Robert Lanza
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Robert Lanza
Robert Lanza (born 11 February 1956 in Boston, Massachusetts) is an American medical doctor and scientist, currently Head of Astellas Global Regenerative Medicine, and Chief Scientific Officer of the Astellas Institute for Regenerative Medicine. He is an Adjunct Professor at Wake Forest University School of Medicine. Early life and education Lanza was born in Boston, Massachusetts, and grew up south of there, in Stoughton, Massachusetts. Lanza "altered the genetics of chickens in his basement", and came to the attention of Harvard Medical School researchers when he appeared at the university with his results. Jonas Salk, B. F. Skinner, and Christiaan Barnard mentored Lanza over the next ten years. Lanza attended the University of Pennsylvania, receiving BA and MD degrees. There, he was a Benjamin Franklin Scholar and a University Scholar. Lanza was also a Fulbright Scholar. He currently resides in Clinton, Massachusetts. Career Stem cell research Lanza was part of the te ...
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Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- most populous city in the country. The city boundaries encompass an area of about and a population of 675,647 as of 2020. It is the seat of Suffolk County (although the county government was disbanded on July 1, 1999). The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A broader combined statistical area (CSA), generally corresponding to the commuting area and including Providence, Rhode Island, is home to approximately 8.2 million people, making it the sixth most populous in the United States. Boston is one of the oldest ...
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Harvard Medical School
Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consistently ranked first for research among medical schools by '' U.S. News & World Report''. Unlike most other leading medical schools, HMS does not operate in conjunction with a single hospital but is directly affiliated with several teaching hospitals in the Boston area. Affiliated teaching hospitals and research institutes include Dana–Farber Cancer Institute, Massachusetts General Hospital, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston Children's Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, and Spaulding Rehabilitation Hospital. History Harvard Medical School was founded on September 19, 1782, after President Joseph Willard presented a report w ...
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Kim Kwang-soo
Kim Kwang-soo (born 1954) is a South Korean neuroscientist. Education *B.S. Seoul National University, Department of Microbiology (1977) *M.S. Korea Advanced Institute of Science and Technology (KAIST), Biological Science and Engineering (1979) *Ph.D. Korea Advanced Institute of Science and Technology (KAIST), Biological Science and Engineering ( Dewey D. Ryu) (1983) *M.S.(hon.) Harvard Medical School, Neuroscience (2011) Postdoctoral Training *Postdoc. Fellow, MIT, Dept. of Biology (Molecular Genetics; Lenny Guarente, 1983–1985) *Postdoc. Associate, MIT, Dept. of Biology (Molecular Genetics; Lenny Guarente, 1987–1989) Work Kim is a Professor and Director at the Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School. He has over 20 year experiences to investigate molecular neurobiology of midbrain dopamine neuronal system in health and disease, focusing on elucidating the genetic network of intrinsic signaling molecules and extrinsic transcription f ...
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Hemangioblast
Hemangioblasts are the multipotent precursor cells that can differentiate into both hematopoietic and endothelial cells. In the mouse embryo, the emergence of blood islands in the yolk sac at embryonic day 7 marks the onset of hematopoiesis. From these blood islands, the hematopoietic cells and vasculature are formed shortly after. Hemangioblasts are the progenitors that form the blood islands. To date, the hemangioblast has been identified in human, mouse and zebrafish embryos. Hemangioblasts have been first extracted from embryonic cultures and manipulated by cytokines to differentiate along either hematopoietic or endothelial route. It has been shown that these pre-endothelial/pre-hematopoietic cells in the embryo arise out of a phenotype CD34 population. It was then found that hemangioblasts are also present in the tissue of post-natal individuals, such as in newborn infants and adults. Adult hemangioblast There is now emerging evidence of hemangioblasts that continue to ...
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Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature'' cover the full r ...
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San Diego Zoo
The San Diego Zoo is a zoo in Balboa Park, San Diego, California, housing 4000 animals of more than 650 species and subspecies on of Balboa Park leased from the City of San Diego. Its parent organization, San Diego Zoo Wildlife Alliance, is a private nonprofit conservation organization, and has one of the largest zoological membership associations in the world, with more than 250,000 member households and 130,000 child memberships, representing more than a half million people. The San Diego Zoo was a pioneer in the concept of open-air, cageless exhibits that recreate natural animal habitats. For decades, the zoo housed and successfully bred giant pandas, with the largest giant panda population outside China, before the pandas were repatriated to China in 2019. With more than 4 million visitors in 2018, San Diego Zoo is the most visited zoo in the United States. Travelers have also cited it as one of the best zoos in the world. The San Diego Zoo is an accredited member of the As ...
