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Sir Alexander Fleming Building
Sir Alexander Fleming (6 August 1881 – 11 March 1955) was a Scottish physician and microbiologist, best known for discovering the world's first broadly effective antibiotic substance, which he named penicillin. His discovery in 1928 of what was later named benzylpenicillin (or penicillin G) from the mould ''Penicillium rubens'' is described as the "single greatest victory ever achieved over disease." For this discovery, he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain. He also discovered the enzyme lysozyme from his nasal discharge in 1922, and along with it a bacterium he named ''Micrococcus Lysodeikticus'', later renamed ''Micrococcus luteus''. Fleming was knighted for his scientific achievements in 1944. In 1999, he was named in ''Time'' magazine's list of the 100 Most Important People of the 20th century. In 2002, he was chosen in the BBC's television poll for determining the 100 Greatest Britons, and in 2009, he was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Darvel
Darvel ( sco, Dairvel, gd, Darbhail) is a small town in East Ayrshire, Scotland. It is at the eastern end of the Loudoun, Irvine Valley and is sometimes referred to as "The Lang Toon" ( en, the Long Town). The town's Latin motto, , means "Not for ourselves, but for others". Location Darvel is situated on the A71 road that runs from Irvine on the west coast to Edinburgh on the east. The town is east of Kilmarnock and is the most easterly of the Irvine Valley Towns, the others being Galston, East Ayrshire, Galston and Newmilns. The town was once linked with Stonehouse, South Lanarkshire, Stonehouse (via Strathaven) by the Caledonian Railway. However, the line was closed by the LMS before the Second World War. The former Glasgow and South Western Railway branch line to Kilmarnock survived for much longer and was closed in 1964 as part of the Beeching Axe. Much of the route of both lines is still in existence, although the rails have long since gone and many road bridges have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal College Of Surgeons Of England
The Royal College of Surgeons of England (RCS England) is an independent professional body and registered charity that promotes and advances standards of surgical care for patients, and regulates surgery and dentistry in England and Wales. The College is located at Lincoln's Inn Fields in London. It publishes multiple medical journals including the ''Annals of the Royal College of Surgeons of England'', the '' Faculty Dental Journal'', and the '' Bulletin of the Royal College of Surgeons of England''. History The origins of the college date to the fourteenth century with the foundation of the "Guild of Surgeons Within the City of London". Certain sources date this as occurring in 1368. There was ongoing dispute between the surgeons and barber surgeons until an agreement was signed between them in 1493, giving the fellowship of surgeons the power of incorporation. This union was formalised further in 1540 by Henry VIII between the Worshipful Company of Barbers (incorporated 146 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
100 Greatest Britons
''100 Greatest Britons'' is a television series that was broadcast by the BBC in 2002. It was based on a television poll conducted to determine who the British people at that time considered the greatest Britons in history. The series included individual programmes featuring the top ten, with viewers having further opportunity to vote after each programme. It concluded with a debate and final determination of the ranking of the top ten. Although many living people were included among the top 100, all of the top ten were deceased. Poll The poll resulted in nominees including Guy Fawkes, who was executed because of his role in the plot to blow up the Parliament of England; Oliver Cromwell, who created a republican British state (the Commonwealth of England, Scotland, and Ireland); Richard III, suspected of murdering his nephews; James Connolly, an Irish nationalist and socialist who was executed by the Crown due to his part in the 1916 Easter Rising; Thomas Paine, who wrote against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Most Important People Of The Century
''Time'' 100: The Most Important People of the Century is a compilation of the 20th century's 100 most influential people, published in ''Time'' magazine in 1999. The idea for such a list started on February 1, 1998, with a debate at a symposium in Hanoi, Vietnam. The panel participants were former '' CBS Evening News'' anchor Dan Rather, historian Doris Kearns Goodwin, former New York governor Mario Cuomo, then–Stanford Provost Condoleezza Rice, publisher Irving Kristol, and ''Time'' managing editor Walter Isaacson. In a separate issue on December 31, 1999, ''Time'' recognized Albert Einstein as the Person of the Century. List categories ''Time''s article cites twenty persons in each of five broad categories: Leaders and Revolutionaries, Scientists and Thinkers, Builders and Titans, Artists and Entertainers, and Heroes and Icons. Person of the Century Of the 100 chosen, Albert Einstein was chosen as the Person of the Century, on the grounds that he was the preeminent scie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time (magazine)
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published Weekly newspaper, weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orders, Decorations, And Medals Of The United Kingdom
