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Rhod Gilbert’s Growing Pains
RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD. It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Interactions RhoD has been shown to interact with CNKSR1 Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the ''CNKSR1'' gene. Function This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It ... and DIAPH2. References Further reading * * * * * * * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G Protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their activity is regulated by factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to the larger group of enzymes called GTPases. There are two classes of G proteins. The first function as monomeric small GTPases (small G-proteins), while the second function as heterotrimeric G protein complexes. The latter class of complexes is made up of '' alpha'' (α), ''beta'' (β) and ''gamma'' (γ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex . Heterotrimeric G proteins located within the cell are activ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein domain common to many GTPases. Functions GTPases function as molecular switches or timers in many fundamental cellular processes. Examples of these roles include: * Signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision. * Protein biosynthesis (a.k.a. translation) at the ribosome. * Regulation of cell differentiation, proliferation, division and movement. * Translocation of proteins through membranes. * Transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. GTPases are active when bound to GTP and inactive when bound to GDP. In the generalized recepto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rac Protein
RAC or Rac may refer to: Organizations * Radio Amateurs of Canada * RATCH-Australia Corporation, electricity generator * Refugee Action Collective (Victoria), Melbourne, Australia * Religious Action Center of Reform Judaism, US * Rent-A-Center, US company * Riverside Arts Council, California, USA * Royal African Company, trading slaves and commodities * Royal Automobile Club (other), several motoring organisations ** RAC Limited, a British motorists' services company ** RAC Foundation, a British motoring advocacy group * Ryukyu Air Commuter, an affiliate of Japan Airlines Military * Royal Armoured Corps of the British Army * Romanian Air Corps, the air arm of the Romanian Army in WWI Sport * RAC Arena (Perth) * Retriever Activities Center, multi-purpose arena, Catonsville, Maryland, US * Rutgers Athletic Center, multi-purpose arena, Piscataway, New Jersey, US * Racing Athletic Club Casablanca, Morocco Music * RAC 1, a radio station in Catalonia, Spain * Recording Art ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rho Family Of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions. History Identification of the Rho family of GTPases began in the mid-1980s. The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. Rac1 and Rac2 were identified next, in 1989 followed by Cdc42 in 1990. Eight additional mammalian Rho members were identified from biological screenings until the late 1990s, a turning point in biology where availability of complete genome seq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNKSR1
Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the ''CNKSR1'' gene. Function This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. Interactions CNKSR1 has been shown to interact with RhoD and RASSF1 Ras association domain-containing protein 1 is a protein that in humans is encoded by the ''RASSF1'' gene. Function This gene encodes a protein similar to the RAS effector proteins. The ''RASSF1'' gene has eight isoforms, of which ''RASSF1A'' .... References Further reading * * * * * * * * * * * * External links * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
