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Sam Gandy
Samuel E. Gandy, is a neurologist, cell biologist, Alzheimer's disease (AD) researcher and expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. His team discovered the first drugs that could lower the formation of amyloid. As of 2020, he is Mount Sinai Professor of Alzheimer's Disease Research, professor of neurology and psychiatry, Icahn School of Medicine at Mount Sinai, director, Center for Cognitive Health and NFL Neurological Center Mount Sinai Hospital, visiting principal research fellow, South Australia Health and Medical Research Institute in Adelaide, SA, Australia, and chairman emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. He was also founding director, Farber Institute for the Neurosciences. Research Gandy has written more than 250 peer-reviewed papers, chapters and reviews on this topic. He has received continuous National Institutes of Health (NIH) fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charleston Southern University
Charleston Southern University (CSU) is a private Baptist university in North Charleston, South Carolina. It is affiliated with the South Carolina Baptist Convention ( Southern Baptist Convention). History Charleston Southern University was chartered in 1960 and became the Baptist College of Charleston, where it offered its first classes in the education building of the First Baptist Church of North Charleston. The university offered the first instruction at a post secondary level in 1965 and awarded its first degree in 1967. In 1990, the South Carolina Baptist Convention voted to change the university's name from Baptist College at Charleston to Charleston Southern University. Academics The university is accredited by the Commission on Colleges of the Southern Association of Colleges and Schools to award bachelor's and master's degrees. CSU students can choose from more than 50 undergraduate majors and graduate programs such as business, education, criminal justice, computer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Biological Chemistry
The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. As of January 2021, the journal is fully open access. In press articles are available free on its website immediately after acceptance. Editors The following individuals have served as editors of the journal: * 1906–1909: John Jacob Abel and Christian Archibald Herter * 1909–1910: Christian Archibald Herter * 1910–1914: Alfred Newton Richards * 1914–1925: Donald D. Van Slyke * 1925–1936: Stanley R. Benedict. After Benedict died, John T. Edsall served as temporary editor until the next editor was appointed. * 1937–1958: Rudolph J. Anderson * 1958–1967: John T. Edsall * 1968–1971: William Howard Stein * 1971–2011: Herbert Tabor * 2011–2015: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Neuroinflammation
The ''Journal of Neuroinflammation'' is a peer-reviewed open-access scientific journal covering immunological responses of the nervous system. It was established in 2004 and is published by BioMed Central. The editors-in-chief are Sue T. Griffin (University of Arkansas for Medical Sciences) and Monica J. Carson (University of California, Riverside), who succeeded Robert E. Mrak (University of Toledo Medical Center) in 2018. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 9.3. References External links * Neuroscience journals BioMed Central academic journals Academic journals established in 2004 Creative Commons A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karger Publishers
Karger Publishers (also: Karger Medical and Scientific Publishers, S. Karger AG) is an academic publisher of scientific and medical journals and books. The current CEO is Daniel Ebneter. History The company was founded in 1890 in Berlin by Samuel Karger, who remained at the helm of the company until his death in 1935. His son, Heinz Karger led the company until his death in 1959, and Heinz's son (and Samuel's grandson) Thomas Karger took over the leadership of the company; he was followed as the company leader by his eldest son, Steven Karger, and, most recently, by his youngest daughter, Gabriella Karger, who leads the publishing house now. Its first medical journal, '' Dermatologische Zeitschrift'' (later: ''Dermatologica'', now: ''Dermatology'') was established in 1893. The company published works from well-known scientists such as Sigmund Freud. Because of political pressure from the Nazi regime, the company was relocated to Basel, Switzerland, in 1937 and lost all German au ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organoid
An organoid is a miniaturized and simplified version of an Organ (anatomy), organ produced in vitro in three dimensions that shows realistic micro-anatomy. They are derived from one or a few Cell (biology), cells from a Tissue (biology), tissue, embryonic stem cells or induced pluripotent stem cells, which can Self-organization, self-organize in three-dimensional culture owing to their Stem cell, self-renewal and Cellular differentiation, differentiation capacities. The technique for growing organoids has rapidly improved since the early 2010s, and it was named by ''The Scientist (magazine), The Scientist'' as one of the biggest scientific advancements of 2013. Organoids are used by scientists to study disease and treatments in a laboratory. History Attempts to create organ (biology), organs ''in vitro'' started with one of the first dissociation-reaggregation experiments where Henry Van Peters Wilson demonstrated that mechanically dissociated sponge cells can reaggregate and se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Phosphorylation
Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become either activated or deactivated, or otherwise modifying its function. Approximately 13000 human proteins have sites that are phosphorylated. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most commonly phosphorylated are serine, threonine, tyrosine in eukaryotes, and also histidine in prokaryotes and plants (though it is now known to be common in humans). These phosphorylations play important and well-characterized roles in signaling pathways and metabolism. However, other amino acids can also be phosphory ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Veteran
A veteran () is a person who has significant experience (and is usually adept and esteemed) and expertise in a particular occupation or field. A military veteran is a person who is no longer serving in a military. A military veteran that has served directly in combat in a war is further defined as a war veteran (although not all military conflicts, or areas in which armed combat took place, are necessarily referred to as ''wars''). Military veterans are unique as a group as their lived experience is so strongly connected to the conduct of war in general and application of professional violence in particular. Therefore, there are a large body of knowledge developed through centuries of scholarly studies that seek to describe, understand and explain their lived experience in and out of service. Griffith with colleagues provides an overview of this research field that addresses veterans general health, transition from military service to civilian life, homelessness, veteran empl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repeated trauma to the head. The encephalopathy symptoms can include behavioral problems, mood problems, and problems with thinking. The disease often gets worse over time and can result in dementia. It is unclear if the risk of suicide is altered. Most documented cases have occurred in athletes involved in striking-based combat sports, such as boxing, kickboxing, mixed martial arts, and Muay Thai—hence its original name ''dementia pugilistica'' (Latin for "fistfighter's dementia")—and contact sports such as American football, Australian rules football, professional wrestling, ice hockey, rugby, and association football (soccer), in semi-contact sports such as baseball and basketball, and military combat arms occupations. Other risk factors include being in the military, prior domestic violence, and repeated banging of the head. The exact amount of trauma required for the condition to occur i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Encephalitis
Encephalitis is inflammation of the brain. The severity can be variable with symptoms including reduction or alteration in consciousness, headache, fever, confusion, a stiff neck, and vomiting. Complications may include seizures, hallucinations, trouble speaking, memory problems, and problems with hearing. Causes of encephalitis include viruses such as herpes simplex virus and rabies virus as well as bacteria, fungi, or parasites. Other causes include autoimmune diseases and certain medications. In many cases the cause remains unknown. Risk factors include a weak immune system. Diagnosis is typically based on symptoms and supported by blood tests, medical imaging, and analysis of cerebrospinal fluid. Certain types are preventable with vaccines. Treatment may include antiviral medications (such as acyclovir), anticonvulsants, and corticosteroids. Treatment generally takes place in hospital. Some people require artificial respiration. Once the immediate problem is under co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Head Injury
A head injury is any injury that results in trauma to the skull or brain. The terms ''traumatic brain injury'' and ''head injury'' are often used interchangeably in the medical literature. Because head injuries cover such a broad scope of injuries, there are many causes—including accidents, falls, physical assault, or traffic accidents—that can cause head injuries. The number of new cases is 1.7 million in the United States each year, with about 3% of these incidents leading to death. Adults have head injuries more frequently than any age group resulting from falls, motor vehicle crashes, colliding or being struck by an object, or assaults. Children, however, may experience head injuries from accidental falls or intentional causes (such as being struck or shaken) leading to hospitalization. Acquired brain injury (ABI) is a term used to differentiate brain injuries occurring after birth from injury, from a genetic disorder, or from a congenital disorder. Unlike a broken bon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