In the United Kingdom and the British Overseas Territories, personal bravery, achievement, or service are rewarded with honours. The honours system consists of three types of award: *Honours are used to recognise merit in terms of achievement and service; *Decorations tend to be used to recognise specific deeds; *Medals are used to recognise service on a particular operation or in a specific theatre, long or valuable service, and good conduct. Appointments to the various orders and awards of other honours are usually published in ''The London Gazette''. Brief history Although the Anglo-Saxon monarchs are known to have rewarded their loyal subjects with rings and other symbols of favour, it was the Normans who introduced knighthoods as part of their feudal government. The first English order of chivalry, the Order of the Garter, was created in 1348 by Edward III. Since then, the system has evolved to address the changing need to recognise other forms of service to the Unit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micrococcus Luteus
''Micrococcus luteus'' is a Gram-positive, to Gram-variable, nonmotile, coccus, tetrad-arranging, pigmented, saprotrophic bacterium that belongs to the family Micrococcaceae. It is urease and catalase positive. An obligate aerobe, ''M. luteus'' is found in soil, dust, water and air, and as part of the normal microbiota of the mammalian skin. The bacterium also colonizes the human mouth, mucosae, oropharynx and upper respiratory tract. ''Micrococcus luteus'' is considered a contaminant in sick patients and is resistant by slowing of major metabolic processes and induction of unique genes. It is a high G + C ratio bacterium. ''Micrococcus luteus'' is coagulase negative, bacitracin susceptible, and forms bright yellow colonies on nutrient agar. ''Micrococcus luteus'' has been shown to survive in oligotrophic environments for extended periods of time. Recent work by Greenblatt ''et al.'' demonstrate that ''Micrococcus luteus'' has survived for at least 34,000 to 170,000 ye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Boris Chain
Sir Ernst Boris Chain (19 June 1906 – 12 August 1979) was a German-born British biochemist best known for being a co-recipient of the Nobel Prize in Physiology or Medicine for his work on penicillin. Life and career Chain was born in Berlin, the son of Margarete () and Michael Chain, a chemist and industrialist dealing in chemical products. His family was of both Sephardic and Ashkenazi Jewish descent. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin. In 1930, he received his degree in chemistry from Friedrich Wilhelm University. His father descends from Zerahiah ben Shealtiel Ḥen who was a prominent figure among the Catalonian Jewry and whose ancestors were leading Jewish figures in Babylonia. He was a lifelong friend of Professor Albert Neuberger, whom he met in Berlin in the 1930s. After the Nazis came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to Englan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Florey
Howard Walter Florey, Baron Florey (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey who carried out the first clinical trials of penicillin in 1941 at the Radcliffe Infirmary in Oxford on the first patient, a police constable from Oxford. The patient started to recover, but subsequently died because Florey was unable, at that time, to make enough penicillin. It was Florey and Chain who actually made a useful and effective drug out of penicillin, after the task had been abandoned as too difficult. Florey's discoveries, along with the discoveries of Fleming and Ernst Chain, are estimated to have saved over 200 million lives, and he is consequently regarded by the Australian scientific and medical comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillium Rubens
''Penicillium rubens'' is a species of fungus in the genus ''Penicillium'' and was the first species known to produce the antibiotic penicillin. It was first described by Philibert Melchior Joseph Ehi Biourge in 1923. For the discovery of penicillin from this species Alexander Fleming shared the Nobel Prize in Physiology or Medicine in 1945. The original penicillin-producing type has been variously identified as ''Penicillium rubrum'', ''P. notatum'', and ''Penicillium chrysogenum, P. chrysogenum'' among others, but genomic comparison and phylogenetic analysis in 2011 resolved that it is ''P. rubens.'' It is the best source of penicillins and produces benzylpenicillin (G), phenoxymethylpenicillin (V) and octanoylpenicillin (K). It also produces other important bioactive compounds such as Andrastin A, andrastin, chrysogine, fungisporin, roquefortine, and sorbicillins. History A French microbiologist Philibert Melchior Joseph Ehi Biourge was the first to describe ''P. rubens'' in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzylpenicillin
Benzylpenicillin, also known as penicillin G (PenG) or BENPEN, and in military slang "Peanut Butter Shot" is an antibiotic used to treat a number of bacterial infections. This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis, cellulitis, and tetanus. It is not a first-line agent for pneumococcal meningitis. Due to Benzylpenicillin's limited bioavailability for oral medications, it is generally taken as an injection in the form of a sodium, potassium, benzathine, or procaine salt. Benzylpenicillin is given by injection into a vein or muscle. Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle. Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis. When used to treat syphilis or Lyme disease a reaction known as Jarisch–Herxheimer may occur. It is not recommended in those with a history of penicillin allergy. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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