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Research Triangle Institute
Research Triangle Institute, trading as RTI International, is a nonprofit organization headquartered in the Research Triangle Park in North Carolina. RTI provides research and technical services. It was founded in 1958 with $500,000 in funding from local businesses and the three North Carolina universities that form the Research Triangle. RTI research has covered topics like HIV/AIDS, healthcare, education curriculum and the environment, among others. The US Agency for International Development accounts for about 35 percent of RTI's research revenue. History In 1954 a building contractor, met with the North Carolina state treasurer and the president of Wachovia to discuss building a research park in North Carolina to attract new industries to the region. They obtained support for the concept from state governor Luther Hodges and the three universities that form the research triangle: University of North Carolina at Chapel Hill, Duke University and North Carolina State Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Triangle Park, North Carolina
Research Triangle Park (RTP) is the largest research park in the United States, occupying in North Carolina and hosting more than 300 companies and 65,000 workers. The facility is named for its location relative to the three surrounding cities of Raleigh, Durham, and Chapel Hill, or more properly, for the three major research universities in them: North Carolina State University, Duke University and University of North Carolina at Chapel Hill respectively. The Research Triangle region of North Carolina received its name as an extension of the name of the park. Aside from the three anchor cities, the park is also bounded by the communities of Morrisville and Cary. Approximately one fourth of the Park's territory lies in Wake County, but the majority of its land is in Durham County. Overview Research Triangle Park is one of the most prominent high-tech research and development parks in the United States. It was created in 1959 by state and local governments, nearby univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Department Of Defense
The United States Department of Defense (DoD, USDOD or DOD) is an executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national security and the United States Armed Forces. The DoD is the largest employer in the world, with over 1.34 million active-duty service members (soldiers, marines, sailors, airmen, and guardians) as of June 2022. The DoD also maintains over 778,000 National Guard and reservists, and over 747,000 civilians bringing the total to over 2.87 million employees. Headquartered at the Pentagon in Arlington, Virginia, just outside Washington, D.C., the DoD's stated mission is to provide "the military forces needed to deter war and ensure our nation's security". The Department of Defense is headed by the secretary of defense, a cabinet-level head who reports directly to the president of the United States. Beneath the Department of Defense are t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
US Department Of Energy
The United States Department of Energy (DOE) is an executive department of the U.S. federal government that oversees U.S. national energy policy and manages the research and development of nuclear power and nuclear weapons in the United States. The DOE oversees the U.S. nuclear weapons program, nuclear reactor production for the United States Navy, energy-related research, and domestic energy production and energy conservation. The DOE was created in 1977 in the aftermath of the 1973 oil crisis. It sponsors more physical science research than any other U.S. federal agency, the majority of which is conducted through its system of National Laboratories. The DOE also directs research in genomics, with the Human Genome Project originating from a DOE initiative. The department is headed by the Secretary of Energy, who reports directly to the president of the United States and is a member of the Cabinet. The current Secretary of Energy is Jennifer Granholm, who has served in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Love Canal
Love Canal is a neighborhood in Niagara Falls, New York, United States, infamous as the location of a landfill that became the site of an enormous environmental disaster in the 1970s. Decades of dumping toxic chemicals harmed the health of hundreds of residents; the area was cleaned up over the course of 21 years in a Superfund operation. In 1890, Love Canal was created as a model planned community, but was only partially developed. In the 1920s, the canal became a dump site for municipal refuse for the city of Niagara Falls. During the 1940s, the canal was purchased by Hooker Chemical Company, which used the site to dump of chemical byproducts from the manufacturing of dyes, perfumes, and solvents for rubber and synthetic resins. Love Canal was sold to the local school district in 1953, after the threat of eminent domain. Over the next three decades, it attracted national attention for the public health problems originating from the former dumping of toxic waste on the gr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government The federal government of the United States (U.S. federal government or U.S. government) is the national government of the United States, a federal republic located primarily in North America, composed of 50 states, a city within a fede ... responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research fundin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding eac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxol
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation. Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division. Paclitaxel was first isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptotheca
''Camptotheca'' (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to tall, native to southern China and Tibet. The genus is usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. The name "happy tree" is a direct translation of the Chinese name xǐ shù ( Simplified Chinese:喜树). There are two species: *''Camptotheca acuminata'' Decne. *'' Camptotheca lowreyana'' S.Y.Li The bark and stems of ''C. acuminata'' contain the alkaloid camptothecin. Several chemical derivatives of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the for ..., rubitecan. ''C. ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of '' Camptotheca acuminata'' (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the treatment of gastrointestinal tumors. CPT showed anticancer activity in preliminary clinical trials, especially against breast, ovarian, colon, lung, and stomach cancers. However, it has low solubility and adverse effects have been reported when used therapeutically, so synthetic and medicinal chemists have developed numerous syntheses of camptothecin and various derivatives to increase the benefits of the chemical, with good results. Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mansukh C
Mansukh () Mansukh is an Indian masculine given name derived from a Sanskrit word meaning "happy heart". Notable people of this name include: * Mansukh Bhuva, Indian politician * Mansukh L. Mandaviya (b. 1972), Indian politician *Mansukh C. Wani Mansukh C. Wani, (died 2020), was a principal scientist (emeritus) at the Research Triangle Institute in North Carolina. He was co-discoverer of Taxol and camptothecin, two anti-cancer drugs considered standard in the treatment to fight ovarian, ... (d. 2020), Indian academic and organic chemist * Bhai Mansukh, Sikh, disciple of Guru Nanak References {{given name, type=both Indian masculine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monroe Wall
Monroe Eliot Wall (1916 – July 6, 2002) was an American chemist, who co-discovered, with Mansukh C. Wani, paclitaxel and camptothecin, two anti-cancer drugs considered standard in the treatment to fight ovarian, breast, lung and colon cancers. On May 27, 1987 Wall received an honorary doctorate from the Faculty of Pharmacy at Uppsala University, Sweden. Wall was born in Newark, New Jersey, in 1916. He completed his BS, MS, and PhD at Rutgers University. He joined the United States Department of Agriculture The United States Department of Agriculture (USDA) is the federal executive department responsible for developing and executing federal laws related to farming, forestry, rural economic development, and food. It aims to meet the needs of com ... (USDA) in 1941 and worked at the USDA until 1960. That year, he started a research group at RTI International, where he remained for the duration of his career. References External linksMonroe E. Wall, National Cance ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RTI Scientists
RTI or Rti may refer to: Broadcasters * Radiodiffusion Television Ivoirienne, state broadcaster of Ivory Coast * Radio Taiwan International, a radio station in Taiwan * Reti Televisive Italiane, an Italian broadcaster and subsidiary of Mediaset Other businesses * RTI International, formerly Research Triangle Institute, a not-for-profit American research organization * RTI International Metals, an American company producing titanium * RTI Producciones, a Colombian television production company In science and technology In computing and telecommunications * Run-time infrastructure (simulation) In medicine * Reproductive tract infection * Respiratory tract infection * Reverse-transcriptase inhibitor, a class of antiretroviral drug Other uses in science and technology * Ramp travel index, a measure of an off road vehicle articulation, ability to keep all wheels in contact with the ground over uneven terrain * Rayleigh–Taylor instability, an instability of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
