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Ravinder Dhallan
Ravinder (Rav) Dhallan is the chairman and chief executive officer of Ravgen. Early life and education Dhallan earned an M.D. and a Ph.D. in biomedical engineering at Johns Hopkins University, then began a residency in radiation oncology at Massachusetts General Hospital. Later, after deciding to found the startup firm Ravgen, he studied business at the University of Pennsylvania's Wharton School, receiving an MBA in 2007. Career According to a 2007 ''CNN'' profile, after Dhallan had begun his residency and fathered two children, his wife suffered two miscarriages, which caused him to be “struck by how little information was available to women who experienced complications during pregnancy....so he resolved to invent a better prenatal diagnostic exam.” Amniocentesis provides 100% accurate results, but has a one-in-200 risk of causing a miscarriage and cannot be carried out until 15 or 18 weeks into the pregnancy; existing non-invasive prenatal screenings, meanwhile, have low ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ravgen
' Ravgen Inc. is a privately owned biotech company founded by Chairman and C.E.O. Dr. Ravinder Dhallan. Ravgen Inc. is known for its research in the prenatal diagnostic field and its development of non-invasive prenatal diagnosis testing which was published in The Lancet (Lancet. 2007; 369:474-81), the Journal of the American Medical Association (JAMA. 2004;291:1114-1119)., and the New England Journal of Medicine (NEJM. 2012; 366:1743-1745). These publications received worldwide press in The Times, The Washington Post (February 2007), CNN Fortune Small Business (September 2007), and The New York Times (June 2012) Ravgen was founded in 2000 in Columbia, Maryland by Dr. Ravinder Dhallan. Dr. Dhallan received doctorates in medicine and biomedical engineering at The Johns Hopkins University, as well as an MBA from the Wharton School of Business at the University of Pennsylvania. The CEO and founder of the company held residency positions in oncology at Massachusetts General Hospital ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins University
Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consistently ranks among the most prestigious universities in the United States and the world. The university was named for its first benefactor, the American entrepreneur and Quaker philanthropist Johns Hopkins. Hopkins' $7 million bequest to establish the university was the largest Philanthropy, philanthropic gift in U.S. history up to that time. Daniel Coit Gilman, who was inaugurated as :Presidents of Johns Hopkins University, Johns Hopkins's first president on February 22, 1876, led the university to revolutionize higher education in the U.S. by integrating teaching and research. In 1900, Johns Hopkins became a founding member of the American Association of Universities. The university has led all Higher education in the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania
The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universities by numerous organizations and scholars. While the university dates its founding to 1740, it was created by Benjamin Franklin and other Philadelphia citizens in 1749. It is a member of the Ivy League. The university has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Among its highly ranked graduate schools are its law school, whose first professor wrote the first draft of the United States Constitution, its medical school, the first in North America, and Wharton, the first collegiate business school. Penn's endowment is US$20.7 billio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wharton School
The Wharton School of the University of Pennsylvania ( ; also known as Wharton Business School, the Wharton School, Penn Wharton, and Wharton) is the business school of the University of Pennsylvania, a private Ivy League research university in Philadelphia. Generally considered to be one of the most prestigious business schools in the world, the Wharton School is the world's oldest collegiate business school, having been established in 1881 through a donation from Joseph Wharton. The Wharton School awards the Bachelor of Science with a school-specific economics major, with concentrations in over 18 disciplines in Wharton's academic departments. The degree is a general business degree focused on core business skills. At the graduate level, the Master of Business Administration (MBA) program can be pursued standalone or offers dual studies leading to a joint degree from other schools (e.g., law, engineering, government). Similarly, in addition to its tracks in accounting, finance, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miscarriage
Miscarriage, also known in medical terms as a spontaneous abortion and pregnancy loss, is the death of an embryo or fetus before it is able to survive independently. Miscarriage before 6 weeks of gestation is defined by ESHRE as biochemical loss. Once ultrasound or histological evidence shows that a pregnancy has existed, the used term is clinical miscarriage, which can be ''early'' before 12 weeks and ''late'' between 12-21 weeks. Fetal death after 20 weeks of gestation is also known as a stillbirth. The most common symptom of a miscarriage is vaginal bleeding with or without pain. Sadness, anxiety, and guilt may occur afterwards. Tissue and clot-like material may leave the uterus and pass through and out of the vagina. Recurrent miscarriage (also referred to medically as Recurrent Spontaneous Abortion or RSA) may also be considered a form of infertility. Risk factors for miscarriage include being an older parent, previous miscarriage, exposure to tobacco smoke, obesity, dia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amniocentesis
