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Sidney Pestka
Sidney Pestka (May 29, 1936 – December 22, 2016) was an American biochemist and geneticist. A recipient of the National Medal of Technology, he is sometimes referred to as the "father of interferon" for his groundbreaking work developing the interferons as treatments for major diseases such as hepatitis, multiple sclerosis, and cancer. Pestka was part of the team working on research involving the genetic code, protein synthesis and ribosome function that led to the 1968 Nobel Prize in Physiology or Medicine received by Marshall Warren Nirenberg. Early life and education Sidney Pestka was born on May 29, 1936 in the Polish town of Drobin, which is located in what is now known as Płock County ("powiat płocki"). His family emigrated to the United States a few years later. When he was a young boy, he began inventing devices. "It was stimulating to see chemicals change the color of fluids, to construct crystal radios, and to make caramel from sugar—however, my mother’s pots and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Medal Of Technology
The National Medal of Technology and Innovation (formerly the National Medal of Technology) is an honor granted by the President of the United States to American inventors and innovators who have made significant contributions to the development of new and important technology. The award may be granted to a specific person, to a group of people or to an entire organization or corporation. It is the highest honor the United States can confer to a US citizen for achievements related to technological progress. History The National Medal of Technology was created in 1980 by the United States Congress under the Stevenson-Wydler Technology Innovation Act. It was a bipartisan effort to foster technological innovation and the technological competitiveness of the United States in the international arena. The first National Medals of Technology were issued in 1985 by then-U.S. President Ronald Reagan to 12 individuals and one company. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Sclerosis
Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, and trouble with sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In the relapsing forms of MS, between attacks, symptoms may disappear completely, although some permanent neurological problems often remain, especially as the disease advances. While the cause is unclear, the underlying mechanism is thought to be either destruction by the immune system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nutley, New Jersey
Nutley is a township in Essex County, New Jersey, United States. As of the 2020 United States census, the township's population was 30,143. What is now Nutley was originally incorporated as Franklin Township by an act of the New Jersey Legislature on February 18, 1874, from portions of Belleville Township. Nutley was incorporated as a town on March 5, 1902, replacing Franklin Township.Snyder, John P''The Story of New Jersey's Civil Boundaries: 1606–1968'' Bureau of Geology and Topography; Trenton, New Jersey; 1969. p. 130 for Nutley, p. 128 for Franklin Township. Accessed June 1, 2012. In 1981, the town was one of seven Essex County municipalities to pass a referendum to become a township, joining four municipalities that had already made the change, of what would ultimately be more than a dozen Essex County municipalities to reclassify themselves as townships in order take advantage of federal revenue sharing policies that allocated townships a greater share of government ai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reversed Phase HPLC
High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out of the column. HPLC has been used for manufacturing (''e.g.'', during the production process of pharmaceutical and biological products), legal (''e.g.'', detecting performance enhancement drugs in urine), research (''e.g.'', separating the components of a complex biological sample, or of similar synthetic chemicals from each other), and medical (''e.g.'', detecting vitamin D levels in blood serum) purposes. Chrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Biosynthesis
Protein biosynthesis (or protein synthesis) is a core biological process, occurring inside cells, balancing the loss of cellular proteins (via degradation or export) through the production of new proteins. Proteins perform a number of critical functions as enzymes, structural proteins or hormones. Protein synthesis is a very similar process for both prokaryotes and eukaryotes but there are some distinct differences. Protein synthesis can be divided broadly into two phases - transcription and translation. During transcription, a section of DNA encoding a protein, known as a gene, is converted into a template molecule called messenger RNA (mRNA). This conversion is carried out by enzymes, known as RNA polymerases, in the nucleus of the cell. In eukaryotes, this mRNA is initially produced in a premature form (pre-mRNA) which undergoes post-transcriptional modifications to produce mature mRNA. The mature mRNA is exported from the cell nucleus via nuclear pores to the cytoplasm of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosomal RNA
Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form SSU rRNA, small and LSU rRNA, large ribosome subunits. rRNA is the physical and mechanical factor of the ribosome that forces transfer RNA (tRNA) and messenger RNA (mRNA) to process and Translation (biology), translate the latter into proteins. Ribosomal RNA is the predominant form of RNA found in most cells; it makes up about 80% of cellular RNA despite never being translated into proteins itself. Ribosomes are composed of approximately 60% rRNA and 40% ribosomal proteins by mass. Structure Although the primary structure of rRNA sequences can vary across organisms, Base pair, base-pairing within these sequences commonly forms stem-loop configurations. The length and position of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall W
Marshall may refer to: Places Australia * Marshall, Victoria, a suburb of Geelong, Victoria Canada * Marshall, Saskatchewan * The Marshall, a mountain in British Columbia Liberia * Marshall, Liberia Marshall Islands * Marshall Islands, an island nation in the Pacific Ocean United States of America * Marshall, Alaska * Marshall, Arkansas * Marshall, California * Lotus, California, former name Marshall * Marshall Pass, a mountain pass in Colorado * Marshall, Illinois * Marshall, Indiana * Marshall, Michigan * Marshall, Minnesota * Marshall, Missouri * Marshall, New York * Marshall, North Carolina * Marshall, North Dakota * Marshall, Oklahoma * Marshall, Texas, the largest U.S. city named Marshall * Marshall, Virginia * Marshall, Wisconsin (other) ** Marshall, Dane County, Wisconsin ** Marshall, Richland County, Wisconsin ** Marshall, Rusk County, Wisconsin Businesses * Marshall of Cambridge, a British holding company encompassing aerospace, fleet management, propert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania School Of Medicine
The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medical school in the United States and is one of the seven Ivy League medical schools. Penn Med is consistently one of the top recipients of NIH research awards and is currently ranked sixth for research among American medical schools by '' U.S. News & World Report''. History The school of medicine was founded by Dr. John Morgan, a graduate of the College of Philadelphia (the precursor of the University of Pennsylvania) and the University of Edinburgh Medical School. After training in Edinburgh and other European cities, Dr. Morgan returned to Philadelphia in 1765. With fellow University of Edinburgh Medical School graduate Dr. William Shippen Jr., Morgan persuaded the college's trustees to found the first medical school in the Original ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall Warren Nirenberg
Marshall Warren Nirenberg (April 10, 1927 – January 15, 2010) was an American biochemist and geneticist. He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for "breaking the genetic code" and describing how it operates in protein synthesis. In the same year, together with Har Gobind Khorana, he was awarded the Louisa Gross Horwitz Prize from Columbia University. Biography Nirenberg was born in New York City to a Jewish family, the son of Minerva (Bykowsky) and Harry Edward Nirenberg, a shirtmaker. He developed rheumatic fever as a boy, so the family moved to Orlando, Florida to take advantage of the subtropical climate. He developed an early interest in biology. In 1948 he received his BS degree, and in 1952, a master's degree in zoology from the University of Florida at Gainesville where he was also a member of the Pi Lambda Phi Fraternity.Membership Directory, 2010, Pi Lambda Phi Inc. His dissertation for the Master's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
