Rena D'Souza
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Rena D'Souza
Rena D'Souza (born January 22, 1955) is a clinician-scientist and the Director of the National Institute of Dental and Craniofacial Research. She was formerly the assistant vice president for academic affairs and education for health sciences at the University of Utah where she was also a Professor of Dentistry in the School of Dentistry and a Professor of Neurobiology and Anatomy in the School of Medicine. Early life and education D'Souza was born and raised in Mumbai, India. She attended the University of Mumbai (then the University of Bombay), where she received her Bachelor of Dental Science degree in 1977. She then moved to Houston in the United States where she attended the University of Texas Health Science Center at Houston. There, she received her Doctor of Dental Medicine degree in 1985 and her doctorate degree in 1987. Career D'Souza's research interests center of tissue engineering and dental care, working with tooth stem cells to develop a method to re-grow the ...
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Bombay, India
Mumbai (, ; also known as Bombay — List of renamed Indian cities and states#Maharashtra, the official name until 1995) is the capital city of the Indian States and union territories of India, state of Maharashtra and the ''de facto'' financial centre of India. According to the United Nations, as of 2018, Mumbai is the List of cities in India by population, second-most populous city in India after Delhi and the List of largest cities, eighth-most populous city in the world with a population of roughly 20 million (2 crore). As per the Indian government population census of 2011, Mumbai was the list of cities in India by population, most populous city in India with an estimated city proper population of 12.5 million (1.25 crore) living under the Municipal Corporation of Greater Mumbai, Brihanmumbai Municipal Corporation. Mumbai is the centre of the Mumbai Metropolitan Region, the sixth most populous metropolitan area in the world with a population of over 23 million ...
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Doctor Of Dental Medicine
Doctor or The Doctor may refer to: Personal titles * Doctor (title), the holder of an accredited academic degree * A medical practitioner, including: ** Physician ** Surgeon ** Dentist ** Veterinary physician ** Optometrist *Other roles ** Doctor of the Church, a title given to those with great contribution to Christian theology or doctrine ** Doctor of Philosophy ** Doctor of Pharmacy ** Doctor of Nursing Practice People * The Doctor (nickname), people with nickname or stage name of "Doctor" or "The Doctor" * Sean Doctor (born 1966), American football player * Doctor Willard Bliss (1825–1889), American physician * Doctor Greenwood (1860–1951), English footballer * List of physicians Arts, entertainment, and media Characters * Doctor, a character in 1998 American comedy movie ''My Giant'' * Doctor (''Black Cat'') * Doctor (''Hellsing'') * The Doctor (''Cave Story''), also known as Fuyuhiko Date * The Doctor (''Doctor Who'') * The Doctor (''Star Trek: Voyager' ...
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Jennifer Webster-Cyriaque
Jennifer Y. Webster-Cyriaque is an American dentist and immunologist specializing in the oral microbiome, salivary gland disease in patients with HIV, and cancer-causing viruses. She became the deputy director of the National Institute of Dental and Craniofacial Research in November 2020. Webster-Cyriaque was a faculty member at UNC Adams School of Dentistry and the UNC School of Medicine for 21 years. Education Webster-Cyriaque completed a B.A. in biology and social science in 1988 and a D.D.S. from University at Buffalo in 1992. She earned a doctorate in microbiology and immunology from the University of North Carolina at Chapel Hill (UNC) in 1998. Her dissertation was titled ''The role of Epstein–Barr virus in hairy leukoplakia and other AIDS associated oral mucosal lesions''. was her doctoral advisor. Career Webster-Cyriaque has been part of the UNC Adams School of Dentistry's and the UNC School of Medicine's faculty for over twenty years. Webster-Cyriaque is one of ...
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Martha Somerman
Martha J. Somerman (*March 13, 1947 in Brooklyn, NY, USA) is an internationally known researcher and educator in Medicine, focusing on defining the key regulators controlling development, maintenance, and regeneration of dental, oral, and craniofacial tissues. She is currently (updated Nov 06, 2019) Chief Lab of Laboratory of Oral Connective Tissue Biology (LOCTB) at NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and Director of the National Institute of Dental and Craniofacial Research (NIDCR), a part of the National Institutes of Health (NIH) located in Bethesda, Maryland, USA. Early life and education Martha J. Somerman was born on March 13, 1947, in Brooklyn, N.Y., U.S.A. Martha Somerman gained a Bachelor of Arts (BA) from New York University, Master of Science (MS) from Hunter College, Doctor of Dental Surgery (DDS) from New York University, and a PhD from the University of Rochester. Research and Career Her career at the Universi ...
