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Sceletium
Sceletium tortuosum is a succulent plant commonly found in South Africa, which is also known as Kanna, Channa, Kougoed (Kauwgoed/ 'kougoed', prepared from 'fermenting' ''S. tortuosum'')—which literally means, 'chew(able) things' or 'something to chew'. The generally recognised eight ''Sceletium'' species are ''S. crassicaule'', ''S. emarcidum'', ''S. exalatum'', ''S. expansum'', ''S. rigidum'', ''S. strictum'', ''S. tortuosum'' and ''S. varians''. Per Klak et al. (2007), an alternative classification for the ''Sceletium'' group is ''Mesembryanthemum crassicaule'', ''M. emarcidum'', ''M. exalatum'', ''M. expansum'', ''M. archeri'' (''S. rigidum''), ''M. ladismithiense'' (''S. strictum''), ''M. tortuosum'' and ''M. varians''. History The plant has been used by South African pastoralists and hunter-gatherers as a mood-altering substance from prehistoric times. The first known written account of the plant's use was in 1662 by Jan van Riebeeck. The traditionally prepared d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sceletium Tortuosum Commercial Sale
Sceletium tortuosum is a succulent plant commonly found in South Africa, which is also known as Kanna, Channa, Kougoed (Kauwgoed/ 'kougoed', prepared from 'fermenting' ''S. tortuosum'')—which literally means, 'chew(able) things' or 'something to chew'. The generally recognised eight ''Sceletium'' species are ''S. crassicaule'', ''S. emarcidum'', ''S. exalatum'', ''S. expansum'', ''S. rigidum'', ''S. strictum'', ''S. tortuosum'' and ''S. varians''. Per Klak et al. (2007), an alternative classification for the ''Sceletium'' group is ''Mesembryanthemum crassicaule'', ''M. emarcidum'', ''M. exalatum'', ''M. expansum'', ''M. archeri'' (''S. rigidum''), ''M. ladismithiense'' (''S. strictum''), ''M. tortuosum'' and ''M. varians''. History The plant has been used by South African pastoralists and hunter-gatherers as a mood-altering substance from prehistoric times. The first known written account of the plant's use was in 1662 by Jan van Riebeeck. The traditionally prepared d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sceletium
Sceletium tortuosum is a succulent plant commonly found in South Africa, which is also known as Kanna, Channa, Kougoed (Kauwgoed/ 'kougoed', prepared from 'fermenting' ''S. tortuosum'')—which literally means, 'chew(able) things' or 'something to chew'. The generally recognised eight ''Sceletium'' species are ''S. crassicaule'', ''S. emarcidum'', ''S. exalatum'', ''S. expansum'', ''S. rigidum'', ''S. strictum'', ''S. tortuosum'' and ''S. varians''. Per Klak et al. (2007), an alternative classification for the ''Sceletium'' group is ''Mesembryanthemum crassicaule'', ''M. emarcidum'', ''M. exalatum'', ''M. expansum'', ''M. archeri'' (''S. rigidum''), ''M. ladismithiense'' (''S. strictum''), ''M. tortuosum'' and ''M. varians''. History The plant has been used by South African pastoralists and hunter-gatherers as a mood-altering substance from prehistoric times. The first known written account of the plant's use was in 1662 by Jan van Riebeeck. The traditionally prepared d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesembrine
Mesembrine is an alkaloid present in ''Sceletium tortuosum'' (kanna). It has been shown to act as a serotonin reuptake inhibitor (Ki = 1.4 nM), and more recently, has also been found to behave as a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4) (Ki = 7,800 nM). Still more recently, in an in vitro study published in 2015, scientist concluded that "a high-mesembrine Sceletium extract exerts its anti-depressant effect by acting primarily as monoamine releasing agent, rather than as selective serotonin-reuptake inhibitor." As such, mesembrine likely plays a dominant role in the antidepressant effects of kanna. The levorotatory isomer, (−)-mesembrine, is the natural form. Rat studies have evaluated effects of kanna extract, finding analgesic and antidepressant potential. No adverse results were noted for a commercial extract up to 5000 mg/kg daily in rats. Mesembrine has also been identified in Mesembryanthemum cordifolium, Delosperma ech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesembrenone
Mesembrenone is an alkaloid constituent of ''Sceletium tortuosum'' (Kanna) and minor constituent of Lampranthus aureus and Lampranthus spectabilis Similar to modern synthetic antidepressants, it is a potent (IC50 < 1 μM) selective inhibitor of the (SERT) (that is, a ; Ki = 27 nM) and also a (PDE4) |
Tortuosamine
Tortuosamine is an alkaloid found in ''Sceletium tortuosum Sceletium tortuosum is a succulent plant commonly found in South Africa, which is also known as Kanna, Channa, Kougoed (Kauwgoed/ 'kougoed', prepared from 'fermenting' ''S. tortuosum'')—which literally means, 'chew(able) things' or 'something ...''. References * * {{alkaloid-stub Quinoline alkaloids Secondary amines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kanna Flower
