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RAB18
Ras-related protein Rab-18 is a protein that in humans is encoded by the ''RAB18'' gene. It is a member of the Rab (G-protein), Rab family of Ras superfamily, Ras-related small GTPases. Rab18 is a ubiquitously expressed protein with particularly high expression in the brain. Rab18 was first characterised as an endosomal protein in epithelium, epithelial cells of mouse kidney and intestines. Subsequent studies revealed that Rab18 has a wide intracellular distribution; localising to the Golgi complex, endoplasmic reticulum, lipid droplets, and cytosol of various cell types. In the brain, Rab18 has been isolated in association with synaptic vesicles and has been observed to localise to secretory granules in neuroendocrine cells. Mutations in ''RAB18'', ''RAB3GAP1'', ''RAB3GAP2'', or ''TBC1D20'' are thought to cause Warburg Micro syndrome by disrupting RAB18 function. ''RAB3GAP1'', ''RAB3GAP2'', and ''TBC1D20'' genes offer instructions for creating proteins that regulate RAB18. The R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rab (G-protein)
The Rab family of proteins is a member of the Ras superfamily of small G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a certain type of protein molecules on the surface. Function Rab proteins are peripheral membrane proteins, anchored to a membrane via a lipid group covalently linked to an amino acid. Specifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
