|
SNX12
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex. Function This gene encodes a member of the sorting nexin family. Members of this family contain a phox ( PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can ... protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. References Further reading * * * * * * * * * * * * * * * * * * * Exte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sorting Nexin
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting. Family members In humans, sorting nexins are transcribed from the following genes: Structure Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains. A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.) An example of a sorting nexin domain structure can be seen here for SNX1: # NTD – N-terminal domain # PX doma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |