Sarah A. Tishkoff
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Sarah A. Tishkoff
Sarah Anne Tishkoff (born December 26, 1965) is an American geneticist and the David and Lyn Silfen Professor in the Department of Genetics and Biology at the University of Pennsylvania. She also serves as a director for the American Society of Human Genetics and is an associate editor at PLOS Genetics, G3 (Genes, Genomes, and Genetics), and Genome Research. She is also a member of the scientific advisory board at the David and Lucile Packard Foundation. Tishkoff has been a leading figure in using genetics to advance understanding of modern human diversity. In particular she has made significant contributions to research on human genetic variation in African populations. In 1996, she and colleagues published the first paper to support the Out-of-Africa hypothesis using the nuclear genome, illustrating the extent of diversity among African populations. In 2001, Tishkoff and colleagues were some of the first to show the genomic signature of natural selection in human populations. ...
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Population Genetics
Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure. Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics. Traditionally a highly mathematical discipline, modern population genetics encompasses theoretical, laboratory, and field work. Population genetic models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population genetics apart from newer, more phenotypic approaches to modelling evolution, such as evolutionary game theory and adaptive dynamics, is its emphasis on such genetic phenomena as dominance, epi ...
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Natural Selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with selective breeding, artificial selection, which in his view is intentional, whereas natural selection is not. Genetic diversity, Variation exists within all populations of organisms. This occurs partly because random mutations arise in the genome of an individual organism, and their offspring can inherit such mutations. Throughout the lives of the individuals, their genomes interact with their environments to cause variations in traits. The environment of a genome includes the molecular biology in the Cell (biology), cell, other cells, other individuals, populations, species, as well as the abiotic environment. Because individuals with certain variants of the trait tend ...
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Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ...
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Allan Wilson (biologist)
Allan Charles Wilson FRS AAA&S (18 October 1934 – 21 July 1991) was a professor of biochemistry at the University of California, Berkeley, a pioneer in the use of molecular approaches to understand evolutionary change and reconstruct phylogenies, and a revolutionary contributor to the study of human evolution. He was one of the most controversial figures in post-war biology; his work attracted a great deal of attention both from within and outside the academic world. He is the only New Zealander to have won the MacArthur Fellowship. He is best known for experimental demonstration of the concept of the molecular clock (with his doctoral student Vincent Sarich), which was theoretically postulated by Linus Pauling and Emile Zuckerkandl, revolutionary insights into the nature of the molecular anthropology of higher primates and human evolution, and the so-called Mitochondrial Eve hypothesis (with his doctoral students Rebecca L. Cann and Mark Stoneking). Early life and educatio ...
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Cultural Anthropology
Cultural anthropology is a branch of anthropology focused on the study of cultural variation among humans. It is in contrast to social anthropology, which perceives cultural variation as a subset of a posited anthropological constant. The portmanteau term sociocultural anthropology includes both cultural and social anthropology traditions. Anthropologists have pointed out that through culture people can adapt to their environment in non-genetic ways, so people living in different environments will often have different cultures. Much of anthropological theory has originated in an appreciation of and interest in the tension between the local (particular cultures) and the global (a universal human nature, or the web of connections between people in distinct places/circumstances). Cultural anthropology has a rich methodology, including participant observation (often called fieldwork because it requires the anthropologist spending an extended period of time at the research locat ...
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Margaret Mead
Margaret Mead (December 16, 1901 – November 15, 1978) was an American cultural anthropologist who featured frequently as an author and speaker in the mass media during the 1960s and the 1970s. She earned her bachelor's degree at Barnard College of Columbia University and her M.A. and Ph.D. degrees from Columbia. Mead served as president of the American Association for the Advancement of Science in 1975. Mead was a communicator of anthropology in modern American and Western culture and was often controversial as an academic. Her reports detailing the attitudes towards sex in South Pacific and Southeast Asian traditional cultures influenced the 1960s sexual revolution. She was a proponent of broadening sexual conventions within the context of Western cultural traditions. Birth, early family life, and education Margaret Mead, the first of five children, was born in Philadelphia but raised in nearby Doylestown, Pennsylvania. Her father, Edward Sherwood Mead, was a professor of ...
