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Shape Theory Of Olfaction
The docking theory of olfaction proposes that the smell of an odorant molecule is due to a range of weak non-covalent interactions between the odorant ligandand one or more G protein-coupled odorant receptors (found in the nasal epithelium). These include intermolecular forces, such as dipole-dipole and Van der Waals interactions, as well as hydrogen bonding. More specific proposed interactions include metal-ion, ion-ion, cation-pi and pi-stacking. Interactions can be influenced by the hydrophobic effect. Conformational changes can also have a significant impact on interactions with receptors, as ligands have been shown to interact with ligands without being in their conformation of lowest energy. While this theory of odorant recognition has previously been described as the shape theory of olfaction, which primarily considers molecular shape and size, this earlier model is oversimplified, since two odorants may have similar shapes and sizes but are subject to different interm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Docking Theory Of Olfaction
The docking theory of olfaction proposes that the smell of an odorant molecule is due to a range of weak non-covalent interactions between the odorant ligandand one or more G protein-coupled odorant receptors (found in the nasal epithelium). These include intermolecular forces, such as dipole-dipole and Van der Waals interactions, as well as hydrogen bonding. More specific proposed interactions include metal-ion, ion-ion, cation-pi and pi-stacking. Interactions can be influenced by the hydrophobic effect. Conformational changes can also have a significant impact on interactions with receptors, as ligands have been shown to interact with ligands without being in their conformation of lowest energy. While this theory of odorant recognition has previously been described as the shape theory of olfaction, which primarily considers molecular shape and size, this earlier model is oversimplified, since two odorants may have similar shapes and sizes but are subject to different inter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linus Pauling
Linus Carl Pauling (; February 28, 1901August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger and Karl Barry Sharpless). Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie. Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Musk
Musk (Persian: مشک, ''Mushk'') is a class of aromatic substances commonly used as base notes in perfumery. They include glandular secretions from animals such as the musk deer, numerous plants emitting similar fragrances, and artificial substances with similar odors. ''Musk'' was a name originally given to a substance with a strong odor obtained from a gland of the musk deer. The substance has been used as a popular perfume fixative since ancient times and is one of the most expensive animal products in the world. The name originates from the Late Greek μόσχος 'moskhos', from Persian 'mushk', similar to Sanskrit मुष्क muṣka ("testicle"), derived from Proto-Indo-European noun ''múh₂s'' meaning "mouse". The deer gland was thought to resemble a scrotum. It is applied to various plants and animals of similar smell (e.g. muskox) and has come to encompass a wide variety of aromatic substances with similar odors, despite their often differing chemical structure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Odorant Receptor
Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants (for example, compounds that have an odor) which give rise to the sense of smell. Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. These receptors are members of the rhodopsin-like receptors, class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of around 800 genes in humans and 1400 genes in mice. Expression In vertebrates, the olfactory receptors are located in both the cilia and synapses of the olfactory sensory neurons and in the epithelium of the human airway. In insects, insect olfactory receptor, olfactory receptors are located on the antenna (biology), antennae and other chemosensory organs. Sperm cells also express odor receptors, which are thought t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Neuroscience
''Nature Neuroscience'' is a monthly scientific journal published by Nature Publishing Group. Its focus is original research papers relating specifically to neuroscience and was established in May 1998. The chief editor is Shari Wiseman. According to the ''Journal Citation Reports'', ''Nature Neuroscience'' had a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 24.884. References External links * Neuroscience journals Nature Research academic journals Publications established in 1998 Monthly journals English-language journals {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leslie B
Leslie may refer to: * Leslie (name), a name and list of people with the given name or surname, including fictional characters Families * Clan Leslie, a Scottish clan with the motto "grip fast" * Leslie (Russian nobility), a Russian noble family of Scottish origin Places Canada * Leslie, Saskatchewan * Leslie Street, a road in Toronto and York Region, Ontario ** Leslie (TTC), a subway station ** Leslie Street Spit, an artificial spit in Toronto United States * Leslie, Arkansas *Leslie, Georgia *Leslie, Michigan *Leslie, Missouri *Leslie, West Virginia * Leslie, Wisconsin *Leslie Township, Michigan *Leslie Township, Minnesota Elsewhere * Leslie Dam, a dam in Warwick, Queensland, Australia * Leslie, Mpumalanga, South Africa * Leslie, Aberdeenshire, Scotland, see List of listed buildings in Leslie, Aberdeenshire * Leslie, Fife, Scotland, UK Other uses * Leslie speaker system * Leslie Motor Car company * Leslie Controls, Inc. * Leslie (singer) (born 1985), French singer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Odotope Theory
Odotope theory, also known as weak shape theory, is a theory of how olfactory receptors bind to odor molecules. The theory proposes that a combination of shape factors determine the coupling. The word itself is an analogy to epitope An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The p ...s. See also * Docking theory of olfaction * Vibration theory of olfaction References * Mori, K. and Shepherd, GM. (1994). Emerging principles of molecular signal processing by mitral/tufted cells in the olfactory bulb. Semin Cell Biol 5-1:65-74. * Burr, Chandler. The Emperor of Scent: A true story of perfume and obsession. Random House, New York: 2002. Olfaction Theories {{receptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G-protein-coupled Receptors
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Text was copied from this source, which is available under Attribution 2.5 Generic (CC BY 2.5) license. Ligands can bind either to extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (Rhodopsin-like family). They are all activated by agonists although a spontaneous auto-activation of an empty receptor can also be observed. G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Axel
Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won him and Linda Buck, a former postdoctoral research scientist in his group, the Nobel Prize in Physiology or Medicine in 2004. Education and early life Born in New York City to Polish Jewish immigrants, Axel grew up in Brooklyn. He graduated from Stuyvesant High School in 1963,(along with Bruce Bueno de Mesquita and Alexander Rosenberg), received his B.A. in 1967 from Columbia University, and his M.D. in 1971 from Johns Hopkins University. He returned to Columbia later that year and eventually became a full professor in 1978. Research and career During the late 1970s, Axel, along with microbiologist Saul J. Silverstein and geneticist Michael H. Wigler, discovered a technique of cotransformation via transfection, a process which allows ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linda Buck
Linda Brown Buck (born January 29, 1947) is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors. She is currently on the faculty of the Fred Hutchinson Cancer Research Center in Seattle. Personal life Linda B. Buck was born in Seattle, Washington on January 29, 1947. Her father was an electrical engineer who spent his time inventing and building different items in his spare time, while her mother was a homemaker who spent a majority of her free time solving word puzzles. Buck was the second of three children, all of them girls. In 1994 Buck met Roger Brent, also a biologist. The two married in 2006. Education Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle. She is the first female University of Washington alumnus to win the Nobel Prize. She was awarded her Ph.D. in immunology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naphthalene
Naphthalene is an organic compound with formula . It is the simplest polycyclic aromatic hydrocarbon, and is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. It is best known as the main ingredient of traditional mothballs. History In the early 1820s, two separate reports described a white solid with a pungent odor derived from the distillation of coal tar. In 1821, John Kidd cited these two disclosures and then described many of this substance's properties and the means of its production. He proposed the name ''naphthaline'', as it had been derived from a kind of naphtha (a broad term encompassing any volatile, flammable liquid hydrocarbon mixture, including coal tar). Naphthalene's chemical formula was determined by Michael Faraday in 1826. The structure of two fused benzene rings was proposed by Emil Erlenmeye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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