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Shigeo Ohno
is a Japanese molecular biologist known for his pioneer research on Protein Kinase C (PKC) and Cell Polarity. His works led to the fundamental understanding of cell polarity in response to cell signaling. Contribution After the pivotal discovery of PKC by Yasutomi Nishizuka, in the mid 1980s, Ohno and his colleagues found novel PKC isotypes (nPKC) and atypical PKC isotypes (aPKC). These findings showed that PKC family plays various rules in cell signaling. On the other hand, the concept of cell polarity arises primarily through the localization of specific proteins to specific areas of the cell membrane. In 1988, Kenneth J. Kemphues and his colleagues identified par (partitioning defective) genes that are involved in cell-fate specification in ''Caenorhabditis elegans.'' In the mid 1990s, Kemphues research group cloned ''Par1'' and '' Par3'' genes in ''C. elegans,'' showing PAR1 is enriched at the posterior periphery in the cell while PAR3 is found at the anterior periphery. I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biologist
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Foundation For Cancer Research
The (JFCR) is a non-profit cancer research organization based in Ariake, Tokyo. The JFCR was founded in 1908 as the first Japanese organization specializing in cancer by Katsusaburō Yamagiwa and his supporters. The Cancer Institute and its attached hospital of JFCR were set up in 1934. The JFCR became a full member of the Union for International Cancer Control in 1968. Research The Cancer Institute of JFCR is one of the leading medical and biological research institutes in Japan. When the American journal ''Science'' published a special feature on science in Japan in 1992, the institute was described as one of the most productive and most cited institutions in the world at the time. The research at the Institute covers a wide variety of biomedical fields, including biochemistry, cell biology, pathology, carcinogenesis, genomics, system biology, and biomedical engineering. Achievements include the following. *1979: Tadatsugu Taniguchi isolated interferon gene. *1983: Mitsuaki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kobe, Japan
Kobe ( , ; officially , ) is the capital city of Hyōgo Prefecture Japan. With a population around 1.5 million, Kobe is Japan's seventh-largest city and the third-largest port city after Tokyo and Yokohama. It is located in Kansai region, which makes up the southern side of the main island of Honshū, on the north shore of Osaka Bay. It is part of the Keihanshin metropolitan area along with Osaka and Kyoto. The Kobe city centre is located about west of Osaka and southwest of Kyoto. The earliest written records regarding the region come from the '' Nihon Shoki'', which describes the founding of the Ikuta Shrine by Empress Jingū in AD 201.Ikuta Shrine official website – "History of Ikuta Shrine" (Japanese) [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by interfering with the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cells by natural selection in the body. Only certain mutations lead to cancer w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Growth
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism). Cell growth is not to be confused with cell division or the cell cycle, which are distinct processes that can occur alongside cell growth during the process of cell proliferation, where a cell, known as the mother cell, grows and divides to produce two daughter cells. Importantly, cell growth and cell division can also occur independently of one another. During early embryonic development ( cleavage of the zygote to form a morula and blastoderm), cell divisions occur repeatedly without cell growth. Conversely, some cells can grow without cell division or without any progression of the cell cycle, such as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
School Of Medicine
A medical school is a tertiary educational institution, or part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, Bachelor of Surgery (MBBS, MBChB, MBBCh, BMBS), Master of Medicine (MM, MMed), Doctor of Medicine (MD), or Doctor of Osteopathic Medicine (DO). Many medical schools offer additional degrees, such as a Doctor of Philosophy (PhD), master's degree (MSc) or other post-secondary education. Medical schools can also carry out medical research and operate teaching hospitals. Around the world, criteria, structure, teaching methodology, and nature of medical programs offered at medical schools vary considerably. Medical schools are often highly competitive, using standardized entrance examinations, as well as grade point averages and leadership roles, to narrow the selection criteria for candidates. In most countries, the study of medicine is completed as an undergraduate degr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yokohama City University
is a public university, in Yokohama, Kanagawa Prefecture, Japan. As of 2013, YCU has two faculties with a total of around 4,850 students, 111 of whom are foreign. YCU also has four campuses (Kanazawa-Hakkei, Fukuura, Maioka and Tsurumi) and two hospitals (YCU Hospital and YCU Medical Center). YCU is a member of the Port-City University League (PUL), and a core member of the Japanese University Network in the Bay Area (JUNBA). In 2017, YCU has been ranked #16th among "world's best small universities" in 2016-2017 (Times Higher Education), ranked at 23rd among life sciences institutes in Japan (Nature Index 2016). History From Yokohama School of Commerce to Yokohama City University The predecessor of YCU, the , was founded in 1882, initially maintained by an association of local merchants. In 1888, the school was renamed , a five-year school for boys (ages 14–19 or above). In 1917, Yokohama Commercial School was municipalized and in 1921 it became a seven-year commercial s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank Ruddle
Francis Hugh Ruddle (1929–2013) was an American cell and developmental biologist who was the Sterling Professor at Yale University. Ruddle was an early visionary of the Human Genome Project and created the first genetically modified mouse. He was a pioneer in both human and mouse genetics. Early life and education Ruddle's parents, Thomas H. Ruddle and Mary Henley Rhodda Ruddle, immigrated from the United Kingdom to West New York, New Jersey, where Frank was born on August 19, 1929. He grew up in Mariemont, Ohio, where Ruddle spent a lot of his childhood near the Ohio River. Leaving high school early, Frank became a member of the United States Air Force in 1946 and fought for the country up until the year 1949. With the help of the GI Bill, Frank was able to continue his education at Wayne State University, where he earned both his bachelor's degree and master's degree just two years apart. During the year of 1960, he received his Ph.D. in zoology at the University of Califor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
