RbcL 5′ UTR RNA Stabilising Element
The rbcL 5′ UTR RNA stabilising element is an RNA element from '' Chlamydomonas reinhardtii'' that is thought to be involved in the stabilisation of the rbcL gene which codes for large subunit of ribulose-1,5-bisphosphate carboxylase. Mutations in this family can lead to a 50-fold acceleration in degradation of the mRNA transcript. References External links * Cis-regulatory RNA elements {{molecular-cell-biology-stub ...
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Cis-regulatory Element
''Cis''-regulatory elements (CREs) or ''Cis''-regulatory modules (CRMs) are regions of non-coding DNA which regulate the transcription of neighboring genes. CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology. CREs are found in the vicinity of the genes that they regulate. CREs typically regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control the expression of many genes ( pleiotropy). The Latin prefix ''cis'' means "on this side", i.e. on the same molecule of DNA as the gene(s) to be transcribed. CRMs are stretches of DNA, usually 100–1000 DNA base pairs in length, where a number of transcription factors can bind and regulate expression of nearby genes and regulate their transcription rates. They are labeled as ''cis'' because they are ...
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