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S100 Calcium-binding Protein A1
Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the ''S100A1'' gene. S100A1 is highly expressed in cardiac muscle, cardiac and skeletal muscle, and localizes to sarcomere, Z-discs and sarcoplasmic reticulum. S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardial infarction, myocardially infarcted cardiac tissue. Structure S100A1 is a member of the S-100 protein, S100 family of proteins expressed in cardiac muscle, skeletal muscle and brain, with highest density at sarcomere, Z-lines and sarcoplasmic reticulum. S100A1 contains 4 EF-hand calcium-binding structural motif, motifs in its dimerized form, and can exist as either a hetero or homoprotein dimer, dimer. The S100A1 homodimer is high affinity (nanomolar range or tighter), and is formed through hydrophobic packing of an X-type 4-helix bundle created between helices 1, 1', 4, and 4'. Protein nuclear magnetic resonance spectroscopy s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
