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RBL Cells
RBL (Rat Basophilic Leukemia cells) are cancerous basophil cells that are well suited for the study of allergies. Uses RBL cells are used in allergy studies due to the strong response of the cells to IgE and its FcεRI receptor. They are used in place of mast cells due to a higher stability in tissue culture. RBL cells can also be humanized, aiding in the specificity of allergy studies to human patients. Infections Mycoplasma ''Mycoplasma'' is a genus of bacteria that, like the other members of the class ''Mollicutes'', lack a cell wall around their cell membranes. Peptidoglycan (murein) is absent. This characteristic makes them naturally resistant to antibiotics ... bacterial infections greatly affects the cell mediator release for biological assays, therefore regular Mycoplasma tests need to be performed since the bacteria colonizes the cell surface and cannot be visualized through a light microscope. References External linksCellosaurus entry for RBL Rodent cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RBL (Rat Basophilic Leukaemia) Cell Line
RBL may refer to: * RBL Bank, an Indian bank * RBL cells, cells used in the study of allergy * RBL Posse, a hip hop group from San Francisco, California * RB Leipzig, a German football club * Real-time Blackhole List or DNSBL, a list of IP addresses most often used to publish addresses linked to spamming * Reasonable benefit limits, a limit on Australian retirement benefits * Research Bureau Limited, the former name of Research International * Rifled breech loader, a type of artillery * Rogers Broadcasting Limited, a Canadian broadcasting company owned and operated by Rogers Communications * The Royal British Legion, a British charity * Rubber band ligation, an outpatient treatment for internal hemorrhoids * Miraya Bikol (ISO 639 code: rbl), a variety of the Albay Bikol language * Red Bluff Municipal Airport Red Bluff Municipal Airport is two miles south of Red Bluff, located just off Interstate 5 in Tehama County, California. It was previously known as Bidwell Airport. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basophil
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. However, they are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and hay fever. They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, heparin that prevents blood clotting, although there are less than that found in mast cell granules. Mast cells were once thought to be basophils that migrated from blood into their resident tissues (connective tissue), but they are now known to be different types of cells. Basophils were discovered in 1879 by German physician Paul Ehrlich, who one year earlier had found a cell type present in tissues that he termed ''mastzellen'' (now mast cells). Ehrl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FcεRI
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in the allergy disorder and parasites immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. It consists of one alpha (FcεRIα – antibody binding site), one beta (FcεRIβ – which amplifies the downstream signal), and two gamma chains (FcεRIγ – the site where the downstream signal initiates) connected by two disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils and is inducible in eosinophils. Tissue distribution FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells, and basophils. As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. FcεRI is also expressed on antigen-presenting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humanized Mouse
A humanized mouse is a mouse carrying functioning human genes, cells, tissues, and/or organs. Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the ''in vivo'' context for understanding of human-specific physiology and pathologies. A lot of our knowledge about several human biological processes has been obtained from studying animal models like rodents and non-human primates Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma .... In particular, small animals such as mice are advantageous in such studies owing to their smal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycoplasma
''Mycoplasma'' is a genus of bacteria that, like the other members of the class ''Mollicutes'', lack a cell wall around their cell membranes. Peptidoglycan (murein) is absent. This characteristic makes them naturally resistant to antibiotics that target cell wall synthesis (like the beta-lactam antibiotics). They can be parasitic or saprotrophic. Several species are pathogenic in humans, including '' M. pneumoniae'', which is an important cause of "walking" pneumonia and other respiratory disorders, and '' M. genitalium'', which is believed to be involved in pelvic inflammatory diseases. ''Mycoplasma'' species (like the other species of the class ''Mollicutes'') are among the smallest organisms yet discovered, can survive without oxygen, and come in various shapes. For example, ''M. genitalium'' is flask-shaped (about 300 x 600 nm), while ''M. pneumoniae'' is more elongated (about 100 x 1000 nm), many ''Mycoplasma'' species are coccoid. Hundreds of ''Mycoplasma'' species i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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