal microscopy, another optical technique, typically penetrates less deeply into the sample but with higher resolution. Depending on the properties of the light source ( superluminescent diodes, ultrashort pulsed lasers, and supercontinuum lasers have been employed), optical coherence tomography has achieved sub-micrometer resolution (with very wide-spectrum sources emitting over a ~100 nm wavelength range). Optical coherence tomography is one of a class of optical tom ...
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Short-time Fourier Transform
The short-time Fourier transform (STFT), is a Fourier-related transform used to determine the sinusoidal frequency and phase content of local sections of a signal as it changes over time. In practice, the procedure for computing STFTs is to divide a longer time signal into shorter segments of equal length and then compute the Fourier transform separately on each shorter segment. This reveals the Fourier spectrum on each shorter segment. One then usually plots the changing spectra as a function of time, known as a spectrogram or waterfall plot, such as commonly used in software defined radio (SDR) based spectrum displays. Full bandwidth displays covering the whole range of an SDR commonly use fast Fourier transforms (FFTs) with 2^24 points on desktop computers. Forward STFT Continuous-time STFT Simply, in the continuous-time case, the function to be transformed is multiplied by a window function which is nonzero for only a short period of time. The Fourier transform (a o ...
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Kramers–Kronig Relations
The Kramers–Kronig relations are bidirectional mathematical relations, connecting the real and imaginary parts of any complex function that is analytic in the upper half-plane. The relations are often used to compute the real part from the imaginary part (or vice versa) of response functions in physical systems, because for stable systems, causality implies the condition of analyticity, and conversely, analyticity implies causality of the corresponding stable physical system. The relation is named in honor of Ralph Kronig and Hans Kramers. In mathematics, these relations are known by the names Sokhotski–Plemelj theorem and Hilbert transform. Formulation Let \chi(\omega) = \chi_1(\omega) + i \chi_2(\omega) be a complex function of the complex variable \omega , where \chi_1(\omega) and \chi_2(\omega) are real. Suppose this function is analytic in the closed upper half-plane of \omega and vanishes faster than 1/, \omega, as , \omega, \to \infty. Slightly weaker conditi ...
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Least Squares
The method of least squares is a standard approach in regression analysis to approximate the solution of overdetermined systems (sets of equations in which there are more equations than unknowns) by minimizing the sum of the squares of the residuals (a residual being the difference between an observed value and the fitted value provided by a model) made in the results of each individual equation. The most important application is in data fitting. When the problem has substantial uncertainties in the independent variable (the ''x'' variable), then simple regression and least-squares methods have problems; in such cases, the methodology required for fitting errors-in-variables models may be considered instead of that for least squares. Least squares problems fall into two categories: linear or ordinary least squares and nonlinear least squares, depending on whether or not the residuals are linear in all unknowns. The linear least-squares problem occurs in statistical regressio ...
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Mie Scattering
The Mie solution to Maxwell's equations (also known as the Lorenz–Mie solution, the Lorenz–Mie–Debye solution or Mie scattering) describes the scattering of an electromagnetic plane wave by a homogeneous sphere. The solution takes the form of an infinite series of spherical multipole partial waves. It is named after Gustav Mie. The term ''Mie solution'' is also used for solutions of Maxwell's equations for scattering by stratified spheres or by infinite cylinders, or other geometries where one can write separate equations for the radial and angular dependence of solutions. The term ''Mie theory'' is sometimes used for this collection of solutions and methods; it does not refer to an independent physical theory or law. More broadly, the "Mie scattering" formulas are most useful in situations where the size of the scattering particles is comparable to the wavelength of the light, rather than much smaller or much larger. Mie scattering (sometimes referred to as a non-mol ...
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Numerical Aperture
In optics, the numerical aperture (NA) of an optical system is a dimensionless number that characterizes the range of angles over which the system can accept or emit light. By incorporating index of refraction in its definition, NA has the property that it is constant for a beam as it goes from one material to another, provided there is no refractive power at the interface. The exact definition of the term varies slightly between different areas of optics. Numerical aperture is commonly used in microscopy to describe the acceptance cone of an objective (and hence its light-gathering ability and resolution), and in fiber optics, in which it describes the range of angles within which light that is incident on the fiber will be transmitted along it. General optics In most areas of optics, and especially in microscopy, the numerical aperture of an optical system such as an objective lens is defined by :\mathrm = n \sin \theta, where is the index of refraction of the medium i ...
