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QuikClot
QuikClot is a brand of hemostatic wound dressing, that contains an agent that promotes blood clotting. It is primarily used by militaries and law enforcement to treat hemorrhaging from trauma. History Using zeolite as a clotting agent was discovered by Frank Hursey (Z-Medica co-founder) in 1984. Following the September 11 attacks the US armed forces conducted a series of tests comparing different antihemorrhagic technologies, in which QuikClot got the best score. Following these tests, the US armed forces approved its use in Afghanistan and Iraq. Zeolite The original formulation of the first generation product contained the active ingredient zeolite, which promoted blood clotting. The zeolite reaction with blood was exothermic, releasing heat during the clotting process, which could cause second degree burns. Because of this, the product was not available for retail and was only used in emergency scenarios, such as in combat. Newer zeolite formulas come pre-hydrated, whi ...
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QuikClot Combat Gauze
QuikClot is a brand of hemostatic wound dressing, that contains an agent that promotes blood clotting. It is primarily used by militaries and law enforcement to treat hemorrhaging from trauma. History Using zeolite as a clotting agent was discovered by Frank Hursey (Z-Medica co-founder) in 1984. Following the September 11 attacks the US armed forces conducted a series of tests comparing different antihemorrhagic technologies, in which QuikClot got the best score. Following these tests, the US armed forces approved its use in Afghanistan and Iraq. Zeolite The original formulation of the first generation product contained the active ingredient zeolite, which promoted blood clotting. The zeolite reaction with blood was exothermic, releasing heat during the clotting process, which could cause second degree burns. Because of this, the product was not available for retail and was only used in emergency scenarios, such as in combat. Newer zeolite formulas come pre-hydrate ...
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Factor XII
Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme () of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the ''F12'' gene. Structure Human Factor XII is 596 amino acids long and consists of two chains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. It is 80,000 daltons. Its heavy chain contains two fibronectin-type domains (type I and II), two epidermal growth factor-like domains, a kringle domain, and a proline-rich region, and its light chain contains the protease domain. The structure of the FnI-EGF-like tandem domain of coagulation factor XII has been solved by X-ray crystallography. Crystal structures of the FXII light chain has also been determined unbound (β-FXII) and bound (β-FXIIa) to inhibitors. Factor XII (FXII, Hageman factor) is a plasma glycoprotein of approximately 90 kDa molecular weight is part ...
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Zeolite
Zeolites are microporous, crystalline aluminosilicate materials commonly used as commercial adsorbents and catalysts. They mainly consist of silicon, aluminium, oxygen, and have the general formula ・y where is either a metal ion or H+. These positive ions can be exchanged for others in a contacting electrolyte solution. exchanged zeolites are particularly useful as solid acid catalysts. The term ''zeolite'' was originally coined in 1756 by Swedish mineralogist Axel Fredrik Cronstedt, who observed that rapidly heating a material, believed to have been stilbite, produced large amounts of steam from water that had been adsorbed by the material. Based on this, he called the material ''zeolite'', from the Greek , meaning "to boil" and , meaning "stone". Zeolites occur naturally but are also produced industrially on a large scale. , 253 unique zeolite frameworks have been identified, and over 40 naturally occurring zeolite frameworks are known. Every new zeolite structure that is ob ...
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Kaolin
Kaolinite ( ) is a clay mineral, with the chemical composition Al2 Si2 O5( OH)4. It is an important industrial mineral. It is a layered silicate mineral, with one tetrahedral sheet of silica () linked through oxygen atoms to one octahedral sheet of alumina () octahedra. Rocks that are rich in kaolinite are known as kaolin () or china clay. Kaolin is occasionally referred to by the antiquated term lithomarge, from the Ancient Greek ''litho-'' and Latin ''marga'', meaning 'stone of marl'. Presently the name lithomarge can refer to a compacted, massive form of kaolin. The name ''kaolin'' is derived from Gaoling (), a Chinese village near Jingdezhen in southeastern China's Jiangxi Province. The name entered English in 1727 from the French version of the word: , following François Xavier d'Entrecolles's reports on the making of Jingdezhen porcelain. Kaolinite has a low shrink–swell capacity and a low cation-exchange capacity (1–15 meq/100 g). It is a soft, earthy, usu ...
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Kaolinite
Kaolinite ( ) is a clay mineral, with the chemical composition Al2 Si2 O5( OH)4. It is an important industrial mineral. It is a layered silicate mineral, with one tetrahedral sheet of silica () linked through oxygen atoms to one octahedral sheet of alumina () octahedra. Rocks that are rich in kaolinite are known as kaolin () or china clay. Kaolin is occasionally referred to by the antiquated term lithomarge, from the Ancient Greek ''litho-'' and Latin ''marga'', meaning 'stone of marl'. Presently the name lithomarge can refer to a compacted, massive form of kaolin. The name ''kaolin'' is derived from Gaoling (), a Chinese village near Jingdezhen in southeastern China's Jiangxi Province. The name entered English in 1727 from the French version of the word: , following François Xavier d'Entrecolles's reports on the making of Jingdezhen porcelain. Kaolinite has a low shrink–swell capacity and a low cation-exchange capacity (1–15 meq/100 g). It is a soft, earthy, ...
