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Saccharopolyspora Erythraea
''Saccharopolyspora erythraea'' is a species of actinomycete bacteria within the genus '' Saccharopolyspora''. ''Saccharopolyspora erythraea'' produces the macrolide antibiotic erythromycin. Cytochrome P450 Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various co ... eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B. Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis. References External linksType strain of ''Saccharopolyspora erythraea'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Pseudonocardineae {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Journal Of Systematic Bacteriology
The ''International Journal of Systematic and Evolutionary Microbiology'' is a peer-reviewed scientific journal covering research in the field of microbial systematics that was established in 1951. Its scope covers the taxonomy, nomenclature, identification, characterisation, culture preservation, phylogeny, evolution, and biodiversity of all microorganisms, including prokaryotes, yeasts and yeast-like organisms, protozoa and algae. The journal is currently published monthly by the Microbiology Society. An official publication of the International Committee on Systematics of Prokaryotes (ICSP) and of the International Union of Microbiological Societies (Bacteriology and Applied Microbiology Division), the journal is the single official international forum for the publication of new species names for prokaryotes. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saccharopolyspora
''Saccharopolyspora'' is a genus of bacteria within the family Pseudonocardiaceae. Species ''Saccharopolyspora'' comprises the following species: * '' S. antimicrobica'' Yuan et al. 2008 * '' S. aridisoli'' Saygin et al. 2022 * "'' S. aurantiaca''" Jiang and Xu 1986 * '' S. cavernae'' Cheng et al. 2014 * '' S. cebuensis'' Pimentel-Elardo et al. 2008 * '' S. dendranthemae'' Zhang et al. 2014 * '' S. deserti'' Yang et al. 2018 * '' S. elongata'' Saygin et al. 2022 * '' S. endophytica'' Qin et al. 2021 * '' S. erythraea'' (Waksman 1923) Labeda 1987 * '' S. flava'' Lu et al. 2001 * '' S. gloriosae'' Qin et al. 2010 * '' S. gregorii'' Goodfellow et al. 1989 * "'' S. griseoalba''" Jiang et al. 2016 * '' S. halophila'' Tang et al. 2009 * '' S. halotolerans'' Lv et al. 2014 * '' S. hattusasensis'' Veyisoglu et al. 2018 * '' S. hirsuta'' Lacey and Goodfellow 1975 (Approved Lists 1980) * '' S. hordei'' Goodfellow et al. 1989 * '' S. indica'' Vaddavalli et al. 2014 * '' S. karakumensis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrolide
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but is now used as an immunosuppressant drug and is being investigated as a potential longevity therapeutic. Macrolides are bacteriostatic in that they suppress or inhibit bacterial growth rather than killing bacteria completely. Definition In general, any macrocyclic lactone having greater than 8-membered rings are candidates for this class. The macrocycle may contain amino nitrogen, amide nitrogen (but should be differentiated from cyclopeptides), an oxazole ring, or a thiazole ring. Benzene rings are exclude ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythromycin
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It may also be used during pregnancy to prevent Group B streptococcal infection in the newborn, as well as to improve delayed stomach emptying. It can be given intravenously and by mouth. An eye ointment is routinely recommended after delivery to prevent eye infections in the newborn. Common side effects include abdominal cramps, vomiting, and diarrhea. More serious side effects may include ''Clostridium difficile'' colitis, liver problems, prolonged QT, and allergic reactions. It is generally safe in those who are allergic to penicillin. Erythromycin also appears to be safe to use during pregnancy. While generally regarded as safe during breastfeeding, its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome P450
Cytochromes P450 (CYPs) are a Protein superfamily, superfamily of enzymes containing heme as a cofactor (biochemistry), cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance (pharmacology), clearance of various compounds, as well as for hormone synthesis and breakdown. In 1963, Ronald W. Estabrook, Estabrook, David Y. Cooper, Cooper, and Otto Rosenthal, Rosenthal described the role of CYP as a catalyst in steroid hormone synthesis and drug metabolism. In plants, these proteins are important for the biosynthesis of secondary metabolite, defensive compounds, fatty acids, and hormones. CYP enzymes have been identified in all kingdom (biology), kingdoms of life: animals, plants, fungus, fungi, protists, bacteria, and archaea, as well as in viruses. However, they are not omnipresent; for example, they have not been found in ''Escherichia coli''. , more than 300,000 distinct CYP proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome P450 EryF
6-deoxyerythronolide B hydroxylase is an Actinomycetota Cytochrome P450 enzyme originally from ''Saccharopolyspora erythraea'', catalyzes the 6S-hydroxylate of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) which is the first step of biosynthesis of the macrolide antibiotic erythromycin Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It may also be used duri .... This bacterial enzyme belongs to CYP family CYP107, with the CYP Symbol CYP107A1. References Cytochrome P450 EC 1.14.15 Prokaryote genes {{Enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small RNA
Small RNA (sRNA) are polymeric RNA molecules that are less than 200 nucleotides in length, and are usually non-coding Non-coding DNA (ncDNA) sequences are components of an organism's DNA that do not encode protein sequences. Some non-coding DNA is transcribed into functional non-coding RNA molecules (e.g. transfer RNA, microRNA, piRNA, ribosomal RNA, and regula .... RNA silencing is often a function of these molecules, with the most common and well-studied example being RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the degradation of complementarity (molecular biology), complementary messenger RNA. Other classes of small RNA have been identified, including piwi-interacting RNA (piRNA) and its subspecies rasiRNA, repeat associated small interfering RNA (rasiRNA). Small RNA "is unable to induce RNAi alone, and to accomplish the task it must form the core of the RNA–protein complex termed the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