Kanna may refer to: Plants *''Mesembryanthemum tortuosum'', syn. ''Sceletium tortuosum'', a Southern African succulent with psychoactive properties *''Platysace cirrosa'', a Western Australian perennial herb *''Caroxylon aphyllum'', a shrub Japan *Kanna (era), a Japanese name for the years 985–987 * Kanna or Japanese plane, a wood working tool Art and entertainment Film & TV * ''Kanna'' (film), a 2007 Indian movie * ''Kanna Laddu Thinna Aasaiya'', a 2013 Indian comedy * Kanna Kamui, a main character from the Japanese anime/manga Miss Kobayashi's Dragon Maid People *Kanna (given name), a feminine Japanese given name *Yonadam Kanna (born 1951), president of the Assyrian Democratic Movement and member of the Iraqi Parliament Places *Kanna (Lycaonia), ancient town now in Turkey *Kanna, Gunma, a town in Gunma Prefecture, Japan * Kanna, Poland, a village in southern Poland See also * Kannas (other) *Kana (other) Kana is a system of Japanese writing. Kana may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphodiesterase-4 Inhibitor
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of Phosphodiesterase inhibitor, PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly responsible for hydrolyzing cAMP within both immune cells and cells in the central nervous system. Therapeutic utility The prototypical PDE4 inhibitor is rolipram. PDE4 inhibitors are known to possess procognitive (including long term memory-improving), wakefulness-promoting, neuroprotective, and anti-inflammatory effects. Consequently, PDE4 inhibitors have been investigated as treatments for a diverse group of different diseases, including central nervous system disorders such as major depressive disorder (clinical depression), anxiety disorders, schizophrenia, Parkinson's disease, Alzheimer's disease, multiple scl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Succulent Plant
In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid climates or soil conditions. The word ''succulent'' comes from the Latin word ''sucus'', meaning "juice" or "sap". Succulent plants may store water in various structures, such as leaves and stems. The water content of some succulent organs can get up to 90–95%, such as ''Glottiphyllum semicyllindricum'' and ''Mesembryanthemum barkleyii''. Some definitions also include roots, thus geophytes that survive unfavorable periods by dying back to underground storage organs may be regarded as succulents. The habitats of these water-preserving plants are often in areas with high temperatures and low rainfall, such as deserts, but succulents may be found even in alpine ecosystems growing in rocky soil. Succulents are characterized by their ability to thrive on limited water sources, such as mist and dew, which makes them equipped t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aizoaceae
The Aizoaceae, or fig-marigold family, is a large family of dicotyledonous flowering plants containing 135 genera and about 1800 species. They are commonly known as ice plants or carpet weeds. They are often called vygies in South Africa and New Zealand. Highly succulent species that resemble stones are sometimes called mesembs. Description The family Aizoaceae is widely recognised by taxonomists. It once went by the botanical name "Ficoidaceae", now disallowed. The APG II system of 2003 (unchanged from the APG system of 1998) also recognizes the family, and assigns it to the order Caryophyllales in the clade core eudicots. The APG II system also classes the former families Mesembryanthemaceae Fenzl, Sesuviaceae Horan. and Tetragoniaceae Link under the family Aizoaceae. The common Afrikaans name "vygie" meaning "small fig" refers to the fruiting capsule, which resembles the true fig. Glistening epidermal bladder cells give the family its common name "ice plants". Most s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, ''in vitro'', a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microorganism. IC50 values are typically expressed as molar concentration. IC50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect ''in vivo''. IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. :\ce = -\log_ \ce Due to the minus sign, higher values of pIC50 in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning, and a greater cognitive decline than what is caused by normal aging. Several diseases and injuries to the brain, such as a stroke, can give rise to dementia. However, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychoactive Drug
A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. These substances may be used medically, recreationally or spiritually to a. Purposefully improve one’s perceived performance b. Alter one's consciousness (such as with entheogens for ritual, spiritual or shamanic purposes) or c. For research. Some categories of psychoactive drugs - which are believed, by some, to have therapeutic value - may be prescribed by some physicians and other healthcare practitioners. Examples of medication categories that may contain potentially beneficial psychoactive drugs include, but are not limited to: # Anesthetics # Analgesics # Anticonvulsants # Anti-Parkinson’s medications # Medications used to treat Neuropsychiatric Disorders a. Antidepressants b. Anxiolytics c. Antipsychotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
