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SUN Domain
SUN (Sad1p, UNC-84) domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton which enables mechanosensory roles in cells. SUN proteins are thought to localize to the inner nuclear membrane. The S. pombe Sad1 protein localises at the spindle pole body. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm. Examples of SUN Proteins ''Caenorhabditis elegans'' *SUN-1/matefin *UNC-84 ''Drosophila melanogaster'' *Klaroid *Spag4 Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. In general, domains vary in length from between about 50 amino acids up to 250 amino acids in length. The shortest domains, such as zinc fingers, are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be "swapped" by genetic engineering between one protein and another to make chimeric proteins. Background The concept of the domain was first proposed in 1973 by Wetlaufer aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUN5
SUN domain-containing protein 5, formerly known as sperm-associated antigen 4-like protein (SPAGL4), is a protein that in humans is encoded by the ''SUN5'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References Further reading * * * * * * {{gene-20-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUN4
Sun-4 is a series of Unix workstations and servers produced by Sun Microsystems, launched in 1987. The original Sun-4 series were VMEbus-based systems similar to the earlier Sun-3 series, but employing microprocessors based on Sun's own SPARC V7 RISC architecture in place of the 68k family processors of previous Sun models. Sun 4/280 was known as base system that was used for building of first RAID prototype. Models Models are listed in approximately chronological order. : In 1989, Sun dropped the "Sun-4" name for marketing purposes in favor of the SPARCstation and SPARCserver brands for new models, although early SPARCstation/server models were also assigned Sun-4-series model numbers. For example, the SPARCstation 1 was also known as the Sun 4/60. This practice was phased out with the introduction of the SPARCserver 600MP series in 1991. The term ''Sun-4'' continued to be used in an engineering context to identify the basic hardware architecture of all SPARC-based Sun system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUN3
Sun-3 is a series of UNIX computer workstations and servers produced by Sun Microsystems, launched on September 9, 1985. The Sun-3 series are VMEbus-based systems similar to some of the earlier Sun-2 series, but using the Motorola 68020 microprocessor, in combination with the Motorola 68881 floating-point co-processor (optional on the Sun 3/50) and a proprietary Sun MMU. Sun-3 systems were supported in SunOS versions 3.0 to 4.1.1_U1 and also have current support in NetBSD and Linux. Sun-3 models Models are listed in approximately chronological order. : (Max. RAM sizes may be greater when third-party memory boards are used.) Image:Sun3_CPU.jpg, Original Sun-3 CPU board Image:Sun3_4MbMemory_Sun3_Scsi.jpg, Original Sun-3 4 MB memory board with Sun-3 SCSI daughter board Image:Sun3_50CPUwHelios4Mb.jpg, Sun 3/50 CPU board with Helios 4 MB memory expansion Keyboard The Sun Type 3 keyboard is split into three blocks: * special keys * main block * numeric pad It shipped with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUN2
The Sun is the star at the center of the Solar System. It is a nearly perfect ball (mathematics), ball of hot plasma (physics), plasma, heated to incandescence by nuclear fusion reactions in its core. The Sun radiates this energy mainly as light, ultraviolet, and infrared radiation, and is the most important source of energy for life on Earth. solar radius, The Sun's radius is about , or 109 times that of Earth. solar mass, Its mass is about 330,000 times that of Earth, comprising about 99.86% of the total mass of the Solar System. Roughly three-quarters of the Sun's mass consists of hydrogen (~73%); the rest is mostly helium (~25%), with much smaller quantities of heavier elements, including oxygen, carbon, neon, and iron. The Sun is a G-type main-sequence star (G2V). As such, it is informally, and not completely accurately, referred to as a G-type main-sequence star, yellow dwarf (its light is actually white). It formed approximately 4.6 billionAll numbers in this ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUN1
Sun-1 was the first generation of UNIX computer workstations and servers produced by Sun Microsystems, launched in May 1982. These were based on a CPU board designed by Andy Bechtolsheim while he was a graduate student at Stanford University and funded by DARPA. The Sun-1 systems ran SunOS 0.9, a port of UniSoft's UniPlus V7 port of Seventh Edition UNIX to the Motorola 68000 microprocessor, with no window system. Early Sun-1 workstations and servers used the original Sun logo, a series of red "U"s laid out in a square, rather than the more familiar purple diamond shape used later. The first Sun-1 workstation was sold to Solo Systems in May 1982. The Sun-1/100 was used in the original Lucasfilm EditDroid non-linear editing system. Models Hardware The Sun-1 workstation was based on the Stanford University SUN workstation designed by Andy Bechtolsheim (advised by Vaughan Pratt and Forest Baskett), a graduate student and co-founder of Sun Microsystems. At the heart ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, five Nobel Prizes have been awarded to drosophilists for their work using the insect. ''D. melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. It was originally an African species, with all non-African lineages having a common origin. Its geographic range includes all continents, including islands. ''D. melanogaster'' is a common pest in homes, restaurants, and othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC84A
Protein unc-84 homolog A is a protein that in humans is encoded by the ''UNC84A'' gene. This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membrane ... protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined. References Further reading * * * * * * * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitotic Spindle
In cell biology, the spindle apparatus refers to the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell. Besides chromosomes, the spindle apparatus is composed of hundreds of proteins. Microtubules comprise the most abundant components of the machinery. Spindle structure Attachment of microtubules to chromosomes is mediated by kinetochores, which actively monitor spindle formation and prevent premature anaphase onset. Microtubule polymerization and depolymerization dynamic drive chromosome congression. Depolymerization of microtubules generates tension at kinetochores; bipolar attachment of sister kinetochores to microtubules emanating from opposite cell pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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