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Antihemorrhagics
An antihemorrhagic (antihæmorrhagic) agent is a substance that promotes hemostasis (stops bleeding). It may also be known as a hemostatic (also spelled haemostatic) agent. Antihemorrhagic agents used in medicine have various mechanisms of action: * Systemic drugs work by inhibiting fibrinolysis or promoting coagulation. * Locally acting hemostatic agents work by causing vasoconstriction or promoting platelet aggregation. Medical uses Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis, better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time. Types Systemic There are several classes of antihemorrhagi ...
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Hemostatic Dressing
An antihemorrhagic (antihæmorrhagic) agent is a substance that promotes hemostasis (stops bleeding). It may also be known as a hemostatic (also spelled haemostatic) agent. Antihemorrhagic agents used in medicine have various mechanisms of action: * Systemic drugs work by inhibiting fibrinolysis or promoting coagulation. * Locally acting hemostatic agents work by causing vasoconstriction or promoting platelet aggregation. Medical uses Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis, better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time. Types Systemic There are several classes of antihemorrhagic drug ...
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Antihemorrhagic
An antihemorrhagic (antihæmorrhagic) agent is a substance that promotes hemostasis (stops bleeding). It may also be known as a hemostatic (also spelled haemostatic) agent. Antihemorrhagic agents used in medicine have various mechanisms of action: * Systemic drugs work by inhibiting fibrinolysis or promoting coagulation. * Locally acting hemostatic agents work by causing vasoconstriction or promoting platelet aggregation. Medical uses Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis, better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time. Types Systemic There are several classes of antihemorrhagic drug ...
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Bead
A bead is a small, decorative object that is formed in a variety of shapes and sizes of a material such as stone, bone, shell, glass, plastic, wood, or pearl and with a small hole for threading or stringing. Beads range in size from under to over in diameter. Beads represent some of the earliest forms of jewellery, with a pair of beads made from ''Nassarius'' sea snail shells dating to approximately 100,000 years ago thought to be the earliest known example. Beadwork is the art or craft of making things with beads. Beads can be woven together with specialized thread, strung onto thread or soft, flexible wire, or adhered to a surface (e.g. fabric, clay). Types of beads Beads can be divided into several types of overlapping categories based on different criteria such as the materials from which they are made, the process used in their manufacturing, the place or period of origin, the patterns on their surface, or their general shape. In some cases, such as millefiori and ...
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United States Department Of Defense
The United States Department of Defense (DoD, USDOD or DOD) is an executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national security and the United States Armed Forces. The DoD is the largest employer in the world, with over 1.34 million active-duty service members (soldiers, marines, sailors, airmen, and guardians) as of June 2022. The DoD also maintains over 778,000 National Guard and reservists, and over 747,000 civilians bringing the total to over 2.87 million employees. Headquartered at the Pentagon in Arlington, Virginia, just outside Washington, D.C., the DoD's stated mission is to provide "the military forces needed to deter war and ensure our nation's security". The Department of Defense is headed by the secretary of defense, a cabinet-level head who reports directly to the president of the United States. Beneath the Department of Defense are th ...
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Tourniquet
A tourniquet is a device that is used to apply pressure to a limb or extremity in order to stop the flow of blood. It may be used in emergencies, in surgery, or in post-operative rehabilitation. A simple tourniquet can be made from a stick and a rope, but the use of makeshift tourniquets has been reduced over time due to their ineffectiveness compared to a commercial and professional tourniquet. This may stem the flow of blood, but side effects such as soft tissue damage and nerve damage may occur. Types There are three types of tourniquets: surgical tourniquets, emergency tourniquets, and rehabilitation tourniquets. Surgical tourniquets Silicone ring tourniquets, or elastic ring tourniquets, are self-contained mechanical devices that do not require any electricity, wires or tubes. The tourniquet comes in a variety of sizes. To determine the correct product size, the patient's limb circumference at the desired occlusion location should be measured, as well as their bloo ...
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Tactical Combat Casualty Care
Tactical Combat Casualty Care (TCCC or TC3) are the United States military guidelines for trauma life support in prehospital combat medicine, designed to reduce preventable deaths while maintaining operation success. The TCCC guidelines are routinely updated and published by the Committee on Tactical Combat Casualty Care (CoTCCC), which is part of the Defense Committees on Trauma (DCoT) division of the Defense Health Agency (DHA). TCCC was designed in the 1990s for the Special Operations Command medical community. Originally a joint Naval Special Warfare Command and Special Operations Medical Research & Development initiative, CoTCCC developed combat-appropriate and evidence-based trauma care based on injury patterns of previous conflicts. The original TCCC corpus was published in a Military Medicine supplement in 1996. TCCC has since become a Department of Defense (DoD) course, conducted by National Association of Emergency Medical Technicians. Committee on Tactical Comba ...
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