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Backscatter
In physics, backscatter (or backscattering) is the reflection of waves, particles, or signals back to the direction from which they came. It is usually a diffuse reflection due to scattering, as opposed to specular reflection as from a mirror, although specular backscattering can occur at normal incidence with a surface. Backscattering has important applications in astronomy, photography, and medical ultrasonography. The opposite effect is forward scatter, e.g. when a translucent material like a cloud diffuses sunlight, giving soft light. Backscatter of waves in physical space Backscattering can occur in quite different physical situations, where the incoming waves or particles are deflected from their original direction by different mechanisms: *Diffuse reflection from large particles and Mie scattering, causing alpenglow and gegenschein, and showing up in weather radar; * Inelastic collisions between electromagnetic waves and the transmitting medium (Brillouin scattering and ...
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Beer–Lambert Law
The Beer–Lambert law, also known as Beer's law, the Lambert–Beer law, or the Beer–Lambert–Bouguer law relates the attenuation of light to the properties of the material through which the light is travelling. The law is commonly applied to chemical analysis measurements and used in understanding attenuation in physical optics, for photons, neutrons, or rarefied gases. In mathematical physics, this law arises as a solution of the BGK equation. History The law was discovered by Pierre Bouguer before 1729, while looking at red wine, during a brief vacation in Alentejo, Portugal. It is often attributed to Johann Heinrich Lambert, who cited Bouguer's ''Essai d'optique sur la gradation de la lumière'' (Claude Jombert, Paris, 1729) – and even quoted from it – in his ''Photometria'' in 1760. Lambert's law stated that the loss of light intensity when it propagates in a medium is directly proportional to intensity and path length. Much later, the German scientist Augus ...
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Born Approximation
Generally in scattering theory and in particular in quantum mechanics, the Born approximation consists of taking the incident field in place of the total field as the driving field at each point in the scatterer. The Born approximation is named after Max Born who proposed this approximation in early days of quantum theory development. It is the perturbation method applied to scattering by an extended body. It is accurate if the scattered field is small compared to the incident field on the scatterer. For example, the scattering of radio waves by a light styrofoam column can be approximated by assuming that each part of the plastic is polarized by the same electric field that would be present at that point without the column, and then calculating the scattering as a radiation integral over that polarization distribution. Born approximation to the Lippmann–Schwinger equation The Lippmann–Schwinger equation for the scattering state \vert\rangle with a momentum p and out-going ...
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Wigner Distribution Function
The Wigner distribution function (WDF) is used in signal processing as a transform in time-frequency analysis. The WDF was first proposed in physics to account for quantum corrections to classical statistical mechanics in 1932 by Eugene Wigner, and it is of importance in quantum mechanics in phase space (see, by way of comparison: ''Wigner quasi-probability distribution'', also called the ''Wigner function'' or the ''Wigner–Ville distribution''). Given the shared algebraic structure between position-momentum and time-frequency conjugate pairs, it also usefully serves in signal processing, as a transform in time-frequency analysis, the subject of this article. Compared to a short-time Fourier transform, such as the Gabor transform, the Wigner distribution function provides the highest possible temporal vs frequency resolution which is mathematically possible within the limitations of the uncertainty principle. The downside is the introduction of large cross terms between every ...
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Bilinear Transform
The bilinear transform (also known as Tustin's method, after Arnold Tustin) is used in digital signal processing and discrete-time control theory to transform continuous-time system representations to discrete-time and vice versa. The bilinear transform is a special case of a conformal mapping (namely, a Möbius transformation), often used to convert a transfer function H_a(s) of a linear, time-invariant ( LTI) filter in the continuous-time domain (often called an analog filter) to a transfer function H_d(z) of a linear, shift-invariant filter in the discrete-time domain (often called a digital filter although there are analog filters constructed with switched capacitors that are discrete-time filters). It maps positions on the j \omega axis, \mathrm 0 , in the s-plane to the unit circle, , z, = 1 , in the z-plane. Other bilinear transforms can be used to warp the frequency response of any discrete-time linear system (for example to approximate the non-linear frequency ...
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Wavelet Transform
In mathematics, a wavelet series is a representation of a square-integrable (real number, real- or complex number, complex-valued) function (mathematics), function by a certain orthonormal series (mathematics), series generated by a wavelet. This article provides a formal, mathematical definition of an orthonormal wavelet and of the integral wavelet transform. Definition A function \psi \,\in\, L^2(\mathbb) is called an orthonormal wavelet if it can be used to define a Hilbert space#Orthonormal bases, Hilbert basis, that is a orthonormal basis, complete orthonormal system, for the Hilbert space L^2\left(\mathbb\right) of Square-integrable function, square integrable functions. The Hilbert basis is constructed as the family of functions \ by means of Dyadic transformation, dyadic translation (geometry), translations and dilation (operator theory), dilations of \psi\,, :\psi_(x) = 2^\frac \psi\left(2^jx - k\right)\, for integers j,\, k \,\in\, \mathbb. If under the standard ...
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