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Coming Of Age In Samoa
''Coming of Age in Samoa: A Psychological Study of Primitive Youth for Western Civilisation'' is a 1928 book by American Anthropology, anthropologist Margaret Mead based upon her research and study of youth – primarily adolescent girls – on the island of Taʻū in the Samoan Islands. The book details the sexual life of teenagers in Samoan society in the early 20th century, and theorizes that culture has a leading influence on psychosexual development. First published in 1928, the book launched Mead as a pioneering researcher and as the most famous anthropologist in the world. Since its first publication, ''Coming of Age in Samoa'' was the most widely read book in the field of anthropology until Napoleon Chagnon's ''Yanomamö: The Fierce People'' overtook it. The book has sparked years of ongoing and intense debate and controversy on questions pertaining to society, culture, and science. It is a key text in the nature versus nurture debate, as well as in discussions on issues ...
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Oregon Institute Of Technology
The Oregon Institute of Technology (Oregon Tech) is a public polytechnic university in Oregon with a residential campus in Klamath Falls, Oregon, an urban campus in Wilsonville, Oregon, and additional locations in Salem and Seattle. Oregon Tech provides 32 degree programs in engineering, health technologies, management, communication, psychology, and applied sciences with a total of 37 majors. Almost all students complete externships, co-ops, or other hands-on training inside and outside the classroom. History Oregon Tech was founded as the Oregon Vocational School on July 15, 1947, to train and re-educate returning World War II veterans. Under the direction of Winston Purvine, the first classes were held in a deactivated Marine Corps hospital three miles northeast of Klamath Falls. The following year, the school's title was changed to the Oregon Technical Institute. In the first school year, 1947-1948, veterans constituted 98 percent of student enrollment. By 1950, the figure ...
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University Of California, Los Angeles
The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California State Normal School (now San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to university in the United States. The university is organized into the College of Letters and Science and 12 professional schools. Six of the schools offer undergraduate degre ...
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Klamath Falls, Oregon
Klamath Falls ( ) is a city in and the county seat of Klamath County, Oregon, United States. The city was originally called ''Linkville'' when George Nurse founded the town in 1867. It was named after the Link River, on whose falls the city was sited. The name was changed to Klamath Falls in 1893. The population was 21,813 at the 2020 census. The city is on the southeastern shore of the Upper Klamath Lake located about northwest of Reno, Nevada, and approximately north of the California–Oregon border. Logging was Klamath Falls's first major industry. Etymology At its founding in 1867, Klamath Falls was named Linkville. The name was changed to Klamath Falls in 1892–93. The name ''Klamath'' , may be a variation of the descriptive native for "people" Chinookan] used by the indigenous peoples of the Northwest Plateau to refer to the region. Several locatives derived from the Modoc or Achomawi: ''lutuami'', lit: "lake dwellers", ''móatakni'', "tule lake dwellers", respective ...
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East Lansing, Michigan
East Lansing is a city in the U.S. state of Michigan. Most of the city lies within Ingham County, Michigan, Ingham County with a smaller portion extending north into Clinton County, Michigan, Clinton County. At the 2020 United States Census, 2020 Census the population was 47,741. Located directly east of the state capital of Lansing, Michigan, Lansing, East Lansing is well-known as the home of Michigan State University. The city is part of the Lansing–East Lansing metropolitan area. History East Lansing is located on land that was an important junction of two major Native Americans in the United States, Native American groups: the Potawatomi and the Fox. By 1850, the Lansing and Howell Plank Road Company was established to connect a toll road to the Detroit and Howell Plank Road, improving travel between Detroit and Lansing, which cut right through what is now East Lansing. The toll road was finished in 1853, and included seven toll houses between Lansing and Howell, Michigan, Ho ...
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National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ...
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