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RASSF5
Ras association domain-containing protein 5 is a protein that in humans is encoded by the ''RASSF5 or F5'' gene. Function This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. Interactions RASSF5 has been shown to interact with RRAS, RAP2A, MRAS and RASSF1 Ras association domain-containing protein 1 is a protein that in humans is encoded by the ''RASSF1'' gene. Function This gene encodes a protein similar to the RAS effector proteins. The ''RASSF1'' gene has eight isoforms, of which ''RASSF1A'' .... References Further reading < ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RRAS
Ras-related protein R-Ras is a protein that in humans is encoded by the ''RRAS'' gene. Interactions RRAS has been shown to interact with: * ARAF, * Bcl-2, * NCK1, * RALGDS, and * RASSF5 Ras association domain-containing protein 5 is a protein that in humans is encoded by the ''RASSF5 or F5'' gene. Function This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a va .... References Further reading * * * * * * * * * * * * * * * * * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAP2A
Ras-related protein Rap-2a is a protein that in humans is encoded by the ''RAP2A'' gene. RAP2A is a member of the Ras-related protein family. Interactions RAP2A has been shown to interact with RUNDC3A, RASSF5 and RALGDS Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the ''RALGDS'' gene in humans. Interactions RALGDS has been shown to interact with: * Arrestin beta 1, * Arrestin beta 2, * HRAS, * KRAS, * MRAS, * RAP1A, * RA .... References Further reading * * * * * * * * * * * * * * * * * {{gene-13-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRAS
Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the ''MRAS'' gene on chromosome 3. It is ubiquitously expressed in many tissues and cell types. This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth. The ''MRAS'' gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. Structure Gene The ''MRAS'' gene resides on chromosome 3 at the band 3q22.3 and includes 10 exons. This gene produces 2 isoforms through alternative splicing. Protein M-Ras is a member of the small GTPase superfamily under the Ras family, which also includes Rap1, Rap2, R-Ras, and R-Ras2 (TC21). This protein spans a length of 209 residues. Its N-terminal amino acid sequence shares 60-75% identity with that in the Ras protein while its effector region is identical with that in Ras. M-Ras sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
