|
Restricted Growth Association
The Restricted Growth Association (RGA) is a UK charity that supports people with dwarfism (restricted growth). The RGA was formed in 1970 by Charles Pocock, Martin Nelson and other individuals in the UK wanting to provide a support network for people with restricted growth (dwarfism). Initially known as the Association into Research of Restricted Growth, the charity aims to support all individuals and their families affected by skeletal dysplasia leading to short stature. There are many different forms of dwarfism caused by genetic conditions, but the most common form of disproportionate short stature, causing about 70% of cases, is achondroplasia. There are over 200 known genetic conditions that can lead to short stature (dwarfism). 80% of children born with one of these conditions are born to parents with no previous family history of genetic skeletal dysplasia. The RGA aims to provide support from the first diagnosis and right through the life of the individual. The RGA's ai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charitable Organization
A charitable organization or charity is an organization whose primary objectives are philanthropy and social well-being (e.g. educational, Religion, religious or other activities serving the public interest or common good). The legal definition of a charitable organization (and of charity) varies between countries and in some instances regions of the country. The Charity regulators, regulation, the tax treatment, and the way in which charity law affects charitable organizations also vary. Charitable organizations may not use any of their funds to profit individual persons or entities. (However, some charitable organizations have come under scrutiny for spending a disproportionate amount of their income to pay the salaries of their leadership). Financial figures (e.g. tax refund, revenue from fundraising, revenue from sale of goods and services or revenue from investment) are indicators to assess the financial sustainability of a charity, especially to charity evaluators. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dwarfism
Dwarfism is a condition wherein an organism is exceptionally small, and mostly occurs in the animal kingdom. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dwarfism is , although some individuals with dwarfism are slightly taller. ''Disproportionate dwarfism'' is characterized by either short limbs or a short torso. In cases of ''proportionate dwarfism'', both the limbs and torso are unusually small. Intelligence is usually normal, and most have a nearly normal life expectancy. People with dwarfism can usually bear children, though there are additional risks to the mother and child dependent upon the underlying condition. The most common and recognisable form of dwarfism in humans (comprising 70% of cases) is achondroplasia, a genetic disorder whereby the limbs are diminutive. Growth hormone deficiency is responsible for most other cases. Treatment depends on the underlying cause. Those w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skeletal Dysplasia
Osteochondrodysplasia is a general term for a disorder of the development (dysplasia) of bone ("osteo") and cartilage ("chondro"). Osteochondrodysplasias are rare diseases. About 1 in 5,000 babies are born with some type of skeletal dysplasia. Nonetheless, if taken collectively, genetic skeletal dysplasias or osteochondrodysplasias comprise a recognizable group of genetically determined disorders with generalized skeletal affection. Osteochondrodysplasias can result in marked functional limitation and even mortality. Osteochondrodysplasias subtypes can overlap in clinical aspects, therefore plain radiography is absolutely necessary to establish an accurate diagnosis. Magnetic resonance imaging can provide further diagnostic insights and guide treatment strategies especially in cases of spinal involvement. Early diagnosis, and timely management of skeletal dysplasia are important to combat functional deterioration. Types Achondroplasia ''Achondroplasia'' is a type of autosomal d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Achondroplasia
Achondroplasia is a genetic disorder with an autosomal dominant pattern of inheritance whose primary feature is dwarfism. In those with the condition, the arms and legs are short, while the torso is typically of normal length. Those affected have an average adult height of for males and for females. Other features can include an enlarged head and prominent forehead. Complications can include sleep apnea or recurrent ear infections. Achondroplasia includes short-limb skeletal dysplasia with severe combined immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (''FGFR3'') gene that results in its protein being overactive. Achondroplasia results in impaired endochondral bone growth (bone growth within cartilage). The disorder has an autosomal dominant mode of inheritance, meaning only one mutated copy of the gene is required for the condition to occur. About 80% of cases occur in children of parents of average stature and result f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BIG Lottery Fund
The National Lottery Community Fund, legally named the Big Lottery Fund, is a non-departmental public body responsible for distributing funds raised by the National Lottery for "good causes". Since 2004 it has awarded over £9 billion to more than 130,000 projects in the UK. The Community Fund aims to support projects which help communities and people it considers most in need. Over 80 per cent of its funds go to voluntary and community organisations, it also makes grants to statutory bodies, local authorities and social enterprises. The fund makes grants to projects working in health, education and the environment and the charitable sector. It funds projects in line with objectives set by the government but does not fund services which other parts of government have a statutory responsibility to deliver. "Additionality" principle According to its annual report, Big Lottery Fund uses the following definition of "additionality": "Lottery funding is distinct from Governm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypochondroplasia
