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Sir William Bowman, 1st Baronet
Sir William Bowman, 1st Baronet (20 July 1816 – 29 March 1892) was an English surgeon, histologist and anatomist. He is best known for his research using microscopes to study various human organs, though during his lifetime he pursued a successful career as an ophthalmologist. Life Born in Nantwich, Cheshire, third son of a banker and amateur botanist/geologist, Bowman attended Hazelwood School near Birmingham from 1826.Hale-White, W. (1935) "Sir William Bowman", pp. 177–188; in ''Great Doctors of the Nineteenth Century'', Edward Arnold & Co A childhood accident involving gunpowder is supposed to have interested him in medicine, and he was apprenticed to surgeon Joseph Hodgson at Birmingham General Hospital in 1832. He left Birmingham in 1837 to further his training as a surgeon and attended King's College London, where he served as a prosector under Robert Bentley Todd, a Professor of physiology. His earliest notable work was on the structure of striated muscle, for which h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nantwich
Nantwich ( ) is a market town and civil parish in the unitary authority of Cheshire East in Cheshire, England. It has among the highest concentrations of listed buildings in England, with notably good examples of Tudor and Georgian architecture. It had a population of 14,045 in 2021. History The origins of the settlement date to Roman times, when salt from Nantwich was used by the Roman garrisons at Chester (Deva Victrix) and Stoke-on-Trent as a preservative and a condiment. Salt has been used in the production of Cheshire cheese and in the tanning industry, both products of the dairy industry based in the Cheshire Plain around the town. ''Nant'' comes from the Welsh for brook or stream. ''Wich'' and ''wych'' are names used to denote brine springs or wells. In 1194 there is a reference to the town as being called ''Nametwihc'', which would indicate it was once the site of a pre-Roman Celtic nemeton or sacred grove. In the Domesday Book, Nantwich is recorded as having eight salt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Bentley Todd
Robert Bentley Todd (9 April 1809 – 30 January 1860) was an Irish-born physician who is best known for describing the condition postictal paralysis in his Lumleian Lectures in 1849 now known as Todd's palsy. Early life The son of physician Charles Hawkes Todd (1784–1826) and Elizabeth Bentley (1783–1862), Robert was born in Dublin, Ireland, 9 April 1809. He was the younger brother of noted writer and minister Rev. James Henthorn Todd, D.D. He is the older brother of Rev. William Gowan Todd, D.D. and Armstrong Todd, MD. Robert attended day school and was tutored by the Rev. William Higgin (1793–1867), who later became bishop of the Diocese of Derry and Raphoe. Todd entered Trinity College, Dublin in 1825, intending to study for the bar. When his father died the next year, he switched to medicine and became a resident pupil at a hospital in Dublin. He was a student of Robert Graves, and graduated B.A. at Trinity in 1829. He became licensed at the Royal College ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moorfields Eye Hospital
Moorfields Eye Hospital is a specialist NHS eye hospital in Finsbury in the London Borough of Islington in London, England run by Moorfields Eye Hospital NHS Foundation Trust. Together with the UCL Institute of Ophthalmology, which is adjacent to the hospital, it is the oldest and largest centre for ophthalmic treatment, teaching and research in Europe. History Moorfields Eye Hospital was founded at Charterhouse Square in 1805 as the London Dispensary for curing diseases of the Eye and Ear, by John Cunningham Saunders, assisted by John Richard Farre. It moved to a site on the former Moorfields in 1822, before moving to its present site in 1899, and became part of the National Health Service in 1948. These anniversaries gave it the unique ability to celebrate a centenary in 1999 and a bicentenary in 2005. In February 2007, the new Richard Desmond Children's Eye Centre (RDCEC), was opened by the Queen. Its location is adjacent to the hospital's main City Road building. In Decem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornea
The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is approximately 43 dioptres. The cornea can be reshaped by surgical procedures such as LASIK. While the cornea contributes most of the eye's focusing power, its focus is fixed. Accommodation (the refocusing of light to better view near objects) is accomplished by changing the geometry of the lens. Medical terms related to the cornea often start with the prefix "'' kerat-''" from the Greek word κέρας, ''horn''. Structure The cornea has unmyelinated nerve endings sensitive to touch, temperature and chemicals; a touch of the cornea causes an involuntary reflex to close the eyelid. Because transparency is of prime importance, the healthy cornea does not have or need blood vessels with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bowman's Membrane
The Bowman layer (Bowman's membrane, anterior limiting lamina, anterior elastic lamina) is a smooth, acellular, nonregenerating layer, located between the superficial epithelium and the stroma in the cornea of the eye. It is composed of strong, randomly oriented collagen fibrils in which the smooth anterior surface faces the epithelial basement membrane and the posterior surface merges with the collagen lamellae of the corneal stroma proper. In adult humans, Bowman layer is 8-12 μm thick. With ageing, this layer becomes thinner. The function of the Bowman layer remains unclear and appears to have no critical function in corneal physiology. Recently, it is postulated that the layer may act as a physical barrier to protect the subepithelial nerve plexus and thereby hastens epithelial innervation and sensory recovery. Moreover, it may also serve as a barrier that prevents direct traumatic contact with the corneal stroma and hence it is highly involved in stromal wound healing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olfactory Mucosa