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Banteng
The banteng (''Bos javanicus''; ), also known as tembadau, is a species of cattle found in Southeast Asia. The head-and-body length is between . Wild banteng are typically larger and heavier than their domesticated counterparts, but are otherwise similar in appearance. The banteng shows extensive sexual dimorphism; adult bulls are generally dark brown to black, larger and more sturdily built than adult cows, which are thinner and usually pale brown or chestnut red. There is a big white patch on the rump. Horns are present on both sexes, and are typically long. Three subspecies are generally recognised. Banteng are active during the day as well as at night, though activity at night is more in areas frequented by humans. Herds comprise two to forty individuals, and generally a single bull. Herbivores, banteng feed on vegetation such as grasses, sedges, shoots, leaves, flowers and fruits. Banteng can survive without water for long stretches during droughts, but drink regularly ...
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Gaur
The gaur (''Bos gaurus''; ), also known as the Indian bison, is a bovine native to South Asia and Southeast Asia, and has been listed as Vulnerable on the IUCN Red List since 1986. The global population was estimated at a maximum of 21,000 mature individuals in 2016, with the majority of those existing in India. It has declined by more than 70% during the last three generations, and is extirpated from Sri Lanka and most likely Bangladesh. Populations in well-protected areas are stable and increasing. It is the largest species among the wild cattle and the Bovidae. The domesticated form of the gaur is called ''gayal'' (''Bos frontalis'') or ''mithun''. Taxonomy ''Bison gaurus'' was the scientific name proposed by Charles Hamilton Smith in 1827. Later authors subordinated the species under either ''Bos'' or ''Bibos''. To date, three gaur subspecies have been recognized: * ''B. g. gaurus'' ranges in India, Nepal and Bhutan; * ''B. g. readei'' described by Richard Lydekke ...
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Embryonic Stem Cell
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre- implantation embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development. Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. Potential uses include the treatment of diabetes and heart disease. The cells are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair. However, adverse effects in the research and clinical processes such as tumors and unwanted ...
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Preimplantation Genetic Diagnosis
Preimplantation genetic diagnosis (PGD or PIGD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization. PGD is considered in a similar fashion to prenatal diagnosis. When used to screen for a specific genetic disease, its main advantage is that it avoids selective abortion, as the method makes it highly likely that the baby will be free of the disease under consideration. PGD thus is an adjunct to assisted reproductive technology, and requires in vitro fertilization (IVF) to obtain oocytes or embryos for evaluation. Embryos are generally obtained through blastomere or blastocyst biopsy. The latter technique has proved to be less deleterious for the embryo, therefore it is advisable to perform the biopsy around day 5 or 6 of development. The world's first PGD was performed by Handyside, Kontogianni and Winston at the Hammersmith Hospital in London. Female embryos were selectively transferre ...
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Therapeutic Cloning
In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking an enucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. "Therapeutic cloning" refers to the potential use of SCNT in regenerative medicine; this approach has been championed as an answer to the many issues concerning embryonic stem cells (ESCs) and the destruction of viable embryos for medical use, though questions remain on how homologous the two cell types truly are. Introduction Somatic cell nuclear trans ...
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Scientific American
''Scientific American'', informally abbreviated ''SciAm'' or sometimes ''SA'', is an American popular science magazine. Many famous scientists, including Albert Einstein and Nikola Tesla, have contributed articles to it. In print since 1845, it is the oldest continuously published magazine in the United States. ''Scientific American'' is owned by Springer Nature, which in turn is a subsidiary of Holtzbrinck Publishing Group. History ''Scientific American'' was founded by inventor and publisher Rufus Porter in 1845 as a four-page weekly newspaper. The first issue of the large format newspaper was released August 28, 1845. Throughout its early years, much emphasis was placed on reports of what was going on at the U.S. Patent Office. It also reported on a broad range of inventions including perpetual motion machines, an 1860 device for buoying vessels by Abraham Lincoln, and the universal joint which now can be found in nearly every automobile manufactured. Current issues includ ...
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