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RCAN3
''RCAN3'' is a gene that in humans encodes the Calcipressin-3 protein. Calcipressin-3 is a protein that in humans is encoded by the ''RCAN3'' gene and is a member of the Calcipressin family of proteins. Expression RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus. Orthologs RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3). Clinical Significance Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans. Summary box N/A See also * RCAN1 * RCAN2 References Further reading * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcipressin
In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct Binding (molecular), binding. They are essential for the survival of T helper cells, T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when Phosphorylation, phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation. In humans, the Calcipressins Protein family, family of proteins is derived from three genes. RCAN1, Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). RCAN2, Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. RCAN3, Calcipressin 3 is also called MCIP3 and DSCR1-like 2. References {{InterPro content, IPR006931 Protein families ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RCAN1
Down syndrome critical region gene 1, also known as DSCR1, is a protein that in humans is encoded by the ''RCAN1'' gene. Gene location and organization DSCR1 in human is located at the centromeric border of the DSCR and encodes an inhibitor of calcineurin/ NFAT (nuclear factor activated T cells) signalling. DSCR1 genomic sequence of total 45 kb contain 7 exons and 6 introns , different cDNA analysis yield first four exons are alternative and code for two isoforms of 197 amino acids, and one isoform code for 171 amino acids which differ in their N terminal . While the rest of the 168 residues are common. There is also alternative promoter region with about 900 bp between exon 3 and 4 suggesting that the fourth isoform might be penetrated from another promoter. Function The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways of genetic transcription, possibly affecting central nervous system development. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PDB 1wey EBI
PDB may refer to: * Chess Problem Database Server (PDB Server) * 1,4-Dichlorobenzene (paradichlorobenzene) * Party of German-speaking Belgians, (German: '), a political party and predecessor of the ProDG * PDB (Palm OS), a container format for record databases in Palm OS, Garnet OS and Access Linux Platform * ''Pee Dee Belemnite'', a standard for stable Carbon-13 and Oxygen-18 isotopes; see * Pluggable database, such as an Oracle Database in a multitenancy environment * Potato dextrose broth, a common microbiological growth media * Pousette-Dart Band * President's Daily Brief or Briefing or Bulletin, a top-secret intelligence document produced each morning for the U.S. President * Program database, a file format for storing debugging information * Promised Day Brigade, an Iraqi Shia organisation * Protein Data Bank * Protein Data Bank (file format) The Protein Data Bank (PDB) file format is a textual file format describing the three-dimensional structures of molecules ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Esophagus
The esophagus (American English) or oesophagus (British English; both ), non-technically known also as the food pipe or gullet, is an organ in vertebrates through which food passes, aided by peristaltic contractions, from the pharynx to the stomach. The esophagus is a fibromuscular tube, about long in adults, that travels behind the trachea and heart, passes through the diaphragm, and empties into the uppermost region of the stomach. During swallowing, the epiglottis tilts backwards to prevent food from going down the larynx and lungs. The word ''oesophagus'' is from Ancient Greek οἰσοφάγος (oisophágos), from οἴσω (oísō), future form of φέρω (phérō, “I carry”) + ἔφαγον (éphagon, “I ate”). The wall of the esophagus from the lumen outwards consists of mucosa, submucosa (connective tissue), layers of muscle fibers between layers of fibrous tissue, and an outer layer of connective tissue. The mucosa is a stratified squamous epithel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
