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RAB11B
Ras-related protein Rab-11B is a protein that in humans is encoded by the ''RAB11B'' gene. Rab11b is reported as most abundantly Gene expression, expressed in brain, heart and testes. Rab (G-protein), Rab (Ras-related in brain) proteins form the largest section of the Ras superfamily of small GTPases. The Rab family proteins regulate intracellular membrane trafficking processes including Vesicle (biology and chemistry), vesicle budding, tethering, and fusion. The isoforms RAB11A, Rab11a, Rab11b, and Rab11c/RAB25, Rab25 constitute the Rab11 subfamily based on specific sequence motifs. While RAB11A is located on Chromosome 15 (human), chromosome 15 and RAB11C on Chromosome 1 (human), chromosome 1, RAB11B is placed on Chromosome 19 (human), chromosome 19. Rab11 proteins are implicated in endocytosis and exocytosis. Rab11b is reported as most abundantly expressed in brain, heart and testes. Early studies with deletions of RAB11 homologs in ''Saccharomyces cerevisiae'' proved their impo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ras Superfamily
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ras, Rho, Ran, Rab and Arf GTPases. The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rap, Rheb, Rad and Rit. ''Miro'' is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity. The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as WASP. In general, the Ras family is responsible for cell proliferation: Rho for cell morphology, Ran for nuclear transport, and Rab and Arf for vesicle transport. Subfamilies and members The following is a list of human proteins belongi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
