Schilder's Disease (other)
Schilder's disease may refer to two different diseases described by Paul Schilder: * Adrenoleukodystrophy * Diffuse myelinoclastic sclerosis Diffuse myelinoclastic sclerosis, sometimes referred to as Schilder's disease, is a very infrequent neurodegenerative disease that presents clinically as pseudotumoural demyelinating lesions, making its diagnosis difficult. It usually begins in c ...

Paul Schilder
Paul Ferdinand Schilder (February 15, 1886, Vienna – December 7, 1940, New York City) was an Austrian psychiatrist, psychoanalyst, and medical researcher. Neurological research work (in both neurophysiology and neuropathology), coupled with an active interest in philosophy, led to involvement in psychoanalysis. He became a member of the Vienna Psychoanalytic Society founded by Sigmund Freud, although he never underwent analysis himself. He deviated from accepted psychoanalytic doctrine (especially regarding the existence of a death drive) and published his own ideas. He started the integration of psychoanalytic theory into psychiatry, and he is considered one of the founding fathers of group psychotherapy. He also introduced the concept of the body image, which has provided a lasting contribution to psychological and medical thinking. He was a prolific author on a range of subjects. As a biomedical researcher, he worked on the description of several conditions that were named af ...
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Adrenoleukodystrophy
Adrenoleukodystrophy (ALD) is a disease linked to the X chromosome. It is a result of fatty acid buildup caused by peroxisomal fatty acid beta oxidation which results in the accumulation of very long chain fatty acids in tissues throughout the body. The most severely affected tissues are the myelin in the central nervous system, the adrenal cortex, and the Leydig cells in the testes. The long chain fatty acid buildup causes damage to the myelin sheath of the neurons of the brain, resulting in seizures and hyperactivity. Other symptoms include problems in speaking, listening, and understanding verbal instructions. Clinically, ALD presents as a heterogeneous disorder, showing several distinct phenotypes, and no clear pattern of genotype–phenotype correlation. As an X-linked disorder, ALD presents most commonly in males; however, approximately 50% of heterozygote females show some symptoms later in life. Approximately two-thirds of ALD patients will present with the childhood ce ...
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