|
Rudolph E. Tanzi
Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH). Dr. Tanzi has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that used genetic markers to find a disease gene (Huntington's disease). Dr. Tanzi co-discovered all three familial early-onset Alzheimer's disease (FAD) genes and several other neurological disease genes including that responsible for Wilson’s disease. As the leader of the Cure Alzheimer's Fund Alzheimer's Genome Project, Dr. Tanzi has carried out multiple genome wide association studies of thousands of Alzheimer's families leading to the identification of novel AD candidate genes, including CD33 and the first two rare mutations cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudolph Tanzi
Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH). Dr. Tanzi has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that used genetic markers to find a disease gene (Huntington's disease). Dr. Tanzi co-discovered all three familial early-onset Alzheimer's disease (FAD) genes and several other neurological disease genes including that responsible for Wilson’s disease. As the leader of the Cure Alzheimer's Fund Alzheimer's Genome Project, Dr. Tanzi has carried out multiple genome wide association studies of thousands of Alzheimer's families leading to the identification of novel AD candidate genes, including CD33 and the first two rare mutations cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metlife Foundation Award For Medical Research In Alzheimer's Disease
The Metlife Foundation Award for Medical Research in Alzheimer's Disease were awarded annually from 1986 to 2016 to recognize scientific contributions toward a better understanding of the underlying causes, prevention, and treatments of Alzheimer's disease. The awards were endowed by the Metlife Foundation and administered by The American Federation for Aging Research. Each of the winners received a personal award of US$50,000 and US$200,000 in research funds to further their research. Recipients Source: See also * List of medicine awards * List of neuroscience awards This list of biology awards is an index to articles about notable awards for biology. It includes a general list and lists of ecology, genetics and neuroscience awards. It excludes awards for biochemistry, biomedical science, medicine, ornithol ... References {{DEFAULTSORT:Metlife Foundation Award Medicine awards Neuroscience awards Awards established in 1988 American science and technology awards< ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amylyx Pharmaceuticals
Amylyx Pharmaceuticals, Inc is a biopharmaceutical company headquartered in Cambridge, Massachusetts. Amylyx is best known for AMX0035, an experimental therapy for amyotrophic lateral sclerosis. AMX0035 was approved for medical use in Canada as Albrioza, in June 2022, and in the United States, as Relyvrio, in September 2022. History Amylyx Pharmaceuticals was founded in 2013 by Joshua Cohen and Justin Klee when the two were undergraduate students at Brown University. The two proposed that taurursodiol and sodium phenylbutyrate together might prevent disfunction of mitochondria and the endoplasmic reticulum, safeguarding neurons. Klee and Cohen were advised by Rudolph E. Tanzi, who ultimately served as the founding chair of Amylyx's scientific advisory board. After Klee and Cohen were able to achieve strong results in pre clinical research, Tanzi connected the two to his colleagues at Massachusetts General Hospital, which culminated in clinical trials. The company was granted $ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Moir
Robert David Moir (2 April 1961 – 20 December 2019) was an Australian-born medical research scientist who theorized that the over-accumulation of beta-amyloid, which had formed to protect the brain against microbes, aided the development of Alzheimer's disease in the human brain. Early life He was born in Kojonup in Western Australia to Terrence and Mary Moir who were farmers and had three siblings, Margaret, Andrew and Catherine. He said he only learnt to read and write at age twelve but became an avid reader of all things scientific. Education On completion of high school, he studied biochemistry at the University of Western Australia with one of his microbiology lecturers being Nobel Prize winner Dr Barry Marshall, who discovered that H. pylori cause ulcers. He received his PHD in 1996 from the University of Melbourne, supervised by neuropathologist Dr Colin L. Masters. Career Moir immigrated to the United States in 1994 to work in Dr Rudolph Tanzi's laboratory a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (journal)
''Cell'' is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. The journal was established in 1974 by Benjamin LewinElsevier: ''Cell'': Home (accessed 12 December 2008) and is published twice monthly by , an imprint of |
Beta-amyloid
Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate presentation. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold. A study has suggested that APP and its amyloid potential is of ancient origins, dating as far bac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid Precursor Protein
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many biological tissue, tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene ''APP'' and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose Amyloid#Structure, amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Genetics Amyloid-beta precursor protein is an ancient and highly Conserved sequence, conserved protein. In humans, the gene ''APP'' is located on chromosome 21 and contains 18 exons spanning 290 kilobases. Several alternative splicing isoforms of APP have been observed in humans, ranging in len ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctoral Thesis
A thesis ( : theses), or dissertation (abbreviated diss.), is a document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings.International Standard ISO 7144: DocumentationâPresentation of theses and similar documents International Organization for Standardization, Geneva, 1986. In some contexts, the word "thesis" or a cognate is used for part of a bachelor's or master's course, while "dissertation" is normally applied to a doctorate. This is the typical arrangement in American English. In other contexts, such as within most institutions of the United Kingdom and Republic of Ireland, the reverse is true. The term graduate thesis is sometimes used to refer to both master's theses and doctoral dissertations. The required complexity or quality of research of a thesis or dissertation can vary by country, university, or program, and the required minimum study period may thus vary significantly in du ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Today (American TV Program)
''Today'' (also called ''The Today Show'' or informally, ''NBC News Today'') is an American news and talk morning television show that airs weekdays from 7:00 a.m. to 11:00 a.m. on NBC. The program debuted on January 14, 1952. It was the first of its genre on American television and in the world, and after 70 years of broadcasting it is fifth on the list of longest-running United States television series. Originally a weekday two-hour program from 7:00 a.m. to 9:00 a.m., it expanded to Sundays in 1987 and Saturdays in 1992. The weekday broadcast expanded to three hours in 2000, and to four hours in 2007 (though over time, the third and fourth hours became distinct entities). ''Today''s dominance was virtually unchallenged by the other networks until the late 1980s, when it was overtaken by ABC's ''Good Morning America''. ''Today'' retook the Nielsen ratings lead the week of December 11, 1995, and held onto that position for 852 consecutive weeks until the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deepak Chopra
Deepak Chopra (; ; born October 22, 1946) is an Indian-American author and alternative medicine advocate. A prominent figure in the New Age movement, his books and videos have made him one of the best-known and wealthiest figures in alternative medicine. His discussions of quantum healing have been characterised as technobabble – "incoherent babbling strewn with scientific terms" which drives those who actually understand physics "crazy" and as "redefining Wrong". Chopra studied medicine in India before emigrating in 1970 to the United States, where he completed a residency in internal medicine and a fellowship in endocrinology. As a licensed physician, in 1980 he became chief of staff at the New England Memorial Hospital (NEMH). In 1985, he met Maharishi Mahesh Yogi and became involved in the Transcendental Meditation (TM) movement. Shortly thereafter he resigned his position at NEMH to establish the Maharishi Ayurveda Health Center. In 1993, Chopra gained a following a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