Amniocentesis is a medical procedure used primarily in the prenatal diagnosis of genetic conditions. It has other uses such as in the assessment of infection and fetal lung maturity. Prenatal diagnostic testing, which includes amniocentesis, is necessary to conclusively diagnose the majority of genetic disorders, with amniocentesis being the gold-standard procedure after 15 weeks' gestation. In this procedure, a thin needle is inserted into the abdomen of the pregnant woman. The needle punctures the amnion, which is the membrane that surrounds the developing fetus. The fluid within the amnion is called amniotic fluid, and because this fluid surrounds the developing fetus, it contains fetal cells. The amniotic fluid is sampled and analyzed via methods such as karyotyping and DNA analysis technology for genetic abnormalities. An amniocentesis is typically performed in the second trimester between the 15th and 20th week of gestation. Women who choose to have this test are prima ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 21
Chromosome 21 is one of the 23 pairs of chromosomes in humans. Chromosome 21 is both the smallest human autosome and chromosome, with 48 million base pairs (the building material of DNA) representing about 1.5 percent of the total DNA in cells. Most people have two copies of chromosome 21, while those with three copies of chromosome 21 have Down syndrome, also called "trisomy 21". Researchers working on the Human Genome Project announced in May 2000 that they had determined the sequence of base pairs that make up this chromosome. Chromosome 21 was the second human chromosome to be fully sequenced, after chromosome 22. Genes Number of genes The following are some of the gene count estimates of human chromosome 21. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) take ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
York, Pennsylvania
York ( Pennsylvania Dutch: ''Yarrick''), known as the White Rose City (after the symbol of the House of York), is the county seat of York County, Pennsylvania, United States. It is located in the south-central region of the state. The population within York's city limits was 43,718 at the 2010 census, a 7.0% increase from the 2000 census count of 40,862. When combined with the adjacent boroughs of West York and North York and surrounding Spring Garden, West Manchester, and Springettsbury townships, the population of Greater York was 108,386. York is the 11th largest city in Pennsylvania. History 18th century York, also known as Yorktown in the mid 18th to early 19th centuries, was founded in 1741 by settlers from the Philadelphia region and named for the English city of the same name. By 1777, most of the area residents were of either German or Scots-Irish descent. York was incorporated as a borough on September 24, 1787, and as a city on January 11, 1887. York served ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Silver Spring, Maryland
Silver Spring is a census-designated place (CDP) in southeastern Montgomery County, Maryland, United States, near Washington, D.C. Although officially unincorporated, in practice it is an edge city, with a population of 81,015 at the 2020 census, making it the fifth-most populous place in Maryland after Baltimore, Columbia, Germantown, and Waldorf. Downtown, next to the northern tip of Washington, D.C., is the oldest and most urbanized part of the community, surrounded by several inner suburban residential neighborhoods inside the Capital Beltway. Many mixed-use developments combining retail, residential, and office space have been built since 2004. Silver Spring takes its name from a mica-flecked spring discovered there in 1840 by Francis Preston Blair, who subsequently bought much of the surrounding land. Acorn Park, south of downtown, is believed to be the site of the original spring. Geography As an unincorporated CDP, Silver Spring's boundaries are not consistently de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia, Maryland
Columbia is a census-designated place in Howard County, Maryland. It is one of the principal communities of the Baltimore–Washington metropolitan area. It is a planned community consisting of 10 self-contained villages. Columbia began with the idea that a city could enhance its residents' quality of life. Creator and developer James W. Rouse saw the new community in terms of human values, rather than merely economics and engineering. Opened in 1967, Columbia was intended to not only eliminate the inconveniences of then-current subdivision design, but also eliminate racial, religious and class segregation. Columbia proper consists only of that territory governed by the Columbia Association, but larger areas are included under its name by the U.S. Postal Service and the Census Bureau. These include several other communities which predate Columbia, including Simpsonville, Atholton, and in the case of the census, part of Clarksville. The census-designated place had a popula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cystic Fibrosis
Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. Cystic fibrosis is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy are carriers and otherwise mostly healthy. CFTR is involved in the production of sweat, digestive fluids, and mucus. When the CFTR is not functional, secretions which are usually thin instead become thick. The condition is diagnosed by a sweat test and genetic testing. Screening of infants at bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
