Rho GTPases
Rho GTPase may refer to: *Any member of the Rho family of GTPases *The members of the Rho family of GTPases belonging to the '' Rho subclass'' *RHOA Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is ...

Rho Family Of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions. History Identification of the Rho family of GTPases began in the mid-1980s. The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. Rac1 and Rac2 were identified next, in 1989 followed by Cdc42 in 1990. Eight additional mammalian Rho members were identified from biological screenings until the late 1990s, a turning point in biology where availability of complete genome seq ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  

Rho Subclass
Rho (uppercase Ρ, lowercase ρ or ; el, ρο or el, ρω, label=none) is the 17th letter of the Greek alphabet. In the system of Greek numerals it has a value of 100. It is derived from Phoenician letter res . Its uppercase form uses the same glyph, Ρ, as the distinct Latin letter P; the two letters have different Unicode encodings. Uses Greek Rho is classed as a liquid consonant (together with Lambda and sometimes the nasals Mu and Nu), which has important implications for morphology. In both Ancient and Modern Greek, it represents a alveolar trill , alveolar tap , or alveolar approximant . In polytonic orthography, a rho at the beginning of a word is written with a rough breathing, equivalent to ''h'' ( ''rh''), and a double rho within a word is written with a smooth breathing over the first rho and a rough breathing over the second ( ''rrh''). That apparently reflected an aspirated or voiceless pronunciation in Ancient Greek, which led to the various Gree ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]