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Schradan
Schradan, named after Gerhard Schrader, is an obsolete organophosphate insecticide. Schradan itself is a weak cholinesterase inhibitor and requires metabolic activation to become active. See also *Dimefox Dimefox was an organophosphate pesticide. In its pure form it is a colourless liquid with a fishy odour. Dimefox was first produced in 1940 by the group of Gerhard Schrader in Germany. It was historically used as a pesticide, but has been deeme ... * Mipafox References Acetylcholinesterase inhibitors Organophosphate insecticides {{Organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dimefox
Dimefox was an organophosphate pesticide. In its pure form it is a colourless liquid with a fishy odour. Dimefox was first produced in 1940 by the group of Gerhard Schrader in Germany. It was historically used as a pesticide, but has been deemed obsolete or discontinued for use by the World Health Organization It is not guaranteed that all commercial use of this compound ceased, but in most countries it is no longer registered for use as a pesticide.the WHO recommended classification of pesticides by hazard and guidelines to classification 2009/ref> It is considered an List of extremely hazardous substances, extremely hazardous substance as defined by the United States Emergency Planning and Community Right-to-Know Act. See also * Mipafox *Schradan Schradan, named after Gerhard Schrader, is an obsolete organophosphate insecticide. Schradan itself is a weak cholinesterase inhibitor and requires metabolic activation to become active. See also *Dimefox Dimefox was an organoph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mipafox
Mipafox is a highly toxic organophosphate insecticide that can cause delayed neurotoxicity and paralysis. It is an irreversible acetylcholinesterase inhibitor that is resistant to oxime reactivators. Synthesis Phosphoryl chloride is first reacted with isopropylamine. The resulting product is then reacted with potassium fluoride or ammonium fluoride to produce mipafox. See also *Dimefox *Schradan Schradan, named after Gerhard Schrader, is an obsolete organophosphate insecticide. Schradan itself is a weak cholinesterase inhibitor and requires metabolic activation to become active. See also *Dimefox Dimefox was an organophosphate pestic ... References Acetylcholinesterase inhibitors Organophosphate insecticides Fluorine compounds Isopropyl compounds {{Organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Schrader
Gerhard Schrader (25 February 1903 – 10 April 1990) was a German chemist specializing in the discovery of new insecticides, hoping to make progress in the fight against hunger in the world. Schrader is best known for his accidental discovery of nerve agents such as sarin and tabun, and for this he is sometimes called the "father of the nerve agents". Schrader was born in Bortfeld, near Wendeburg, Germany. He attended gymnasium in Braunschweig and later studied chemistry at Braunschweig University of Technology. He was later employed at the Bayer AG division of IG Farben. Schrader discovered several very effective insecticides, including bladan (the first fully synthetic contact insecticide Hexaethyl tetraphosphate being a constituent), and parathion (E 605). In 1936, while employed by the large German conglomerate IG Farben, he was experimenting with a class of compounds called organophosphates, which killed insects by interrupting their nervous systems. Instead of a new inse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organophosphate Insecticide
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product phy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Biochemical Journal
The ''Biochemical Journal'' is a peer-reviewed scientific journal which covers all aspects of biochemistry, as well as cell and molecular biology. It is published by Portland Press and was established in 1906. History The journal was established in 1906 by Benjamin Moore, holder of the first UK chair of biochemistry at the University of Liverpool, with financial support from Edward Whitley, an heir of the Greenall Whitley brewers.Clark J. Biochemical Journal Centenary (2006) (accessed 30 September 2007) The two served as the first and the journal was initially published by the |
Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
