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Sholl Analysis
Sholl analysis is a method of quantitative analysis commonly used in neuronal studies to characterize the morphological characteristics of an imaged neuron, first used to describe the differences in the visual and motor cortices of cats in the early 1950s.Sholl, D.A., 1953. Dendritic organization in the neurons of the visual and motor cortices of the cat. J. Anat. 87, 387–406 Sholl was interested in comparing the morphology of different types of neurons, such as the star-shaped stellate cells and the cone-shaped pyramidal cells, and of different locations in the dendritic field of the same type of neurons, such as basal and apical processes of the pyramidal neuron. He looked at dendritic length and diameter (Sholl, p. 389, Fig. 1) and also the number of cells per volume (Sholl, p. 401, ''The packing density of perikarya''). While methods for estimating the number of cells have vastly improved since 1953 with the advent of unbiased stereology, the method Sholl used to r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantitative Research
Quantitative research is a research strategy that focuses on quantifying the collection and analysis of data. It is formed from a deductive approach where emphasis is placed on the testing of theory, shaped by empiricist and positivist philosophies. Associated with the natural, applied, formal, and social sciences this research strategy promotes the objective empirical investigation of observable phenomena to test and understand relationships. This is done through a range of quantifying methods and techniques, reflecting on its broad utilization as a research strategy across differing academic disciplines. The objective of quantitative research is to develop and employ mathematical models, theories, and hypotheses pertaining to phenomena. The process of measurement is central to quantitative research because it provides the fundamental connection between empirical observation and mathematical expression of quantitative relationships. Quantitative data is any data that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Logarithm
In mathematics, the logarithm is the inverse function to exponentiation. That means the logarithm of a number to the base is the exponent to which must be raised, to produce . For example, since , the ''logarithm base'' 10 of is , or . The logarithm of to ''base'' is denoted as , or without parentheses, , or even without the explicit base, , when no confusion is possible, or when the base does not matter such as in big O notation. The logarithm base is called the decimal or common logarithm and is commonly used in science and engineering. The natural logarithm has the number e (mathematical constant), as its base; its use is widespread in mathematics and physics, because of its very simple derivative. The binary logarithm uses base and is frequently used in computer science. Logarithms were introduced by John Napier in 1614 as a means of simplifying calculations. They were rapidly adopted by navigators, scientists, engineers, surveyors and oth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fiji (software)
Fiji (''Fiji Is Just ImageJ'') is an open source image processing package based on ImageJ2. Fiji's main purpose is to provide a distribution of ImageJ2 with many bundled plugins. Fiji features an integrated updating system and aims to provide users with a coherent menu structure, extensive documentation in the form of detailed algorithm descriptions and tutorials, and the ability to avoid the need to install multiple components from different sources. Fiji is also targeted at developers, through the use of a version control system, an issue tracker, dedicated development channels, and a rapid-prototyping infrastructure in the form of a script editor which supports BeanShell, Jython, JRuby, Clojure, Groovy, JavaScript, and other scripting languages, as well as just-in-time Java development. Plugins Many plugins exist for ImageJ, that have a wide range of applications, but also a wide range of quality. Further, some plugins require specific versions of ImageJ, specific version ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Open-source Software
Open-source software (OSS) is computer software that is released under a license in which the copyright holder grants users the rights to use, study, change, and distribute the software and its source code to anyone and for any purpose. Open-source software may be developed in a collaborative public manner. Open-source software is a prominent example of open collaboration, meaning any capable user is able to participate online in development, making the number of possible contributors indefinite. The ability to examine the code facilitates public trust in the software. Open-source software development can bring in diverse perspectives beyond those of a single company. A 2008 report by the Standish Group stated that adoption of open-source software models has resulted in savings of about $60 billion per year for consumers. Open source code can be used for studying and allows capable end users to adapt software to their personal needs in a similar way user scripts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuronal Tracing
Neuronal tracing, or neuron reconstruction is a technique used in neuroscience to determine the pathway of the neurites or neuronal processes, the axons and dendrites, of a neuron. From a sample preparation point of view, it may refer to some of the following as well as other genetic neuron labeling techniques, * Anterograde tracing, for labeling from the cell body to synapse; * Retrograde tracing, for labeling from the synapse to cell body; * Viral neuronal tracing, for a technique which can be used to label in either direction; * Manual tracing of neuronal imagery. In broad sense, neuron tracing is more often related to digital reconstruction of a neuron's morphology from imaging data of above samples. Digital neuronal reconstruction and neuronal tracing Digital reconstruction or tracing of neuron morphology is a fundamental task in computational neuroscience. It is also critical for mapping neuronal circuits based on advanced microscope images, usually based on light microsc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sholl Analysis
