SKF-91488

	SKF-91488 SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels. See also Alpha-Fluoromethylhistidine, α-Fluoromethylhistidine Histidine methyl ester References {{Monoamine metabolism modulators Histamine Transferase inhibitors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histamine N-methyltransferase Histamine ''N''-methyltransferase (HNMT, HMT) is an enzyme involved in the metabolism of histamine. It is one of two enzymes involved in the metabolism of histamine in mammals, the other being diamine oxidase (DAO). HNMT catalyzes the methylation of histamine in the presence of ''S''-adenosylmethionine (SAM-e) forming ''N''-methylhistamine. The HNMT enzyme is present in most body tissues but is not present in serum. Histamine ''N''-methyltransferase is encoded by a single gene, ''HNMT'', which in humans has been mapped to chromosome 2. Function The function of the HNMT enzyme is histamine metabolism by ways of ''Nτ''-methylation using SAM-e as the methyl donor, producing ''N''-methylhistamine, which, unless excreted, can be further processed by monoamine oxidase B (MAOB) or by DAO. Methylated histamine metabolites are excreted with urine. In mammals, histamine is metabolized by two major pathways: oxidative deamination via DAO, encoded by the ''AOC1'' gene, and ''Nτ''-methyla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Histamine Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered in 1910, it has been considered a local hormone (autocoid) because it lacks the classic endocrine glands to secrete it; however, in recent years, histamine has been recognized as a central neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histidine Methyl Ester Histidine methyl ester (HME) is an irreversible histidine decarboxylase inhibitor. It is the methyl ester of histidine. See also Histidine decarboxylase The enzyme histidine decarboxylase (, HDC) is transcribed on chromosome 15, region 21.2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmi ... Alpha-Fluoromethylhistidine References Histidine decarboxylase inhibitors Amino acid derivatives Imidazoles Methyl esters Carboxylate esters {{Biochem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histamine Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered in 1910, it has been considered a local hormone (autocoid) because it lacks the classic endocrine glands to secrete it; however, in recent years, histamine has been recognized as a central neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]