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Stephen P. O'Rahilly
Sir Stephen Patrick O'Rahilly (born 1 April 1958) is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders. Education O'Rahilly was born in Dublin, IrelandEllen Ruppel ShellFat Genes Discover Magazine, 1 May 2000 and educated at Beneavin College. He attended University College Dublin to study medicine. Research O'Rahilly undertook research into Type 2 diabetes and insulin resistance at the University of Oxford and Harvard Medical School, before joining the University of Cambridge where he is a Professor of Clinical Biochemistry and Medicine, Director of the Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Director of the MRC Metabolic Diseases Unit and co-director of the Wellcome-MRC Institute of Metabolic Science. He is also the scientific Director of the National Institute for Health and Care Research (NIHR) Cambridge Bio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Of Obesity
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. Polymorphisms in various genes controlling appetite and metabolism predispose to obesity under certain dietary conditions. The percentage of obesity that can be attributed to genetics varies widely, depending on the population examined, from 6% to 85%, with the typical estimate at 50%. It is likely that in each person a number of genes contribute to the likelihood of developing obesity in small part, with each gene increasing or decreasing the odds marginally, and together determining how an individual responds to the environmental factors. As of 2006, more than 41 sites on the human genome have been linked to the development of obesity when a favorable environment is present. Some o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Of Medical Sciences
The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to advance biomedical and health research and its translation into benefits for society. The academy consists of a group of around 1200 Fellows elected from fields across the biomedical sciences. The academy seeks ultimately to advance medical science and improve health by investing in talented researchers, engaging people on health-related issues and providing expert impartial advice. its president is Dame Anne Johnson. History The academy was established in 1998 following the recommendations of a working group chaired by Michael Atiyah, former president of the Royal Society. A single national organisation was formed to support biomedical scientists and clinical academics working together to promote advances in medical science. It is one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discover Magazine
''Discover'' is an American general audience science magazine launched in October 1980 by Time Inc. It has been owned by Kalmbach Publishing since 2010. History Founding ''Discover'' was created primarily through the efforts of ''Time'' magazine editor Leon Jaroff. He noticed that magazine sales jumped every time the cover featured a science topic. Jaroff interpreted this as a considerable public interest in science, and in 1971, he began agitating for the creation of a science-oriented magazine. This was difficult, as a former colleague noted, because "Selling science to people who graduated to be managers was very difficult".Hevesi, Dennis"Leon Jaroff, Editor at Time and Discover Magazines, Dies at 85" ''The New York Times'', 21 October 2012 Jaroff's persistence finally paid off, and ''Discover'' magazine published its first edition in 1980. ''Discover'' was originally launched into a burgeoning market for science magazines aimed at educated non-professionals, intended to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dublin
Dublin (; , or ) is the capital and largest city of Republic of Ireland, Ireland. On a bay at the mouth of the River Liffey, it is in the Provinces of Ireland, province of Leinster, bordered on the south by the Dublin Mountains, a part of the Wicklow Mountains range. At the 2016 census of Ireland, 2016 census it had a population of 1,173,179, while the preliminary results of the 2022 census of Ireland, 2022 census recorded that County Dublin as a whole had a population of 1,450,701, and that the population of the Greater Dublin Area was over 2 million, or roughly 40% of the Republic of Ireland's total population. A settlement was established in the area by the Gaels during or before the 7th century, followed by the Vikings. As the Kings of Dublin, Kingdom of Dublin grew, it became Ireland's principal settlement by the 12th century Anglo-Norman invasion of Ireland. The city expanded rapidly from the 17th century and was briefly the second largest in the British Empire and sixt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. History In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' purchased the weekly ''Intelligencer'' for $600 in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endocrine
The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems. In humans, the major endocrine glands are the thyroid gland and the adrenal glands. The study of the endocrine system and its disorders is known as endocrinology. Glands that signal each other in sequence are often referred to as an axis, such as the hypothalamic-pituitary-adrenal axis. In addition to the specialized endocrine organs mentioned above, many other organs that are part of other body systems have secondary endocrine functions, including bone, kidneys, liver, heart and gonads. For example, the kidney secretes the endocrine hormone erythropoietin. Hormones can be amino acid complexes, steroids, eicosanoids, leukotrienes, or prostaglandins. The endocrine system can be contrasted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin Resistance