Hypochondroplasia (HCH) is a developmental disorder caused by an autosomal dominant genetic defect in the fibroblast growth factor receptor 3 gene (''FGFR3'') that results in a disproportionately short stature, micromeliaupdate 2013 and a head that appears large in comparison with the underdeveloped portions of the body. It is classified as short-limbed dwarfism. Signs and symptoms Individuals affected by this disorder appear normal at birth. As the infant grows, however, their arms and legs do not develop properly, and their body becomes thicker and shorter than normal. The following are characteristics consistent with this condition: * Brachydactyly * Short stature * Micromelia * Skeletal dysplasia * Abnormality of femur Cause Hypochondroplasia is transmitted as an autosomal dominant trait affecting the ''FGFR3'' gene on chromosome 4p16.3. There is currently no cure for this condition. Pathophysiology This disorder results from mutations in the proximal tyrosine kinase domain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tom Shakespeare
Sir Thomas William Shakespeare, 3rd Baronet, (born 11 May 1966) is an English sociologist and bioethicist. He has achondroplasia and uses a wheelchair. Early life and education Son of Sir William Geoffrey Shakespeare, 2nd Baronet, and Susan Mary, daughter of A. Douglas Raffel, of Colombo, Sri Lanka, his grandfather, Sir Geoffrey Shakespeare, was made a baronet following long service as a Member of Parliament and in various senior government roles. While still a student, Tom was featured in a television documentary by Lord Snowdon connected to his 1976 report 'Integrating the Disabled' about his restricted growth, along with his father, a prominent medical practitioner, who was also born with achondroplasia. His mother was a nurse of Sri Lankan Burgher descent. Shakespeare was educated at Radley College, Oxfordshire, taking A-levels in English, History, and History of Art; and Pembroke College, Cambridge, where he matriculated in 1984 to read Anglo-Saxon, Norse and Celtic. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Restricted Growth Organisations Around The World
List of dwarfism organizations around the world. Africa Uganda *Little People of Uganda Asia Hong Kong *Little People of Hong Kong 小而同罕有骨骼疾病基金會 Iran * Iranian Short Stature Association کوتاه قامتان بلند همت :انجمن کوچولوهای ایرانی Iraq * Short Stature in Iraq Australia and Oceania Australia *Short Statured People of Australia New Zealand *Little People of New Zealand Europe Austria *Union of Short-Statured People and their Families (BKMF-Osterreich) Bulgaria * Little Bulgarian People Czech Republic *Association of Little People of Czech Republic Denmark *Danish Dwarf Association (DVF) Finland Small Stature Finland(Finnish: Lyhytkasvuiset – Kortväxta ry) France * Association of the Small (APPT) Germany * Federal Association For The Promotion of People of Short Stature (german: Bundesselbsthilfeverband Kleinwüchsiger Menschen) (VKM) *German Association for People of Shor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Footnotes
A note is a string of text placed at the bottom of a page in a book or document or at the end of a chapter, volume, or the whole text. The note can provide an author's comments on the main text or citations of a reference work in support of the text. Footnotes are notes at the foot of the page while endnotes are collected under a separate heading at the end of a chapter, volume, or entire work. Unlike footnotes, endnotes have the advantage of not affecting the layout of the main text, but may cause inconvenience to readers who have to move back and forth between the main text and the endnotes. In some editions of the Bible, notes are placed in a narrow column in the middle of each page between two columns of biblical text. Numbering and symbols In English, a footnote or endnote is normally flagged by a superscripted number immediately following that portion of the text the note references, each such footnote being numbered sequentially. Occasionally, a number between brack ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dwarfism
Dwarfism is a condition wherein an organism is exceptionally small, and mostly occurs in the animal kingdom. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dwarfism is , although some individuals with dwarfism are slightly taller. ''Disproportionate dwarfism'' is characterized by either short limbs or a short torso. In cases of ''proportionate dwarfism'', both the limbs and torso are unusually small. Intelligence is usually normal, and most have a nearly normal life expectancy. People with dwarfism can usually bear children, though there are additional risks to the mother and child dependent upon the underlying condition. The most common and recognisable form of dwarfism in humans (comprising 70% of cases) is achondroplasia, a genetic disorder whereby the limbs are diminutive. Growth hormone deficiency is responsible for most other cases. Treatment depends on the underlying cause. Those w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Charities In The United Kingdom
Health, according to the World Health Organization, is "a state of complete physical, mental and social well-being and not merely the absence of disease and infirmity".World Health Organization. (2006)''Constitution of the World Health Organization''– ''Basic Documents'', Forty-fifth edition, Supplement, October 2006. A variety of definitions have been used for different purposes over time. Health can be promoted by encouraging healthful activities, such as regular physical exercise and adequate sleep, and by reducing or avoiding unhealthful activities or situations, such as smoking or excessive stress. Some factors affecting health are due to individual choices, such as whether to engage in a high-risk behavior, while others are due to structural causes, such as whether the society is arranged in a way that makes it easier or harder for people to get necessary healthcare services. Still, other factors are beyond both individual and group choices, such as genetic disorders. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1970 Establishments In The United Kingdom
Year 197 ( CXCVII) was a common year starting on Saturday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Magius and Rufinus (or, less frequently, year 950 '' Ab urbe condita''). The denomination 197 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * February 19 – Battle of Lugdunum: Emperor Septimius Severus defeats the self-proclaimed emperor Clodius Albinus at Lugdunum (modern Lyon). Albinus commits suicide; legionaries sack the town. * Septimius Severus returns to Rome and has about 30 of Albinus's supporters in the Senate executed. After his victory he declares himself the adopted son of the late Marcus Aurelius. * Septimius Severus forms new naval units, manning all the triremes in Italy with heavily armed troops for war in the East. His soldiers embark ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