Sholl analysis is a method of quantitative analysis commonly used in neuronal studies to characterize the morphological characteristics of an imaged neuron, first used to describe the differences in the visual and motor cortices of cats in the early 1950s.Sholl, D.A., 1953. Dendritic organization in the neurons of the visual and motor cortices of the cat. J. Anat. 87, 387–406 Sholl was interested in comparing the morphology of different types of neurons, such as the star-shaped stellate cells and the cone-shaped pyramidal cells, and of different locations in the dendritic field of the same type of neurons, such as basal and apical processes of the pyramidal neuron. He looked at dendritic length and diameter (Sholl, p. 389, Fig. 1) and also the number of cells per volume (Sholl, p. 401, ''The packing density of perikarya''). While methods for estimating the number of cells have vastly improved since 1953 with the advent of unbiased stereology, the method Sholl used to r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polynomial
In mathematics, a polynomial is an expression consisting of indeterminates (also called variables) and coefficients, that involves only the operations of addition, subtraction, multiplication, and positive-integer powers of variables. An example of a polynomial of a single indeterminate is . An example with three indeterminates is . Polynomials appear in many areas of mathematics and science. For example, they are used to form polynomial equations, which encode a wide range of problems, from elementary word problems to complicated scientific problems; they are used to define polynomial functions, which appear in settings ranging from basic chemistry and physics to economics and social science; they are used in calculus and numerical analysis to approximate other functions. In advanced mathematics, polynomials are used to construct polynomial rings and algebraic varieties, which are central concepts in algebra and algebraic geometry. Etymology The word ''polynomial'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear Regression
In statistics, linear regression is a linear approach for modelling the relationship between a scalar response and one or more explanatory variables (also known as dependent and independent variables). The case of one explanatory variable is called '' simple linear regression''; for more than one, the process is called multiple linear regression. This term is distinct from multivariate linear regression, where multiple correlated dependent variables are predicted, rather than a single scalar variable. In linear regression, the relationships are modeled using linear predictor functions whose unknown model parameters are estimated from the data. Such models are called linear models. Most commonly, the conditional mean of the response given the values of the explanatory variables (or predictors) is assumed to be an affine function of those values; less commonly, the conditional median or some other quantile is used. Like all forms of regression analysis, linear regressio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Function (mathematics)
In mathematics, a function from a set to a set assigns to each element of exactly one element of .; the words map, mapping, transformation, correspondence, and operator are often used synonymously. The set is called the domain of the function and the set is called the codomain of the function.Codomain ''Encyclopedia of Mathematics'Codomain. ''Encyclopedia of Mathematics''/ref> The earliest known approach to the notion of function can be traced back to works of Persian mathematicians Al-Biruni and Sharaf al-Din al-Tusi. Functions were originally the idealization of how a varying quantity depends on another quantity. For example, the position of a planet is a ''function'' of time. Historically, the concept was elaborated with the infinitesimal calculus at the end of the 17th century, and, until the 19th century, the functions that were considered were differentiable (that is, they had a high degree of regularity). The concept of a function was formalized at the end of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soma (biology)
The soma (pl. ''somata'' or ''somas''), perikaryon (pl. ''perikarya''), neurocyton, or cell body is the bulbous, non-process portion of a neuron or other brain cell type, containing the cell nucleus. The word 'soma' comes from the Greek '' σῶμα'', meaning 'body'. Although it is often used to refer to neurons, it can also refer to other cell types as well, including astrocytes, oligodendrocytes, and microglia. There are many different specialized types of neurons, and their sizes vary from as small as about 5 micrometres to over 10 millimetres for some of the smallest and largest neurons of invertebrates, respectively. The soma of a neuron (i.e., the main part of the neuron in which the dendrites branch off of) contains many organelles, including granules called Nissl granules, which are composed largely of rough endoplasmic reticulum and free polyribosomes. The cell nucleus is a key feature of the soma. The nucleus is the source of most of the RNA that is produced in neu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analysis
Analysis ( : analyses) is the process of breaking a complex topic or substance into smaller parts in order to gain a better understanding of it. The technique has been applied in the study of mathematics and logic since before Aristotle (384–322 B.C.), though ''analysis'' as a formal concept is a relatively recent development. The word comes from the Ancient Greek ἀνάλυσις (''analysis'', "a breaking-up" or "an untying;" from ''ana-'' "up, throughout" and ''lysis'' "a loosening"). From it also comes the word's plural, ''analyses''. As a formal concept, the method has variously been ascribed to Alhazen, René Descartes ('' Discourse on the Method''), and Galileo Galilei. It has also been ascribed to Isaac Newton, in the form of a practical method of physical discovery (which he did not name). The converse of analysis is synthesis: putting the pieces back together again in new or different whole. Applications Science The field of chemistry uses analysis in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radius
In classical geometry, a radius ( : radii) of a circle or sphere is any of the line segments from its center to its perimeter, and in more modern usage, it is also their length. The name comes from the latin ''radius'', meaning ray but also the spoke of a chariot wheel. as a function of axial position ../nowiki>" Spherical coordinates In a spherical coordinate system, the radius describes the distance of a point from a fixed origin. Its position if further defined by the polar angle measured between the radial direction and a fixed zenith direction, and the azimuth angle, the angle between the orthogonal projection of the radial direction on a reference plane that passes through the origin and is orthogonal to the zenith, and a fixed reference direction in that plane. See also *Bend radius *Filling radius in Riemannian geometry *Radius of convergence * Radius of convexity *Radius of curvature *Radius of gyration ''Radius of gyration'' or gyradius of a body about the axis of r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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