Insulin resistance (IR) is a pathological condition in which cell (biology), cells fail to respond normally to the hormone insulin. Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). Insulin is released by the pancreas in response to carbohydrates consumed in the diet. In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. There are many causes of insulin resistance and the underlying process is still not completely understood, but sulfate depletion may be the important factor. Risk factors for insulin resistance include obesity, sedentary lifestyle, family history of diabetes, various health conditions, and certain medications. Insulin resistance is considered a component of the metabolic syndrome. There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's weight divided by the square of the person's height—is over ; the range is defined as overweight. Some East Asian countries use lower values to calculate obesity. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity has individual, socioeconomic, and environmental causes. Some known causes are diet, physical activity, automation, urbanization, genetic susceptibility, medications, mental disorders, economic policies, endocrine disorders, and exposure to endocrine-disrupting chemicals. While a majority of obese individuals at any given time are attempting to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathogenesis
Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pathos'' 'suffering, disease' and γένεσις ''genesis'' 'creation'. Description Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example, bacterial pathogenesis is the process by which bacteria cause infectious illness. Most diseases are caused by multiple processes. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression), Streptococcus pneumoniae is spread through contact with respiratory secretions, such as saliva, mucus, or cough droplets from an infected person and colonizes the upper respiratory tract and begins to multiply. The pathogenic mechanisms of a disease (or cond ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Honorary Fellow Of The Learned Society Of Wales
The Learned Society of Wales (Welsh: Cymdeithas Ddysgedig Cymru) is a learned society and charity that exists to "celebrate, recognise, preserve, protect and encourage excellence in all of the scholarly disciplines", and to serve the Welsh nation. The Learned Society of Wales is Wales's first and only all-embracing national scholarly academy. A registered charity, it was established and launched on 25 May 2010 at the National Museum of Wales and was granted a Royal Charter in 2015. The society is based in Cardiff. It is an independent, self-governing, pan-disciplinary, bilingual organisation operating throughout Wales. Purpose The Society describes its mission as to: * Celebrate, recognise, preserve, protect, and encourage excellence in all scholarly disciplines, and in the professions, industry and commerce, the arts and public service. * Promote the advancement of learning, scholarship, and the dissemination and application of the results of academic enquiry and research. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Irish Academy
The Royal Irish Academy (RIA; ga, Acadamh Ríoga na hÉireann), based in Dublin, is an academic body that promotes study in the sciences, humanities and social sciences. It is Ireland's premier List of Irish learned societies, learned society and one its leading List of Irish cultural institutions, cultural institutions. The Academy was established in 1785 and granted a royal charter in 1786. the RIA has around 600 members, regular members being Irish residents elected in recognition of their academic achievements, and Honorary Members similarly qualified but based abroad; a small number of members are elected in recognition of non-academic contributions to society. Until the late 19th century the Royal Irish Academy was the owner of the main national collection of Irish antiquities. It presented its collection of archaeological artefacts and similar items, which included such famous pieces as the Tara Brooch, the Cross of Cong and the Ardagh Chalice to what is now the Na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knight Bachelor
The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are the most ancient sort of British knight (the rank existed during the 13th-century reign of King Henry III), but Knights Bachelor rank below knights of chivalric orders. A man who is knighted is formally addressed as "Sir irst Name urname or "Sir irst Name and his wife as "Lady urname. Criteria Knighthood is usually conferred for public service; amongst its recipients are all male judges of His Majesty's High Court of Justice in England. It is possible to be a Knight Bachelor and a junior member of an order of chivalry without being a knight of that order; this situation has become rather common, especially among those recognized for achievements in entertainment. For instance, Sir Michael Gambon, Sir Derek Jacobi, Sir Anthony Hopkins, Sir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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