The olfactory mucosa is located in the upper region of the nasal cavity and is made up of the olfactory epithelium and the underlying lamina propria, connective tissue containing fibroblasts, blood vessels, Bowman's glands and bundles of fine axons from the olfactory neurons. The mucus protects the olfactory epithelium and allows odors to dissolve so that they can be detected by olfactory receptor neurons. Electron microscopy studies show that Bowman's glands contain cells with large secretory vesicles. The exact composition of the secretions from Bowman's glands is unclear, but there is evidence that they produce odorant binding protein. In vertebrates, the olfactory epithelium consists of a three basic cell types: bipolar olfactory receptor neurons; sustentacular cells, a type of supporting cell; and basal cells, the stem cells that continuously give rise to new olfactory receptor neurons and sustentacular cells. Cells in the olfactory mucosa have been used in clinical trials ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bowman's Glands
Olfactory glands, also known as Bowman's glands, are a type of nasal gland situated in the olfactory mucosa, beneath the olfactory epithelium, in the lamina propria, a connective tissue also containing fibroblasts, blood vessels and bundles of fine axons from the olfactory neurons. An olfactory gland consists of an acinus in the lamina propria and a secretory duct going out through the olfactory epithelium. Electron microscopy studies show that olfactory glands contain cells with large secretory vesicles. Olfactory glands secrete the gel-forming mucin protein MUC5B. They might secrete proteins such as lactoferrin, lysozyme, amylase and IgA, similarly to serous glands. The exact composition of the secretions from olfactory glands is unclear, but there is evidence that they produce odorant-binding protein. Function The Olfactory glands are tubuloalveolar glands surrounded by Olfactory receptors Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histology
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope. Although one may divide microscopic anatomy into ''organology'', the study of organs, ''histology'', the study of tissues, and ''cytology'', the study of cells, modern usage places all of these topics under the field of histology. In medicine, histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. In the field of paleontology, the term paleohistology refers to the histology of fossil organisms. Biological tissues Animal tissue classification There are four basic types of animal tissues: muscle tissue, nervous tissue, connective tissue, and epithelial tissue. All animal tissues are considered to be subtypes of these four principal tissue types ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kidney
The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins. Each kidney is attached to a ureter, a tube that carries excreted urine to the bladder. The kidney participates in the control of the volume of various body fluids, fluid osmolality, acid–base balance, various electrolyte concentrations, and removal of toxins. Filtration occurs in the glomerulus: one-fifth of the blood volume that enters the kidneys is filtered. Examples of substances reabsorbed are solute-free water, sodium, bicarbonate, glucose, and amino acids. Examples of substances secreted are hydrogen, ammonium, potassium and uric acid. The nephron is the structural and functional unit of the kidney. Each adult human kidney contains around 1 million nephrons, while a mouse kidney contains on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal Corpuscle
A renal corpuscle (also called malpighian body) is the blood-filtering component of the nephron of the kidney. It consists of a glomerulus - a tuft of capillaries composed of endothelial cells, and a glomerular capsule known as Bowman's capsule. Structure The renal corpuscle is composed of two structures, the glomerulus and the Bowman's capsule. The glomerulus is a small tuft of capillaries containing two cell types. Endothelial cells, which have large fenestrae, are not covered by diaphragms. Mesangial cells are modified smooth muscle cells that lie between the capillaries. They regulate blood flow by their contractile activity and secrete extracellular matrix, prostaglandins, and cytokines. Mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier. The Bowman's capsule has an outer parietal layer composed of simple squamous epithelium. The visceral layer, composed of modified ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nephron
The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure called Bowman's capsule. The renal tubule extends from the capsule. The capsule and tubule are connected and are composed of epithelial cells with a lumen. A healthy adult has 1 to 1.5 million nephrons in each kidney. Blood is filtered as it passes through three layers: the endothelial cells of the capillary wall, its basement membrane, and between the foot processes of the podocytes of the lining of the capsule. The tubule has adjacent peritubular capillaries that run between the descending and ascending portions of the tubule. As the fluid from the capsule flows down into the tubule, it is processed by the epithelial cells lining the tubule: water is reabsorbed and substances are exchanged (some are added, others are removed); first with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bowman's Capsule
Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. A glomerulus is enclosed in the sac. Fluids from blood in the glomerulus are collected in the Bowman's capsule. Structure Outside the capsule, there are two "poles": * The vascular pole is the side with the afferent arteriole and efferent arteriole. * The urinary pole is the side with the proximal convoluted tubule. Inside the capsule, the layers are as follows, from outside to inside: *''Parietal layer''—A single layer of simple squamous epithelium. Does not function in filtration. *''Bowman's space (or "urinary space", or "capsular space")''—Between the visceral and parietal layers, into which the filtrate enters after passing through the filtration slits. *''Visceral layer''—Lies just above the thickened glomerular baseme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