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International Association For Dental Research
The International Association for Dental Research (IADR) is a professional association, founded in 1920 by William Gies, that focuses on research in the field of dentistry. The aim of this association by constitution is to promote research in all fields of oral and related sciences, to encourage improvements in methods for the prevention and treatment of oral and dental disease, to improve the oral health of the public through research, and to facilitate cooperation among investigators and the communication of research findings and their implications throughout the world. The ''Journal of Dental Research'' (JDR) is the official medical journal of the IADR and the American Association for Dental Research American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, pe .... See also * Prague Section of ...
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PAX9
Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the ''PAX9'' gene. It is also found in other mammals. Expression and function This gene is a member of the paired box (PAX) family of transcription factors. During mouse embryogenesis Pax9 expression starts from embryonic day 8.5 and becomes more evident by E9.5; at this stage its expression is restricted to the pharyngeal endoderm. Later on, Pax9 is also expressed in the axial skeleton. Pax9 is required for craniofacial, tooth and limb development, and may more generally involve development of stratified squamous epithelia as well as various organs and skeletal elements. PAX9 plays a role in the absence of wisdom teeth in some human populations (possibly along with the less well studied AXIN2 and MSX1). Clinical significance This gene was found amplified in lung cancer. The amplification covers three tissue developmental genes - TTF1, NKX2-8, and PAX9. It appears that certain lung cancer ...
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Cleft Palate
A cleft lip contains an opening in the upper lip that may extend into the nose. The opening may be on one side, both sides, or in the middle. A cleft palate occurs when the palate (the roof of the mouth) contains an opening into the nose. The term orofacial cleft refers to either condition or to both occurring together. These disorders can result in feeding problems, speech problems, hearing problems, and frequent ear infections. Less than half the time the condition is associated with other disorders. Cleft lip and palate are the result of tissues of the face not joining properly during development. As such, they are a type of birth defect. The cause is unknown in most cases. Risk factors include smoking during pregnancy, diabetes, obesity, an older mother, and certain medications (such as some used to treat seizures). Cleft lip and cleft palate can often be diagnosed during pregnancy with an ultrasound exam. A cleft lip or palate can be successfully treated with surgery. ...
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Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ...
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Hydrogel
A hydrogel is a crosslinked hydrophilic polymer that does not dissolve in water. They are highly absorbent yet maintain well defined structures. These properties underpin several applications, especially in the biomedical area. Many hydrogels are synthetic, but some are derived from nature. The term 'hydrogel' was coined in 1894. Chemistry Classification The crosslinks which bond the polymers of a hydrogel fall under two general categories: physical and chemical. Chemical hydrogels have covalent cross-linking bonds, whereas physical hydrogels have non-covalent bonds. Chemical hydrogels result in strong irreversible gels due to the covalent bonding, and they may also possess harmful properties which makes them unfavourable for medical applications. Physical hydrogels on the other hand have high biocompatibility, aren’t toxic, and are also easily reversible, by simply changing an external stimulus such as pH or temperature; thus they are favourable for use in medical applicat ...
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Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ...
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Tooth Pulp
The pulp is the connective tissue, nerves, blood vessels, and odontoblasts that comprise the innermost layer of a tooth. The pulp's activity and signalling processes regulate its behaviour. Anatomy The pulp is the neurovascular bundle central to each tooth, permanent or primary. It is composed of a central pulp chamber, pulp horns, and radicular canals. The large mass of the pulp is contained within the pulp chamber, which is contained in and mimics the overall shape of the crown of the tooth.Illustrated Dental Embryology, Histology, and Anatomy, Bath-Balogh and Fehrenbach, Elsevier, 2011, page 164. Because of the continuous deposition of the dentine, the pulp chamber becomes smaller with the age. This is not uniform throughout the coronal pulp but progresses faster on the floor than on the roof or sidewalls. Radicular pulp canals extend down from the cervical region of the crown to the root apex. They are not always straight but vary in shape, size, and number. They are con ...
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Root Canals
In vascular plants, the roots are the organs of a plant that are modified to provide anchorage for the plant and take in water and nutrients into the plant body, which allows plants to grow taller and faster. They are most often below the surface of the soil, but roots can also be aerial or aerating, that is, growing up above the ground or especially above water. Function The major functions of roots are absorption of water, plant nutrition and anchoring of the plant body to the ground. Anatomy Root morphology is divided into four zones: the root cap, the apical meristem, the elongation zone, and the hair. The root cap of new roots helps the root penetrate the soil. These root caps are sloughed off as the root goes deeper creating a slimy surface that provides lubrication. The apical meristem behind the root cap produces new root cells that elongate. Then, root hairs form that absorb water and mineral nutrients from the soil. The first root in seed producing plants is the r ...
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